Bis(5'-nucleosyl)-tetraphosphatase (symmetrical) explained

bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
Ec Number:	3.6.1.41
Cas Number:	85638-48-8
Go Code:	0008803

In enzymology, a bis(5'-nucleosyl)-tetraphosphatase (symmetrical) is an enzyme that catalyzes the chemical reaction

P₁,P₄-bis(5'-adenosyl) tetraphosphate + H₂O

\rightleftharpoons 2 ADP

Thus, the two substrates of this enzyme are P1,P4-bis(5'-adenosyl) tetraphosphate and H₂O, whereas its product is ADP.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase. Other names in common use include diadenosinetetraphosphatase (symmetrical), dinucleosidetetraphosphatasee (symmetrical), symmetrical diadenosine tetraphosphate hydrolase, adenosine tetraphosphate phosphodiesterase, Ap4A hydrolase, bis(5'-adenosyl) tetraphosphatase, diadenosine tetraphosphate hydrolase, diadenosine polyphosphate hydrolase, diadenosine 5',5-P1,P4-tetraphosphatase, diadenosinetetraphosphatase (symmetrical), 1-P,4-P-bis(5'-nucleosyl)-tetraphosphate, and nucleosidebisphosphohydrolase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

• Barnes LD, Culver CA . 1982 . Isolation and characterization of diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase from Physarum polycephalum . Biochemistry . 21 . 6123 - 8 . 6295456 . 10.1021/bi00267a015 . 24 .
• Guranowski A, Jakubowski H, Holler E . 1983 . Catabolism of diadenosine 5',5"'-P1,P4-tetraphosphate in procaryotes. Purification and properties of diadenosine 5',5"'-P1,P4-tetraphosphate (symmetrical) pyrophosphohydrolase from Escherichia coli K12 . J. Biol. Chem. . 258 . 14784 - 9 . 6317672 . 24 . 10.1016/S0021-9258(17)43729-X . free .