Beta-ketoacyl-ACP synthase II explained

Beta-ketoacyl-acyl-carrier-protein synthase II
Ec Number:	2.3.1.179

In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase II is an enzyme that catalyzes the chemical reaction

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein]

\rightleftharpoons (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO₂ + [acyl-carrier-protein]

Thus, the two substrates of this enzyme are (Z)-hexadec-11-enoyl-[acyl-carrier-protein] and malonyl-[acyl-carrier-protein], whereas its 3 products are (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein], CO₂, and acyl-carrier-protein.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is (Z)-hexadec-11-enoyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-pr otein] C-acyltransferase (decarboxylating). Other names in common use include KASII, KAS II, FabF, 3-oxoacyl-acyl carrier protein synthase I, and beta-ketoacyl-ACP synthase II. This enzyme participates in fatty acid biosynthesis.

References

• D'Agnolo G, Rosenfeld IS, Vagelos PR . 1975 . Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli . J. Biol. Chem. . 250 . 5289 - 94 . 237914 . 14 .
• Garwin JL, Klages AL, ((Cronan JE Jr)) . 1980 . Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli . J. Biol. Chem. . 255 . 11949 - 56 . 7002930 . 24 .
• Price AC, Rock CO, White SW . 2003 . The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae . J. Bacteriol. . 185 . 4136 - 43 . 12837788 . 10.1128/JB.185.14.4136-4143.2003 . 14 . 164876 .
• Garwin JL, Klages AL, ((Cronan JE Jr)) . 1980 . Beta-ketoacyl-acyl carrier protein synthase II of Escherichia coli Evidence for function in the thermal regulation of fatty acid synthesis . J. Biol. Chem. . 255 . 3263 - 5 . 6988423 . 8 .
• Magnuson K, Carey MR, ((Cronan JE Jr)) . 1995 . The putative fabJ gene of Escherichia coli fatty acid synthesis is the fabF gene . J. Bacteriol. . 177 . 3593 - 5 . 7768872 . 12 . 177068 . 10.1128/jb.177.12.3593-3595.1995 .
• Neidhardt, F.C. (Ed.), Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed., vol. 1, ASM Press, Washington, DC, 1996, p. 612-636.