Betty Diamond Explained

Betty Diamond
Birth Date:11 May 1948
Birth Place:Hartford, CT
Nationality:American
Known For:Medical Research
Education:Radcliffe College, Harvard Medical School
Employer:The Feinstein Institute for Medical Research
Occupation:Physician, Scientist

Betty Diamond (born 11 May 1948, in Hartford, Connecticut) is an American physician and researcher. She is director of the Institute of Molecular Medicine at Northwell Health's Feinstein Institute for Medical Research in Manhasset, NY. She was elected a member of the National Academy of Sciences in 2022.[1]

Education

Betty Diamond received her B.A. in Art History (Magna Cum) from Radcliffe College in 1969 and her M.D. from Harvard Medical School in 1973. In 1976 she began her residency at Columbia Presbyterian Medical Center, New York, NY and in 1979 embarked on post-doctoral fellowship in Immunology with Dr. Matthew Scharff at the Albert Einstein College of Medicine, Bronx, NY.[2] [3]

Academic career

Diamond has been on the faculty and chief of rheumatology at both Einstein and Columbia. She is currently head of the Center for Autoimmune and Musculoskeletal Disease at The Feinstein Institute for Medical Research and Professor of Molecular Medicine at Hofstra Northwell School of Medicine.[2] [3] She has been on the board of the American College of Rheumatology, is past president of the American Association of Immunology, and is a member of the Institute of Medicine. She is also past chair of the scientific advisory board of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and has been on their Scientific Council.[4] [5] [6]

Diamond helped to establish (and named) the Advancing Women in Science and Medicine group at the Feinstein Institutes in 2010. AWSM (pronounced “awesome”) uses philanthropic support to help advance the careers of women scientists, countering gender bias and increasing gender equity.[7] [2]

Research

Diamond's primary interests are in the mechanisms of central and peripheral tolerance of autoreactive B cells,[8] [9] and the defects in these mechanisms that are present in autoimmune disease, as well as the role of antibodies in brain disease.[10] [11] Diamond identified the first idiotype marker on anti-DNA antibodies in patients with lupus,[12] [13] and discovered that anti-DNA antibodies in patients and mice shared characteristics with antibodies to pneumococcal polysaccharide. Diamond showed that a single base change in a protective anti-pneumococcal antibody could convert it into a potentially pathogenic anti-DNA antibody. She also found that a peptide that binds to 50% of anti-DNA antibodies in lupus patients and mice represents an epitope on glutamate receptors of the brain and can destroy neurons. Antibodies against the epitope are present in the cerebrospinal fluid and in brain tissue of patients with neuropsychiatric lupus.[14] [15] Her work provides a mechanism for aspects of neuropsychiatric lupus, and more generally for acquired changes in cognition and behavior.[16] [17] [18] [19] Diamond also studies the role that hormones may play in the development of lupus.[20] [21] [2]

