Bone morphogenetic protein 10 explained

Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.^[1]

BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins.^[2] It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.

Further reading

• Davila S . New genetic associations detected in a host response study to hepatitis B vaccine . Genes Immun. . 11 . 3 . 232–8 . 2010 . 20237496 . 10.1038/gene.2010.1 . Froeling FE . Tan A . 3 . Bonnard . C . Boland . G J . Snippe . H . Hibberd . M L . Seielstad . M . 11183658 .
• Hillier LW . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . Graves TA . Fulton RS . 3 . Fulton . Lucinda A. . Pepin . Kymberlie H. . Minx . Patrick . Wagner-Mcpherson . Caryn . Layman . Dan . Wylie . Kristine . 2005Natur.434..724H . free .
• Mazerbourg S . Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses . J. Biol. Chem. . 280 . 37 . 32122–32 . 2005 . 16049014 . 10.1074/jbc.M504629200 . Sangkuhl K . Luo CW . 3 . Sudo . S . Klein . C . Hsueh . AJ . free.
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Nakano N . Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy . Am. J. Physiol. Heart Circ. Physiol. . 293 . 6 . H3396–403 . 2007 . 17921333 . 10.1152/ajpheart.00311.2007 . Hori H . Abe M . 3 . Shibata . H. . Arimura . T. . Sasaoka . T. . Sawabe . M. . Chida . K. . Arai . T. . 45084505 .
• Marroni F . A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project . Circ Cardiovasc Genet . 2 . 4 . 322–8 . 2009 . 20031603 . 10.1161/CIRCGENETICS.108.833806 . 2760953 . Pfeufer A . Aulchenko YS . 3 . Franklin . C. S. . Isaacs . A. . Pichler . I. . Wild . S. H. . Oostra . B. A. . Wright . A. F. .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• David L . Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells . Blood . 109 . 5 . 1953–61 . 2007 . 17068149 . 10.1182/blood-2006-07-034124 . Mallet C . Mazerbourg S . 3 . Feige . J.-J. . Bailly . S. . free .

Notes and References

1. Web site: Entrez Gene: bone morphogenetic protein 10.
2. Neuhaus H, Rosen V, Thies RS. Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mech. Dev.. 80. 2. 181–4. February 1999. 10072785. 10.1016/S0925-4773(98)00221-4. 15626081.