Bis(trifluoromethyl) disulfide explained

Bis(trifluoromethyl) disulfide (TFD) is a fluorinated organosulfur compound that was used as a fumigant.^[1] It is also an intermediate in the synthesis of triflic acid. It is a volatile liquid that is extremely toxic by inhalation.

Synthesis

TFD can be produced by reaction of perchloromethyl mercaptan or thiophosgene with sodium fluoride.^[2]

Toxicity

TFD is extremely toxic by inhalation. TFD is a powerful pulmonary agent that can cause severe pulmonary edema.^[3] TFD is about half as toxic as perfluoroisobutene.^[4]

See also

• Dimethyl(trifluoromethylthio)arsine
• Perchloromethyl mercaptan
• Thiophosgene
• Perfluoroisobutene
• Phosgene

Notes and References

1. Web site: Fumigation with bis(trifluoromethyl) disulfide .
2. Web site: Reaction of metal fluorides with thiophosgene and perchloromethyl mercaptan .
3. Web site: Progressive Pulmonary Pathology of Two Organofluorine Compounds in Rats . 1991 . Nold . J. B. . Petrali . J. P. . Wall . H. G. . Moore . D. H. .
4. Book: 10.1016/B978-008043405-6/50040-2. Highly-toxic fluorine compounds. Fluorine Chemistry at the Millennium. 2000. Timperley. Christopher M.. 499–538. 9780080434056.