Benzylthiouracil Explained

Benzylthiouracil (BTU) is an antithyroid preparation. It is a thioamide, closely related to propylthiouracil.

Adverse effects

Benzylthiouracil has been associated with severe adverse effects, notably vasculitis and subsequent ANCA-positive glomerulonephritis, as well as isolated reports of lung damage.^{[1] [2] [3] [4]}

Notes and References

1. Tieulie N, Huong DL, Andreu M . [ANCA associated glomerulonephritis related to benzylthiouracil] . French . Rev Méd Interne . 23 . 10 . 853–6 . 2002 . 12428489 . 10.1016/S0248-8663(02)00694-X. etal.
2. Kaaroud H, Khiari K, Ben Moussa F, Barbouch S, Boussema E, Ben Maïz H . [Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease] . French . Rev Méd Interne . 23 . 10 . 857–61 . 2002 . 12428490 . 10.1016/S0248-8663(02)00704-X.
3. Braham A, Houman MH, Rais L, Ben Gborbel I, Lamloum M, Miled M . [Benzylthiouracil induced ANCA-positive vasculitis] . French . Presse Médicale . 33 . 19 Pt 1 . 1331–3 . 2004 . 15615240 . 10.1016/S0755-4982(04)98919-1.
4. Thabet F, Sghiri R, Tabarki B, Ghedira I, Yacoub M, Essoussi AS . ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil . Eur J Pediatr . 165 . 7 . 435–6 . 2006 . 16622664 . 10.1007/s00431-005-0053-4.