Β-Hydroxybutyryl-CoA explained

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β-Hydroxybutyryl-CoA (or 3-hydroxybutyryl-coenzyme A) is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan.^{[1] [2]} The L-3-hydroxybutyl-CoA (or (S)-3-hydroxybutanoyl-CoA) enantiomer is also the second to last intermediate in beta oxidation of even-numbered, straight chain, and saturated fatty acids.^[3]

See also

• Crotonyl-coenzyme A
• Acetoacetyl CoA
• Beta-hydroxybutyryl-CoA dehydrogenase

Notes and References

1. Numa . S. . Ishimura . Y. . Nishizuka . Y. . Hayaishi . O. . 1961-10-23 . beta-Hydroxybutyryl-CoA, an intermediate in glutarate catabolism . Biochemical and Biophysical Research Communications . 6 . 38–43 . 10.1016/0006-291x(61)90181-4 . 0006-291X . 14480702.
2. Liu . Shumeng . Yu . Huajing . Liu . Yongqing . Liu . Xinhua . Zhang . Yu . Bu . Chen . Yuan . Shuai . Chen . Zhe . Xie . Guojia . Li . Wanjin . Xu . Bosen . Yang . Jianguo . He . Lin . Jin . Tong . Xiong . Yundong . 2017-09-07 . Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis . Molecular Cell . 67 . 5 . 853–866.e5 . 10.1016/j.molcel.2017.07.011 . 1097-4164 . 28803779. free .
3. van Rijt . Willemijn J. . Van Hove . Johan L. K. . Vaz . Frédéric M. . Havinga . Rick . Allersma . Derk P. . Zijp . Tanja R. . Bedoyan . Jirair K. . Heiner-Fokkema . M. R. . Reijngoud . Dirk-Jan . Geraghty . Michael T. . Wanders . Ronald J. A. . Oosterveer . Maaike H. . Derks . Terry G. J. . July 2021 . Enantiomer-specific pharmacokinetics of D,L-3-hydroxybutyrate: Implications for the treatment of multiple acyl-CoA dehydrogenase deficiency . Journal of Inherited Metabolic Disease . 44 . 4 . 926–938 . 10.1002/jimd.12365 . 1573-2665 . 8359440 . 33543789.