Bezisterim Explained

Legal Status:Investigational
Synonyms:NE3107; HE3286
Cas Number:1001100-69-1
Pubchem:16739648
Chemspiderid:20571043
Drugbank:DB05212
Unii:PH8858757I
Kegg:D12932
Chembl:4297284
Iupac Name:(3S,7R,8R,9S,10R,13S,14S,17R)-17-Ethynyl-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[''a'']phenanthrene-3,7,17-triol
C:21
H:30
O:3
Stdinchi:1S/C21H30O3/c1-4-21(24)10-7-16-18-15(6-9-20(16,21)3)19(2)8-5-14(22)11-13(19)12-17(18)23/h1,12,14-18,22-24H,5-11H2,2-3H3/t14-,15-,16-,17-,18+,19-,20-,21-/m0/s1
Stdinchikey:JJKOQZHWYLMASZ-FJWDNACWSA-N
Smiles:C[C@]12CC[C@@H](CC1=C[C@@H]([C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C#C)O)C)O)O

Bezisterim (NE3107) is an analog of androstenetriol that is believed to have anti-inflammatory and insulin-sensitizing effects in the brain. The compound crosses the blood-brain barrier and does not activate any neurotransmitter receptors.[1] It has been tested as a treatment for Alzheimer's disease[2] [3] [4] [5] and traumatic brain injury.[6]

Notes and References

  1. Reading . Chris L . Ahlem . Clarence N . Parameswaran . Narayanan . Rationale for an anti-inflammatory insulin sensitizer in a phase 3 Alzheimer's disease trial . Alzheimer's & Dementia . December 2021 . 17 . S9 . 10.1002/alz.057438. free .
  2. Stoiljkovic . Milan . Horvath . Tamas L. . Hajós . Mihály . Therapy for Alzheimer's disease: Missing targets and functional markers? . Ageing Research Reviews . July 2021 . 68 . 101318 . 10.1016/j.arr.2021.101318. 33711510 . 8131215 .
  3. Balzano . Tiziano . Esteban-García . Noelia . Blesa . Javier . Neuroinflammation, immune response and α-synuclein pathology: how animal models are helping us to connect dots . Expert Opinion on Drug Discovery . 2 January 2023 . 18 . 1 . 13–23 . 10.1080/17460441.2023.2160440. 36538833 . 254959175 .
  4. Liu . Ping . Wang . Yunyun . Sun . Yan . Peng . Guoping . Neuroinflammation as a Potential Therapeutic Target in Alzheimer's Disease . Clinical Interventions in Aging . April 2022 . 17 . 665–674 . 10.2147/CIA.S357558 . 35520949 . 9064449 . free .
  5. Xi . Yilong . Chen . Yun . Jin . Yi . Han . Guochen . Song . Mingjie . Song . Tingting . Shi . Yang . Tao . Ling . Huang . Zewei . Zhou . Jianping . Ding . Yang . Zhang . Huaqing . Versatile nanomaterials for Alzheimer's disease: Pathogenesis inspired disease-modifying therapy . Journal of Controlled Release . May 2022 . 345 . 38–61 . 10.1016/j.jconrel.2022.02.034. 35257810 . 247285338 .
  6. "U.S. Clinical Trial: Neurological Associates of West Los Angeles Listed a New Clinical Trial to Study Insulin-sensitizing NE3107 in Improving Sleep and Fatigue in Subjects With Traumatic Brain Injury." Contify Life Science News, 1 Aug. 2023, p. NA. Gale OneFile: Health and Medicine, link.gale.com/apps/doc/A759542006/HRCA?u=anon~bb46c85&sid=sitemap&xid=0c315c7e. Accessed 14 Dec. 2023.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Bezisterim".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.