Bile-acid 7alpha-dehydroxylase explained

Bile-acid 7alpha-dehydroxylase
Ec Number:	1.17.99.5

Bile-acid 7alpha-dehydroxylase (cholate 7alpha-dehydroxylase, 7alpha-dehydroxylase, bile acid 7-dehydroxylase) was thought to be an enzyme with systematic name deoxycholate:NAD⁺ oxidoreductase.^{[1] [2] [3] [4]}

However, it was later shown that the dehydroxylation is carried out by seven different enzymes, catalyzing a total of 8 reactions. The enzymes are,,,,,, and .

Notes and References

1. White BA, Cacciapuoti AF, Fricke RJ, Whitehead TR, Mosbach EH, Hylemon PB . Cofactor requirements for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708 . Journal of Lipid Research . 22 . 6 . 891–8 . August 1981 . 7276750 .
2. White BA, Paone DA, Cacciapuoti AF, Fricke RJ, Mosbach EH, Hylemon PB . Regulation of bile acid 7-dehydroxylase activity by NAD+ and NADH in cell extracts of Eubacterium species V.P.I. 12708 . Journal of Lipid Research . 24 . 1 . 20–7 . January 1983 . 6833878 .
3. Coleman JP, White WB, Hylemon PB . Molecular cloning of bile acid 7-dehydroxylase from Eubacterium sp. strain VPI 12708 . Journal of Bacteriology . 169 . 4 . 1516–21 . April 1987 . 3549693 . 211977 .
4. Russell DW . The enzymes, regulation, and genetics of bile acid synthesis . Annual Review of Biochemistry . 72 . 137–74 . 2003 . 12543708 . 10.1146/annurev.biochem.72.121801.161712 .