Biphasic disease explained

A biphasic disease is a disease which has two distinct phases or components. In clinically biphasic diseases, the phases are generally chronologically separated. In histopathologically biphasic tumors (also called biplastic tumors), there is neoplastic tissue which contains two different cellular elements.[1] [2]

Examples

Clinically biphasic diseases

Disease Typical first phase Typical second phase
European (or "Western") subtype of tick-borne encephalitis virus[3] [4] Affecting some cases, generally presenting with high fever and neurologic disease (encephalitis), meningitis and/or meningoencephalitis)
Leptospirosis[5] Fever, jaundice, abdominal pain and diarrhoea. Organ failure in severe cases.
Anthrax[6] After approximately 4 days, patients develop flu-like illness with fever, nonproductive cough, and myalgias lasting approximately 4 days Without timely treatment, a second fulminant phase follows, characterized by hypotension and dyspnea. This phase may progress to death within 24 hours of its onset.

Tumor biplasia

See main article: Mixed tumor.

Disease Cellular elements
Fibroadenoma[7] Stroma
Ceruminous adenoma[8] Inner luminal secretory cells Myoepithelial cells

Notes and References

  1. Salati SA. Breast fibroadenomas: a review in the light of current literature. . Pol Przegl Chir . 2020 . 93 . 1 . 40–48 . 33729177 . 10.5604/01.3001.0014.5676 . 232262405 .
  2. Babu R S . Arvind . Reddy B V . Ramana . C H . Anuradha . Histogenetic concepts, terminology and categorization of biphasic tumours of the oral and maxillofacial region . Journal of Clinical and Diagnostic Research . February 2014 . 8 . 2 . 266–270 . 10.7860/JCDR/2014/7506.4078 . 24701553 . 3972583 .
  3. Veje . Malin . Studahl . Marie . Johansson . Maja . Johansson . Patrik . Nolskog . Peter . Bergström . Tomas . Diagnosing tick-borne encephalitis: a re-evaluation of notified cases . European Journal of Clinical Microbiology & Infectious Diseases . February 2018 . 37 . 2 . 339–344 . 10.1007/s10096-017-3139-9 . 29188467 . 5780526 . free .
  4. Kaiser . Reinhard . Tick-Borne Encephalitis . Infectious Disease Clinics of North America . September 2008 . 22 . 3 . 561–575 . 10.1016/j.idc.2008.03.013 . 18755391 .
  5. Web site: Factsheet about leptospirosis. European Centre for Disease Prevention and Control. 16 July 2010 . Page last updated 26 Jun 2017
  6. Sweeney . Daniel A. . Hicks . Caitlin W. . Cui . Xizhong . Li . Yan . Eichacker . Peter Q. . Anthrax Infection . American Journal of Respiratory and Critical Care Medicine . 15 December 2011 . 184 . 12 . 1333–1341 . 10.1164/rccm.201102-0209CI . 21852539 . 3361358 .
  7. Book: Tavassoli . F.A. . Devilee . P. . World Health Organization Classification of Tumours: Pathology & Genetics: Tumours of the breast and female genital organs . IARC Press . Lyon . 2003 . 978-92-832-2412-9 .
  8. Ceruminous adenomas: a clinicopathologic study of 41 cases with a review of the literature. Thompson LD, Nelson BL, Barnes EL . Am J Surg Pathol. Mar 2004. 28. 3. 308–18. 15104293. 10.1097/00000478-200403000-00003. 27571673 .

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