| Official Name: | Big Isaac, West Virginia |
| Pushpin Map: | West Virginia#USA |
| Pushpin Label: | Big Isaac |
| Subdivision Type: | Country |
| Subdivision Type1: | State |
| Subdivision Type2: | County |
| Subdivision Name2: | Doddridge |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 984 |
| Coordinates: | 39.2°N -80.5386°W |
| Area Codes: | 304 & 681 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 1535868[1] |
Big Isaac is an unincorporated community in Doddridge County, West Virginia, United States. Big Isaac is 6miles south-southeast of Salem, along Laurel Run, a headwaters tributary of Meathouse Fork.[2] The Big Isaac post office closed on December 31, 1962.[3]
According to tradition, the community bears the name of Periue "Big" Isaac, an early settler noted for his especially large shoe size.[4]