Biomedical Research Center Explained

The Biomedical Research Center (BRC) is a research center at Qatar University focusing on biomedical research. BRC was founded in 2014, and partners with the Ministry of Public Health (Qatar), and Hamad Medical Corporation (HMC).[1] [2] [3]

History

The incidence of genetic disorders in Qatar is high,[4] with the top three causes of death in the country being cancer, heart diseases, and diabetes.[5] [6] The government saw the creation of BRC as a strategy for proactively preventing diseases to help foster public health.[7] [8]

BRC labs received the ISO/IEC - 17025 accreditation from the American Association for Laboratory Accreditation (A2LA).[9] This research center focus on infectious diseases (virology and microbiology), metabolic disorders, and biomedical omics.[10]

Research

Since its establishment in 2014, the BRC has published over 530 research papers.[11] [12] The centre's research projects encompass a range of areas, including:

  1. Antibiotic profiling of antibiotic-resistant microbes in humans and animals.[13] [14] [15] [16] [17]
  2. Investigating variations in cases of type 2 diabetes.[18] [19]
  3. Studying COVID-19,[20] [21] [22] [23] [24] [25] [26] [27] [28] including the Omicron variant.[29] [30] [31]
  4. Conducting genetic sequencing of Qatari falcons, endangered animal species,[32] and the dugong.
  5. Exploring nanomedicine as a means of disease prevention.[33] [34] [35]

Zebrafish Research Model

BRC Introduced the use of zebrafish as an animal model in biomedical research[36] [37] [38] [39] [40] and established a facility for it in 2015.[41] [42] [43] The facility is used as a research unit to study many genetic diseases. The Ministry of Public Health articulated an institutional research policy (IRP) on the use of zebrafish in research,[44] which Qatar University backed.

Facilities

The BRC facilities include:

