Binospirone Explained

Binospirone (MDL-73,005-EF) is a drug which acts as a partial agonist at 5-HT1A somatodendritic autoreceptors but as an antagonist at postsynaptic 5-HT1A receptors.[1] It has anxiolytic effects.[2]

See also

Notes and References

  1. Bertrand F, Lehmann O, Galani R, Lazarus C, Jeltsch H, Cassel JC . 8595441 . Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats . Pharmacology, Biochemistry, and Behavior . 68 . 4 . 647–60 . April 2001 . 11526961 . 10.1016/S0091-3057(01)00448-8 .
  2. Moser PC, Tricklebank MD, Middlemiss DN, Mir AK, Hibert MF, Fozard JR . Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam . British Journal of Pharmacology . 99 . 2 . 343–9 . February 1990 . 1970269 . 1917389 . 10.1111/j.1476-5381.1990.tb14706.x .

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