Benzocyclobutadiene Explained

Benzocyclobutadiene should not be confused with benzocyclobutene.

Benzocyclobutadiene is the simplest polycyclic hydrocarbon, being composed of an aromatic benzene ring fused to an anti-aromatic cyclobutadiene ring. It has chemical formula . Though the benzene ring is stabilized by aromaticity, the cyclobutadiene portion has a destabilizing effect. This results into it being a non-aromatic compound - neither behaving as aromatic nor an antiaromatic one.[1] For this reason, benzocyclobutadiene will readily dimerize or polymerize and it reacts as a dienophile in Diels-Alder reactions.[2]

Benzocyclobutadiene is used in the production of the pharmaceutical drug naflocort.

See also

Notes and References

  1. Observation of benzocyclobutadiene by flow nuclear magnetic resonance https://doi.org/10.1021/ja00168a059
  2. Book: Carey, Francis A. . Sundberg, Richard J. . 1984 . Advanced Organic Chemistry Part A Structure and Mechanisms . 2nd . New York, NY . Plenum Press . 0-306-41198-9.