See also

External links

Notes and References

  1. Web site: 2015-11-05 . BRC AND SCH SIGN COLLABORATIVE AGREEMENT . www.qu.edu.qa.
  2. Web site: 2023 . Biomedical Research Center Qatar University . www.qu.edu.qa.
  3. Web site: 2023 . Qatar puts the pursuit of knowledge front and centre . en.
  4. Web site: 2023 . Research Qatar Genome Programme . www.qatargenome.org.qa.
  5. Web site: 2015-09-09 . Qatar . Institute for Health Metrics and Evaluation . en.
  6. Web site: 2020-10-19 . Health and Biomedical Sciences . Qatar University.
  7. Web site: July 2008 . Qatar National Vision 2030 General Secretariat For Development Planning .
  8. Web site: 2020-10-19 . Research Pillars and Priorities Qatar University . www.qu.edu.qa.
  9. Web site: 2018-07-01 . QU BIOMEDICAL RESEARCH CENTER AND LABORATORY ANIMAL RESEARCH CENTER AWARDED ISO IEC - 17025 ACCREDITATION . www.qu.edu.qa.
  10. Web site: Divisions and Researches Qatar University . 2023-03-14 . www.qu.edu.qa.
  11. Web site: 2022-02-24 . BRC Publications . Qatar University.
  12. Web site: 2023 . Qatar University Institutional Repository Biomedical Research Center . qspace.qu.edu.qa.
  13. 6 . El Zowalaty ME, Al Thani AA, Webster TJ, El Zowalaty AE, Schweizer HP, Nasrallah GK, Marei HE, Ashour HM . 2015-10-01 . Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies . Future Microbiology . 10 . 10 . 1683–1706 . 10.2217/fmb.15.48 . 26439366.
  14. Johar AR, Abu-Rub LI, Al Mana H, Yassine HM, Eltai NO . September 2022 . Microbiome engineering to combat antimicrobial resistance and upsurge productivity of food animals: a systematic review. . Animal Production Science . 63 . 2 . 101–112 . 10.1071/AN22233 . 252257034 . free . 10576/34433.
  15. Eltai NO, Yassine HM, Al Thani AA, Abu Madi MA, Ismail A, Ibrahim E, Alali WQ . 2018 . Prevalence of antibiotic resistant Escherichia coli isolates from fecal samples of food handlers in Qatar . Antimicrobial Resistance and Infection Control . 7 . 78 . 10.1186/s13756-018-0369-2 . 6019201 . 29983931 . free.
  16. Al-Hadidi SH, Al Mana H, Almoghrabi SZ, El-Obeid T, AlAli WQ, Eltai NO . July 2022 . Retail Chicken Carcasses as a Reservoir of Multidrug-Resistant Salmonella . Microbial Drug Resistance . Larchmont, N.Y. . 28 . 7 . 824–831 . 10.1089/mdr.2021.0414 . 9347385 . 35675669.
  17. Web site: 2020-03-29 . Qatar University's Biomedical Research Center conducting research on COVID-19 . 2023-03-14 . The Peninsula Newspaper . en.
  18. 6 . Al-Sulaiti H, Diboun I, Agha MV, Mohamed FF, Atkin S, Dömling AS, Elrayess MA, Mazloum NA . October 2019 . Metabolic signature of obesity-associated insulin resistance and type 2 diabetes . Journal of Translational Medicine . 17 . 1 . 348 . 10.1186/s12967-019-2096-8 . 6805293 . 31640727 . free.
  19. Web site: December 2019 . WCM-Q research probes causal link between obesity and diabetes . Latest News - Weill Cornell Medicine - Qatar . en-US.
  20. 6 . Wang L, Shi W, Joyce MG, Modjarrad K, Zhang Y, Leung K, Lees CR, Zhou T, Yassine HM, Kanekiyo M, Yang ZY, Chen X, Becker MM, Freeman M, Vogel L, Johnson JC, Olinger G, Todd JP, Bagci U, Solomon J, Mollura DJ, Hensley L, Jahrling P, Denison MR, Rao SS, Subbarao K, Kwong PD, Mascola JR, Kong WP, Graham BS . July 2015 . Evaluation of candidate vaccine approaches for MERS-CoV . Nature Communications . 6 . 1 . 7712 . 2015NatCo...6.7712W . 10.1038/ncomms8712 . 4525294 . 26218507.
  21. 6 . Chemaitelly H, Yassine HM, Benslimane FM, Al Khatib HA, Tang P, Hasan MR, Malek JA, Coyle P, Ayoub HH, Al Kanaani Z, Al Kuwari E, Jeremijenko A, Kaleeckal AH, Latif AN, Shaik RM, Abdul Rahim HF, Nasrallah GK, Al Kuwari MG, Al Romaihi HE, Al-Thani MH, Al Khal A, Butt AA, Bertollini R, Abu-Raddad LJ . September 2021 . mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar . Nature Medicine . 27 . 9 . 1614–1621 . 10.1038/s41591-021-01446-y . 34244681 . 235786967 . free.
  22. 6 . Tang P, Hasan MR, Chemaitelly H, Yassine HM, Benslimane FM, Al Khatib HA, AlMukdad S, Coyle P, Ayoub HH, Al Kanaani Z, Al Kuwari E, Jeremijenko A, Kaleeckal AH, Latif AN, Shaik RM, Abdul Rahim HF, Nasrallah GK, Al Kuwari MG, Al Romaihi HE, Butt AA, Al-Thani MH, Al Khal A, Bertollini R, Abu-Raddad LJ . December 2021 . BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar . Nature Medicine . 27 . 12 . 2136–2143 . 10.1038/s41591-021-01583-4 . 34728831 . 241108406 . free . 10576/24856.
  23. 6 . Younes N, Al-Sadeq DW, Al-Jighefee H, Younes S, Al-Jamal O, Daas HI, Yassine HM, Nasrallah GK . May 2020 . Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2 . Viruses . 12 . 6 . 582 . 10.3390/v12060582 . 7354519 . 32466458 . free.
  24. 6 . Chemaitelly H, Tang P, Hasan MR, AlMukdad S, Yassine HM, Benslimane FM, Al Khatib HA, Coyle P, Ayoub HH, Al Kanaani Z, Al Kuwari E, Jeremijenko A, Kaleeckal AH, Latif AN, Shaik RM, Abdul Rahim HF, Nasrallah GK, Al Kuwari MG, Al Romaihi HE, Butt AA, Al-Thani MH, Al Khal A, Bertollini R, Abu-Raddad LJ . December 2021 . Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar . The New England Journal of Medicine . 385 . 24 . e83 . 10.1056/NEJMoa2114114 . 8522799 . 34614327.
