Bicyclic phosphate explained

Bicyclic phosphate is a class of organophosphate compounds that are used as flame retardants, stabilizers and antioxidants. They are also used in spectroscopic studies.^{[1] [2]}

Some bicyclic phosphates, such as TBPS, TBPO and IPTBO, are highly toxic. They have toxicity comparable to nerve agents. However, they are not acetylcholinesterase inhibitors. They act as GABA receptor antagonists and have potent convulsant effects.^{[3] [4]}

See also

• Convulsant
• TBPS
• TBPO
• IPTBO

Notes and References

1. Bellet . E. M. . Casida . J. E. . Bicyclic Phosphorus Esters: High Toxicity without Cholinesterase Inhibition . Science . 14 December 1973 . 182 . 4117 . 1135–1136 . 10.1126/science.182.4117.1135. 1973Sci...182.1135B . 4356280 . 9462533 .
2. Book: Gupta . Ramesh C. . Handbook of toxicology of chemical warfare agents . 2009 . Academic Press . London . 9780123744845 . 1st .
3. BOWERY . N. G. . COLLINS . J. F. . HILL . R. G. . Bicyclic phosphorus esters that are potent convulsants and GABA antagonists . Nature . 17 June 1976 . 261 . 5561 . 601–603 . 10.1038/261601a0. 934303 . 1976Natur.261..601B . 4184150 .
4. Book: Ellison . D. Hank . Handbook of chemical and biological warfare agents . 2007 . CRC . Boca Raton, Fla. . 9780849314346 . 2nd .