Beta-amyrin 11-oxidase explained
Beta-amyrin 11-oxidase |
Ec Number: | 1.14.13.134 |
Beta-amyrin 11-oxidase (CYP88D6) is an enzyme with systematic name beta-amyrin,NADPH:oxygen oxidoreductase (hydroxylating).[1] This enzyme catalyses the following chemical reaction
beta-amyrin + 2 O2 + 2 NADPH + 2 H+
11-oxo-beta-amyrin + 3 H
2O + 2 NADP
+ (overall reaction)
(1a) beta-amyrin + O2 + NADPH + H+
11alpha-hydroxy-beta-amyrin + H
2O + NADP
+(1b) 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+
11-oxo-beta-amyrin + 2 H
2O + NADP
+Beta-amyrin 11-oxidase requires cytochrome P450.
Notes and References
- Seki H, Ohyama K, Sawai S, Mizutani M, Ohnishi T, Sudo H, Akashi T, Aoki T, Saito K, Muranaka T . Licorice beta-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin . Proceedings of the National Academy of Sciences of the United States of America . 105 . 37 . 14204–9 . September 2008 . 18779566 . 2532699 . 10.1073/pnas.0803876105 . 2008PNAS..10514204S . free .