Blood–brain barrier disruption explained

Blood–brain barrier disruption is the surgical process whereby drugs are used to create openings between cells in the blood–brain barrier.^[1]

Purpose

The blood–brain barrier (BBB) is protected by a network of blood vessels and tissue that shields it from harmful substances. This protection also stops anti-cancer drugs from getting to the brain. To treat brain tumours and other brain related diseases,^{[2] [3]} blood–brain barrier disruption is needed for the anti-cancer drugs to be infused into an artery that goes to the brain.

Effects

Studies have shown that blood–brain barrier disruption can cause diseases in the central nervous system.^{[4] [5]}

Notes and References

1. Web site: 2011-02-02. Definition of blood–brain barrier disruption. 2023-02-09. www.cancer.gov. en.
2. Tomkins. O.. Shelef. I.. Kaizerman. I.. Eliushin. A.. Afawi. Z.. Misk. A.. Gidon. M.. Cohen. A.. Zumsteg. D.. Friedman. A.. 2008-07-01. Blood–brain barrier disruption in post-traumatic epilepsy. Journal of Neurology, Neurosurgery & Psychiatry. en. 79. 7. 774–777. 10.1136/jnnp.2007.126425. 0022-3050. 17991703. 29504371 .
3. Web site: Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors . ClinicalTrials.gov . 2024-08-06.
4. Segura-Collar. Berta. Mata-Martínez. Pablo. Hernández-Laín. Aurelio. Sánchez-Gómez. Pilar. Gargini. Ricardo. June 2022. Blood–brain barrier Disruption: A Common Driver of Central Nervous System Diseases. The Neuroscientist . 28. 3. 222–237. 10.1177/1073858420985838. 1089-4098. 33446074. 20.500.12105/11670 . 231611519 . free.
5. Okada. Takeshi. Suzuki. Hidenori. Travis. Zachary D.. Zhang. John H.. The Stroke-Induced Blood–brain barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target. Current Neuropharmacology. 2020 . en. 18. 12. 1187–1212. 10.2174/1570159X18666200528143301 . 32484111 . 7770643 .