  25. Abu-Raddad LJ, Chemaitelly H, Butt AA . July 2021 . Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants . The New England Journal of Medicine . 385 . 2 . 187–189 . 10.1056/NEJMc2104974 . 8117967 . 33951357.
  26. Web site: (BRC)- (QU) CONDUCTS SIX RESEARCH PROJECTS ON COVID-19 . 2020-03-28 . www.qu.edu.qa.
  27. Web site: 2020-03-29 . Qatar University's Biomedical Research Center conducting research on COVID-19 . The Peninsula Newspaper . en.
  28. Web site: 2020-03-28 . Qatar- QU conducts research on coronavirus . MENAFN.COM.
  29. 6 . Altarawneh HN, Chemaitelly H, Hasan MR, Ayoub HH, Qassim S, AlMukdad S, Coyle P, Yassine HM, Al-Khatib HA, Benslimane FM, Al-Kanaani Z, Al-Kuwari E, Jeremijenko A, Kaleeckal AH, Latif AN, Shaik RM, Abdul-Rahim HF, Nasrallah GK, Al-Kuwari MG, Butt AA, Al-Romaihi HE, Al-Thani MH, Al-Khal A, Bertollini R, Tang P, Abu-Raddad LJ . March 2022 . Protection against the Omicron Variant from Previous SARS-CoV-2 Infection . The New England Journal of Medicine . 386 . 13 . 1288–1290 . 10.1056/NEJMc2200133 . 8849180 . 35139269.
  30. 6 . Abu-Raddad LJ, Chemaitelly H, Ayoub HH, AlMukdad S, Yassine HM, Al-Khatib HA, Smatti MK, Tang P, Hasan MR, Coyle P, Al-Kanaani Z, Al-Kuwari E, Jeremijenko A, Kaleeckal AH, Latif AN, Shaik RM, Abdul-Rahim HF, Nasrallah GK, Al-Kuwari MG, Butt AA, Al-Romaihi HE, Al-Thani MH, Al-Khal A, Bertollini R . May 2022 . Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar . The New England Journal of Medicine . 386 . 19 . 1804–1816 . 10.1056/NEJMoa2200797 . 8929389 . 35263534.
  31. 6 . Altarawneh HN, Chemaitelly H, Ayoub HH, Tang P, Hasan MR, Yassine HM, Al-Khatib HA, Smatti MK, Coyle P, Al-Kanaani Z, Al-Kuwari E, Jeremijenko A, Kaleeckal AH, Latif AN, Shaik RM, Abdul-Rahim HF, Nasrallah GK, Al-Kuwari MG, Butt AA, Al-Romaihi HE, Al-Thani MH, Al-Khal A, Bertollini R, Abu-Raddad LJ . July 2022 . Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections . The New England Journal of Medicine . 387 . 1 . 21–34 . 10.1056/NEJMoa2203965 . 9258753 . 35704396.
  32. Web site: 2020-11-27 . Qatar- QUBRC records rapid growth in published medical resea... MENAFN.COM . menafn.com.
  33. Mohamed NA, Zupin L, Mazi SI, Al-Khatib HA, Crovella S . February 2023 . Nanomedicine as a Potential Tool against Monkeypox . Vaccines . 11 . 2 . 428 . 10.3390/vaccines11020428 . 9963669 . 36851305 . free.
  34. Mohamed NA, Abou-Saleh H, Mohamed HA, Al-Ghouti MA, Crovella S, Zupin L . July 2022 . Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2 . Viruses . 14 . 7 . 1553 . 10.3390/v14071553 . 9318803 . 35891532 . free.
  35. Mohamed NA, Marei I, Crovella S, Abou-Saleh H . January 2022 . Recent Developments in Nanomaterials-Based Drug Delivery and Upgrading Treatment of Cardiovascular Diseases . International Journal of Molecular Sciences . 23 . 3 . 1404 . 10.3390/ijms23031404 . 8836006 . 35163328 . free.
  36. Zakaria ZZ, Benslimane FM, Nasrallah GK, Shurbaji S, Younes NN, Mraiche F, Da'as SI, Yalcin HC . 6 . Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity . BioMed Research International . 2018 . 1642684 . 2018-09-27 . 30363733 . 10.1155/2018/1642684 . 6180974 . free .
  37. Yalcin HC, Benslimane FM, Kawakami K . The First International Zebrafish Conference/Workshop in Qatar . Zebrafish . 16 . 5 . 493–495 . October 2019 . 31453757 . 10.1089/zeb.2019.1786 . 201731365 .
  38. Web site: August 2021 . Utilization Of Zebrafish As An Animal Model . Qatar University .
  39. Web site: April 2017 . Qatar International Zebrafish Workshop . Qatar University .
  40. Web site: The Peninsula Newspaper. 2019-04-20 . Qatar University workshop introduces 'zebrafish model' research . en.
  41. Web site: 2023 . Facilities . Qatar University .
  42. Web site: 2019-04-14 . QU Paves the Way in Research in Zebra Fish . www.qu.edu.qa.
  43. Web site: 2019 . The First International Zebrafish Conference/Workshop in Qatar IZFS - International Zebrafish Society . www.izfs.org.
  44. Web site: 2020 . Policy on Zebrafish Research, Ministry of Public Health, Department of Research Regulation .
  45. Web site: Certek, biosafety laboratory, custom built modular laboratories, modular laboratory, biosafety, BSL-3 . 2023-03-15 . CERTEK . en.
  46. Al Khatib HA, Mathew S, Smatti MK, Eltai NO, Pathan SA, Al Thani AA, Coyle PV, Al Maslamani MA, Yassine HM . 6 . Profiling of Intestinal Microbiota in Patients Infected with Respiratory Influenza A and B Viruses . Pathogens . 10 . 6 . June 2021 . 761 . 34204203 . 8233933 . 10.3390/pathogens10060761 . free .
  47. Al Mana H, Sundararaju S, Tsui CK, Perez-Lopez A, Yassine H, Al Thani A, Al-Ansari K, Eltai NO . 6 . Whole-Genome Sequencing for Molecular Characterization of Carbapenem-Resistant Enterobacteriaceae Causing Lower Urinary Tract Infection among Pediatric Patients . Antibiotics . 10 . 8 . August 2021 . 972 . 34439022 . 8388976 . 10.3390/antibiotics10080972 . free .
  48. Boughattas S, Albatesh D, Al-Khater A, Giraldes BW, Althani AA, Benslimane FM . Whole genome sequencing of marine organisms by Oxford Nanopore Technologies: Assessment and optimization of HMW-DNA extraction protocols . Ecology and Evolution . 11 . 24 . 18505–18513 . December 2021 . 35003688 . 8717308 . 10.1002/ece3.8447 . 2021EcoEv..1118505B .

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