Bglg-cis-reg RNA explained

bglG-cis-reg
Symbol:	bglG-cis-reg
Rfam:	RF03530
Rna Type:	Cis-reg

The bglG cis regulatory RNA was identified by RNA deep sequencing of Clostridioides difficile 630 ^[1] where it is located immediately upstream of gene bglG2. BglG2 is an antiterminator protein involved in the regulation of genes of the Beta-glucoside phosphotransferase system in.^[2] Homologues of the C. difficile element were found across Clostridiales and other Bacillota. The element is consistently located 5’ of bglG2 or LicT, another antiterminator of the Beta-Glucoside Phosphotransferase System [2], consistent with a cis-regularly function at these operons. Only Clostridiales sequences were included in the seed alignment. Sequence is named S0591 in ref.^[3]

Notes and References

1. Soutourina OA, Monot M, Boudry P, Saujet L, Pichon C, Sismeiro O . etal. Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile. . PLOS Genet . 2013 . 9 . 5 . e1003493 . 23675309 . 10.1371/journal.pgen.1003493 . 3649979 . free.
2. Tanaka Y, Teramoto H, Inui M, Yukawa H. Translation efficiency of antiterminator proteins is a determinant for the difference in glucose repression of two β-glucoside phosphotransferase system gene clusters in Corynebacterium glutamicum R. . J Bacteriol . 2011 . 193 . 2 . 349–57 . 21075922 . 10.1128/JB.01123-10 . 3019825 .
3. Soutourina OA, Monot M, Boudry P, Saujet L, Pichon C, Sismeiro O . etal. Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile. . PLOS Genet . 2013 . 9 . 5 . e1003493 . 23675309 . 10.1371/journal.pgen.1003493 . 3649979 . free.