Selected awards and honors

Notes and References

  1. News: Zeller . Gregory . Feinstein's Diamond, SBU math whiz earn NAS nods - Innovate Long Island . 28 April 2023 . Innovateli . 10 May 2022.
  2. Diamond . Betty . Not Dead Yet . Annual Review of Immunology . 26 April 2023 . 41 . 1 . 1–15 . 10.1146/annurev-immunol-101721-065214 . 37126416 . 258368440 . 0732-0582. free .
  3. Web site: Betty Diamond, MD . Feinstein Institutes for Medical Research . 28 April 2023 .
  4. Web site: Our Team . Autoimmune Association . 28 April 2023.
  5. Web site: Betty Diamond, MD Scientific Advisory Board . Arthritis National Research Foundation Funding Research To Cure Arthritis . 28 April 2023.
  6. Web site: Molecular Medicine An Interview with Betty Diamond . Leaders Online . 2020 . 28 April 2023.
  7. Web site: Allen . Julianne Mosher . Betty Diamond receives Women in Medicine and Science Leadership Award Northwell Health . Northwell Health News . 3 October 2022 . 1 May 2023 .
  8. Venkatesh . Jeganathan . Peeva . Elena . Xu . Xiaonan . Diamond . Betty . Cutting Edge: Hormonal Milieu, Not Antigenic Specificity, Determines the Mature Phenotype of Autoreactive B Cells . The Journal of Immunology . 15 March 2006 . 176 . 6 . 3311–3314 . 10.4049/jimmunol.176.6.3311 . 16517697 . 1255454 . free .
  9. Book: Coico . Richard . Sunshine . Geoffrey . Immunology: A Short Course . 14 January 2009 . John Wiley & Sons . 978-0-470-08158-7 .
  10. Web site: Meislin . Margy . LRA and LT Congratulate Betty Diamond, MD on Election to the National Academy of Sciences . Lupus Research . 28 April 2023 . 11 May 2022.
  11. Kowal . Czeslawa . DeGiorgio . Lorraine A. . Lee . Ji Y. . Edgar . Mark A. . Huerta . Patricio T. . Volpe . Bruce T. . Diamond . Betty . Human lupus autoantibodies against NMDA receptors mediate cognitive impairment . Proceedings of the National Academy of Sciences . 26 December 2006 . 103 . 52 . 19854–19859 . 10.1073/pnas.0608397104 . 17170137 . 1702320 . 0027-8424 . free .
  12. Halpern . R . Schiffenbauer . J . Solomon . G . Diamond . B . Detection of masked anti-DNA antibodies in lupus sera by a monoclonal anti-idiotype . The Journal of Immunology . 1 October 1984 . 133 . 4 . 1852–1856 . 10.4049/jimmunol.133.4.1852 . 6332136 . 25611127 . 0022-1767. free .
  13. Kohler . Heinz . Superantibodies . Applied Biochemistry and Biotechnology . 2000 . 83 . 1–3 . 1–12 . 10.1385/ABAB:83:1-3:1 . 10826945 .
  14. Kivity . Shaye . Katzav . Aviva . Arango . Maria Teresa . Landau-Rabi . Moran . Zafrir . Yaron . Agmon-Levin . Nancy . Blank . Miri . Anaya . Juan-Manuel . Mozes . Edna . Chapman . Joab . Shoenfeld . Yehuda . 16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus . BMC Medicine . 4 April 2013 . 11 . 1 . 90 . 10.1186/1741-7015-11-90 . 23556432 . 3616817 . 1741-7015 . free .
  15. Bosch . Xavier . Ramos-Casals . Manuel . Khamashta . Munther A. . The DWEYS peptide in systemic lupus erythematosus . Trends in Molecular Medicine . April 2012 . 18 . 4 . 215–223 . 10.1016/j.molmed.2012.01.008 . 22365619 . 1471-4914.
  16. Stock . AD . Wen . J . Putterman . C . Neuropsychiatric Lupus, the Blood Brain Barrier, and the TWEAK/Fn14 Pathway. . Frontiers in Immunology . 25 December 2013 . 4 . 484 . 10.3389/fimmu.2013.00484 . 24400009 . 3872310 . 1664-3224 . free .
  17. News: Jancin . Bruce . ACE inhibitors may improve neuropsychiatric lupus . 28 April 2023 . MDedge Rheumatology . 13 April 2019 .
  18. Kivity . Shaye . Agmon-Levin . Nancy . Zandman-Goddard . Gisele . Chapman . Joab . Shoenfeld . Yehuda . Neuropsychiatric lupus: a mosaic of clinical presentations . BMC Medicine . 4 March 2015 . 13 . 1 . 43 . 10.1186/s12916-015-0269-8 . 25858312 . 4349748 . 1741-7015 . free .
  19. Govoni . Marcello . Hanly . John G . The management of neuropsychiatric lupus in the 21st century: still so many unmet needs? . Rheumatology . 5 December 2020 . 59 . Supplement_5 . v52–v62 . 10.1093/rheumatology/keaa404 . 33280014 . 7719041 .
  20. Diamond . Betty . Huerta . Patricio T. . Mina-Osorio . Paola . Kowal . Czeslawa . Volpe . Bruce T. . Losing your nerves? Maybe it's the antibodies . Nature Reviews Immunology . June 2009 . 9 . 6 . 449–456 . 10.1038/nri2529 . 19424277 . 2783680 . 1474-1741.
  21. Petri . M . Sex hormones and systemic lupus erythematosus . Lupus . May 2008 . 17 . 5 . 412–415 . 10.1177/0961203308090026 . 18490418 . 7730215 . 0961-2033.
  22. News: American College of Rheumatology . American College of Rheumatology announces 2022 award recipients . 28 April 2023 . EurekAlert! . 11 October 2022 .
  23. Web site: National Academy of Sciences Elects Members and International Members . NAS Online . National Academy of Sciences . 3 May 2022 . 14 July 2022.
  24. News: Feinstein Institutes' Betty Diamond Elected to the National Academy of Sciences . 28 April 2023 . Businesswire . 4 May 2022 .
  25. News: Allen . Julianne Mosher . Feinstein Institutes' Betty Diamond receives Women in Medicine and Science Leadership Award . 28 April 2023 . Businesswire . 3 October 2022 .
  26. News: Quinn . Richard . ACR Honors Contributions to Rheumatology - Page 3 of 10 . 28 April 2023 . The Rheumatologist . 13 January 2012.
  27. Web site: Evelyn V. Hess, MD, MACP, MACR Award . Lupus Foundation of America . 28 April 2023 .
  28. Web site: Betty A. Diamond, M.D. . The American Association of Immunologists . 28 April 2023.
  29. Web site: AAAS Fellows . American Association for the Advancement of Science . 28 April 2023.
  30. Web site: About Us: Scientific Advisors. Lupus Research Institute. 1 August 2011. https://web.archive.org/web/20110727052014/http://www.lupusresearchinstitute.org/about/scientific_advisors. 27 July 2011. dead.
  31. Web site: Alumni Awards . Alumni Albert Einstein College of Medicine . 28 April 2023.
  32. Web site: Past Howley Prize Recipients . The Arthritis Foundation . 28 April 2023 .
  33. Web site: ACR Past Awards of Distinction Recipients. American College of Rheumatology. 1 August 2011.
  34. Web site: New Investigators Supported. S.L.E. Lupus Foundation. 1 August 2011. https://web.archive.org/web/20110814003342/http://www.lupusny.org/lupus-research/investigators#2000. 14 August 2011. dead.

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