| William Jefferson | |
| Number: | 46, 30, 43 |
| Position: | Halfback |
| Birth Date: | 17 March 1918 |
| Birth Place: | Pheba, Mississippi, U.S. |
| Death Place: | Memphis, Tennessee, U.S. |
| Height Ft: | 6 |
| Height In: | 2 |
| Weight Lbs: | 208 |
| Draftyear: | 1941 |
| Draftround: | 12 |
| Draftpick: | 105 |
| High School: | Inverness (Inverness, Mississippi) |
| College: | Mississippi State |
| Pastteams: |
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| Pastcoaching: |
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| Statlabel1: | Games played |
| Statvalue1: | 19 |
| Statlabel2: | Rushing yards |
| Statvalue2: | 192 |
| Pfr: | JeffBi20 |
William C. Jefferson (March 17, 1918 – March 10, 1974) was an American football player and coach. He played professionally as a halfback in the National Football League (NFL) with the Detroit Lions in 1941 and the Brooklyn Dodgers and the Philadelphia Eagles in 1942.[1]