| Benizelos Roufos | |
| Office1: | Prime Minister of Greece |
| Term Start1: | 29 April 1863 |
| Term End1: | 18 October 1863 (o.s.) |
| Monarch1: | vacant |
| Predecessor1: | Diomidis Kyriakos |
| Successor1: | Dimitrios Voulgaris |
| Term Start2: | 28 November 1865 |
| Term End2: | 9 June 1866 (o.s.) |
| Monarch2: | George I |
| Predecessor2: | Epameinondas Deligeorgis |
| Successor2: | Dimitrios Voulgaris |
| Birth Date: | 1795 |
| Birth Place: | Patras, Morea Eyalet, Ottoman Empire (now Greece) |
| Death Date: | 18 March 1868 (aged 73) |
| Death Place: | Patras, Kingdom of Greece |
| Nationality: | Greek |
| Battles: | Greek War of Independence |
| Relations: | Athanasios Kanakaris |
| Allegiance: | First Hellenic Republic |
Benizelos Roufos (; 1795–1868) was a Greek politician and Prime Minister of Greece.
Roufos was born in Patras in 1795, a scion of the wealthy Roufos-Kanakaris family. He was the son of Athanasios Kanakaris who fought during the Greek War of Independence.
During the government of Ioannis Kapodistrias (1828–1830), Roufos became governor of Elis. Later he would also serve as Foreign Minister. In 1855, Roufos was elected Mayor of Patras, a post he held for three years.
When King Otto was exiled in 1862 as a result of a revolution, Roufos became one of three viceroys - along with Konstantinos Kanaris and Dimitrios Voulgaris - that held power from 10 October 1862 until 19 October 1863.[1] Roufos served twice as Prime Minister of Greece, with his first term interrupted for a few days in June 1863.[2]
Roufos died in Patras on 18 March 1868.