Benzoyl-CoA-dihydrodiol lyase explained

Benzoyl-CoA-dihydrodiol lyase
Ec Number:	4.1.2.44

Benzoyl-CoA-dihydrodiol lyase (2,3-dihydro-2,3-dihydroxybenzoyl-CoA lyase/hydrolase (deformylating), BoxC, dihydrodiol transforming enzyme, benzoyl-CoA oxidation component C) is an enzyme with systematic name 2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA semialdehyde-lyase (formate-forming).^[1] This enzyme catalyses the following chemical reaction

2,3-dihydro-2,3-dihydroxybenzoyl-CoA + H₂O

\rightleftharpoons 3,4-didehydroadipyl-CoA semialdehyde + formate

The enzyme is involved in the aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii.

Notes and References

1. Gescher J, Eisenreich W, Wörth J, Bacher A, Fuchs G . Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme . Molecular Microbiology . 56 . 6 . 1586–600 . June 2005 . 15916608 . 10.1111/j.1365-2958.2005.04637.x . free .