Bombesin-like receptor 3 explained

The bombesin receptor subtype 3 also known as BRS-3 or BB₃^[1] is a protein which in humans is encoded by the BRS3 gene.^{[2] [3]}

Function

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).^{[3] [4]}

BB₃ is a G protein-coupled receptor. BB₃ only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.^{[5] [6]}

Further reading

• Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F . Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus . FEBS Lett. . 340 . 3 . 260–4 . 1994 . 8131855 . 10.1016/0014-5793(94)80150-9 . 99786 . free .
• Fathi Z, Corjay MH, Shapira H . BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells . J. Biol. Chem. . 268 . 8 . 5979–84 . 1993 . 10.1016/S0021-9258(18)53415-3 . 8383682 . etal. free .
• Kane MA, Toi-Scott M, Johnson GL . Bombesin-like peptide receptors in human bronchial epithelial cells . Peptides . 17 . 1 . 111–8 . 1996 . 8822519 . 10.1016/0196-9781(95)02088-8 . 30893871 . etal.
• Ohki-Hamazaki H, Watase K, Yamamoto K . Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity . Nature . 390 . 6656 . 165–9 . 1997 . 9367152 . 10.1038/36568 . 1997Natur.390..165O . 4400418 . etal.
• Ryan RR, Weber HC, Hou W . Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3 . J. Biol. Chem. . 273 . 22 . 13613–24 . 1998 . 9593699 . 10.1074/jbc.273.22.13613 . etal. free .
• Liu J, Lao ZJ, Zhang J . Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3) . Biochemistry . 41 . 28 . 8954–60 . 2002 . 12102638 . 10.1021/bi0202777 . etal.
• Ross MT, Grafham DV, Coffey AJ . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R . etal.
• Hou X, Wei L, Harada A, Tatamoto K . Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells . Lung Cancer . 54 . 2 . 143–8 . 2007 . 16979789 . 10.1016/j.lungcan.2006.08.005 .
• Tan YR, Qin XQ, Xiang Y . PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells . Biochem. J. . 405 . 1 . 131–7 . 2007 . 17355223 . 10.1042/BJ20061754 . 1925247 . etal.

External links

• Web site: Bombesin Receptors: BB₃ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2007-10-25 . 2016-03-03 . https://web.archive.org/web/20160303181534/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958 . dead .

Notes and References

1. Web site: Bombesin Receptors: BB₃ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2007-10-25 . 2016-03-03 . https://web.archive.org/web/20160303181534/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958 . dead .
2. Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF . BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells . J. Biol. Chem. . 268 . 8 . 5979–84 . March 1993 . 10.1016/S0021-9258(18)53415-3 . 8383682 . free .
3. Ohki-Hamazaki H, Wada E, Matsui K, Wada K . Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse . Brain Res. . 762 . 1–2 . 165–72 . July 1997 . 9262170 . 10.1016/S0006-8993(97)00380-6. 1012779 .
4. Web site: Entrez Gene: BRS3 bombesin-like receptor 3.
5. Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT . Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors . J. Biol. Chem. . 272 . 41. 26062–26071 . 1997 . 9325344 . 10.1074/jbc.272.41.26062. free .
6. Jensen RT, Battey JF, Spindel ER, Benya RV . International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states . Pharmacol. Rev. . 60 . 1. 1–42 . 2007 . 18055507 . 10.1124/pr.107.07108. 2517428 .