| Bill O'Brien | |
| Position: | Halfback |
| Birth Date: | 25 August 1924 |
| Birth Place: | Detroit |
| Death Place: | Eastport, Michigan |
| Height Ft: | 6 |
| Height In: | 0 |
| Weight Lbs: | 180 |
| High School: | University of Detroit Jesuit (MI) |
| Pastteams: | |
| Statlabel1: | Games |
| Statvalue1: | 9 |
| Pfr: | OBriBi20 |
William George O'Brien (August 25, 1924 – May 8, 2005) was an American football player.
Born in Detroit, O'Brien attended University of Detroit Jesuit High School. He played professional football in the National Football League as a halfback for the Detroit Lions. He appeared in nine games for the Lions during the 1947 season.[1]