Betaine-aldehyde dehydrogenase explained

betaine-aldehyde dehydrogenase
Ec Number:	1.2.1.8
Cas Number:	9028-90-4
Go Code:	0008802
Width:	270

In enzymology, a betaine-aldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction

betaine aldehyde + NAD⁺ + H₂O

\rightleftharpoons betaine + NADH + 2 H⁺

The 3 substrates of this enzyme are betaine aldehyde, NAD⁺, and H₂O, whereas its 3 products are betaine, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is betaine-aldehyde:NAD+ oxidoreductase. Other names in common use include betaine aldehyde oxidase, BADH, betaine aldehyde dehydrogenase, and BetB. This enzyme participates in glycine, serine and threonine metabolism.

Structural studies

, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .

References

• ROTHSCHILD HA, BARRON ES . 1954 . The oxidation of betaine aldehyde by betaine aldehyde dehydrogenase . J. Biol. Chem. . 209 . 511 - 23 . 13192104 . 2 . 10.1016/S0021-9258(18)65478-X . free .
• Tsutui N, Hirasawa E . 2003 . Purification and properties of betaine aldehyde dehydrogenase from Avena sativa . J. Plant Res. . 116 . 133 - 40 . 12736784 . 10.1007/s10265-003-0077-7 . 2 . 2003JPlR..116..133L . 23668905 .
• L . 2003 . Ligand-induced conformational changes of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves affecting the reactivity of the catalytic thiol . Chem. Biol. Interact. . 143-144 . 129 - 37 . 12604197 . 10.1016/S0009-2797(02)00197-7 . González-Segura . L . Mújica-Jiménez . C . Contreras-Díaz . L . 2003CBI...143..129M .
• Eklund H . 1998 . Structure of betaine aldehyde dehydrogenase at 2.1 A resolution . Protein Sci. . 7 . 2106 - 17 . 9792097 . El-Ahmad . M . Ramaswamy . S . Hjelmqvist . L . Jörnvall . H . Eklund . H . 10 . 2143847 . 10.1002/pro.5560071007 .
• Takabe T . 2003 . Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica . J. Biol. Chem. . 278 . 4932 - 42 . 12466265 . 10.1074/jbc.M210970200 . Tanaka . Y . Aoki . K . Hibino . T . Jikuya . H . Takano . J . Takabe . T . Takabe . T . 7 . free .