| Big Buffalo Creek | |
| Name Other: | Tributary to Deep River |
| Map Size: | 300 |
| Pushpin Map: | USA North Carolina#USA |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of Big Buffalo Creek mouth |
| Pushpin Map Alt: | Map of Big Buffalo Creek mouth location |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | North Carolina |
| Subdivision Type3: | County |
| Subdivision Name3: | Lee |
| Subdivision Type4: | City |
| Subdivision Name4: | Sanford |
| Length: | 7.48miles[1] |
| Discharge1 Location: | Deep River |
| Discharge1 Avg: | 23.35cuft/s at mouth with Deep River[2] |
| Source1: | confluence of Skunk Creek and Persimmon Creek |
| Source1 Location: | Sanford, North Carolina |
| Source1 Coordinates: | 35.4758°N -79.1967°W[3] |
| Source1 Elevation: | 285feet[4] |
| Mouth: | Deep River |
| Mouth Location: | about 0.25 miles southeast of Cumnock, North Carolina |
| Mouth Coordinates: | 35.5522°N -79.2261°W |
| Mouth Elevation: | 205feet |
| Progression: | Deep River → Cape Fear River → Atlantic Ocean |
| River System: | Deep River |
| Tributaries Left: | Persimmon Creek Purgatory Branch |
| Tributaries Right: | Skunk Creek |
| Bridges: | US1-US15, Carbonton Road, Old Carbonton Road, Spring Lane, US 421, McNeill Road, US 421, Cotten Road |
Big Buffalo Creek is a 20.28miles long 3rd order tributary to the Deep River in Lee County, North Carolina.
Big Buffalo Creek is formed at the confluence of Skunk Creek and Persimmon Creek in Sanford, North Carolina and then flows northwest to the Deep River about 0.25 miles southeast of Cumnock, North Carolina.[5]
Big Buffalo Creek drains of area, receives about 47.7 in/year of precipitation, and has a wetness index of 418.37 and is about 42% forested.[2]