Biotin-independent malonate decarboxylase explained

Biotin-independent malonate decarboxylase
Ec Number:	4.1.1.88

Biotin-independent malonate decarboxylase (malonate decarboxylase (without biotin), malonate decarboxylase, MDC) is an enzyme with systematic name malonate carboxy-lyase (biotin-independent).^{[1] [2] [3] [4] [5] [6] [7] [8] [9]} This enzyme catalyses the following chemical reaction

malonate + H⁺

\rightleftharpoons acetate + CO₂

Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes.

Notes and References

1. Schmid M, Berg M, Hilbi H, Dimroth P . Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group . European Journal of Biochemistry . 237 . 1 . 221–8 . April 1996 . 8620876 . 10.1111/j.1432-1033.1996.0221n.x .
2. Subunit organization of bacterial malonate decarboxylases: the smallest δ subunit as an acyl-carrier protein . Byun, H.S. . Kim, Y.S. . J. Biochem. Mol. Biol. . 1997 . 30 . 132–137 .
3. Hoenke S, Schmid M, Dimroth P . Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli . European Journal of Biochemistry . 246 . 2 . 530–8 . June 1997 . 9208947 . 10.1111/j.1432-1033.1997.00530.x . free .
4. Chohnan S, Fujio T, Takaki T, Yonekura M, Nishihara H, Takamura Y . Malonate decarboxylase of Pseudomonas putida is composed of five subunits . FEMS Microbiology Letters . 169 . 1 . 37–43 . December 1998 . 9851033 . 10.1111/j.1574-6968.1998.tb13296.x . free .
5. Hoenke S, Schmid M, Dimroth P . Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases . Biochemistry . 39 . 43 . 13233–40 . October 2000 . 11052676 . 10.1021/bi001154u .
6. Handa S, Koo JH, Kim YS, Floss HG . Stereochemical course of biotin-independent malonate decarboxylase catalysis . Archives of Biochemistry and Biophysics . 370 . 1 . 93–6 . October 1999 . 10496981 . 10.1006/abbi.1999.1369 .
7. Koo JH, Kim YS . Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus . European Journal of Biochemistry . 266 . 2 . 683–90 . December 1999 . 10561613 . 10.1046/j.1432-1327.1999.00924.x . free .
8. Kim YS . Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application . Journal of Biochemistry and Molecular Biology . 35 . 5 . 443–51 . September 2002 . 12359084 . 10.5483/bmbrep.2002.35.5.443 . free .
9. Dimroth P, Hilbi H . Enzymic and genetic basis for bacterial growth on malonate . Molecular Microbiology . 25 . 1 . 3–10 . July 1997 . 11902724 . 10.1046/j.1365-2958.1997.4611824.x . free .