Benita Katzenellenbogen Explained

Benita S. Katzenellenbogen
Birth Name:Benita Schulman
Birth Date:April 11, 1945
Birth Place:New York City
Nationality:American
Alma Mater:Harvard University
Occupation:Cell biologist

Benita S. Katzenellenbogen née Schulman (born 1945) is an American physiologist and cell biologist at the University of Illinois at Urbana-Champaign. She has studied cancer, endocrinology, and women's health, focusing on nuclear receptors. She also dedicated efforts to focusing on improving the effectiveness of endocrine therapies in breast cancer.

Biography

Katzenellenbogen's work has delineated structure-function relationships and mechanisms of action of estrogen receptors alpha and beta. She has clarified the molecular basis of action of SERMs such as tamoxifen and raloxifene in treatment and prevention of breast cancer, and she has identified critical aggressiveness factors in breast tumors that promote metastasis and resistance to cancer therapies. She has studied approaches to inhibit them.[1] [2]

Early life

Benita Schulman was born April 11, 1945, in New York City. Her father was a patent attorney and her mother was a school teacher in New York. She attended public schools and did her undergraduate training in biology at the City University of New York (Brooklyn College), receiving her BA summa cum laude in 1965. She obtained her Ph.D. in biology at Harvard University in 1970, doing research in Developmental Biology with Professor Fotis Kafatos.[3] [4] She completed postdoctoral work in endocrinology and cancer biology at the University of Illinois at Urbana-Champaign from 1970 to 1971 with Professor Jack Gorski.[5] [6]

Career

Katzenellenbogen began her academic career as an Assistant Professor of Physiology at the University of Illinois and College of Medicine at Urbana-Champaign in 1971. She was promoted to Associate Professor in 1976, and to Full Professor in 1982. She is currently the Swanlund Professor of Molecular and Integrative Physiology, Cell and Developmental Biology at the University of Illinois. She also holds affiliate appointments in the Institute for Genomic Biology[7] and the Beckman Institute for Advanced Science and Technology at Illinois.[8] Additionally, from September 1977 to June 1978, Katzenellenbogen did sabbatical research at the University of California at San Francisco, and in 2005 she conducted collaborative sabbatical research at the Genome Institute of Singapore.[9] Her professional career has been directed at elucidating cellular and molecular mechanisms of steroid hormone-mediated regulation of reproductive target tissues and of tumors that develop in these tissues, especially breast cancer.[10]

Katzenellenbogen has published more than 330 research articles, contributed 30 book chapters, and co-edited a book on hormone-dependent cancers.[11] She has trained more than 90 graduate students and postdoctoral scientists and has overseen numerous undergraduates in their biomedical research. For her activities in mentoring, she was recognized with the Mentor Award from Women in Endocrinology in 2011.[12] She is also the recipient of numerous other awards, honors, and special fellowships from governmental, private, and academic institutions. These include the MERIT Award from the National Cancer Institute of the NIH (1991-1999), the Brinker Award for Scientific Distinction from the Susan G. Komen for the Cure Breast Cancer Foundation (2009), the Jill Rose Award from The Breast Cancer Research Foundation (1998),[13] the Ernst Oppenheimer Award (1984),[14] and the Roy O. Greep Lecture Award from The Endocrine Society (2006).[15] In 2016, she shared the Fred Conrad Koch Lifetime Achievement Award from The Endocrine Society with Dr. John Katzenellenbogen.[16] She was elected a Fellow of the American Academy of Arts and Sciences (1993),[17] and she received a Distinguished Alumni Award from The City University of New York in 2002[18] and an Honorary Degree from the University of Milan, Italy (2007).

She has served on many committees and review panels, journal editorial boards, and as President of The Endocrine Society (2000–2001).[19] She served full terms on the NIH Endocrinology (1979-1983) and Biochemical Endocrinology Study Sections (1995-1999), was Vice Chair of the American Cancer Society Review Panel on Biochemistry and Endocrinology (1992-1993), and was Chair of the NIH, NIDDK Board of Scientific Counselors (1988-1989). She served as a member of the External Advisory Committee for the NIH Nuclear Receptor Signaling Atlas (2002-2012) and on Review Panels for Komen for the Cure, the DOD Breast Cancer Program, and on NIH graduate and postdoctoral fellowship review committees. She co-chaired the Hormone Action Gordon Research Conference in 1988[20] and the Keystone Symposium on The Nuclear Receptor Superfamily in 2002.[21]

Research

Katzenellenbogen has clarified structure-function relationships and actions of estrogen receptors alpha and beta,[22] [23] [24] [25] [26] and demonstrated that estrogens have a broad spectrum of effects on gene networks and pathways in breast cancer and other cells.[27] [28] This research has contributed to understanding of the molecular basis for the action of selective estrogen receptor modulators (SERMs) such as tamoxifen in target cells,[29] [30] [31] [32] and for the development of anti-hormonal treatments used in breast cancer treatment and prevention.[33] [34] Her laboratory demonstrated that estrogen receptors regulate and function along with multiple cell signaling pathways involving kinase cascades and growth factors,[35] [36] [37] and that these inputs converge at the level of chromatin to regulate gene expression and cell signaling.[26] This work presaged the current active interest in both the non-genomic actions of estrogens[36] [38] [39] and the cross-talk between nuclear receptors and other cell signaling pathways and their roles in endocrine resistance. Her laboratory has also identified factors associated with aggressiveness and early time to cancer recurrence[40] [41] [42] [43] [44] [45] [46] and their regulation in different subtypes of breast cancer.[47] She has also characterized the activities of estrogens in menopausal hormone replacement therapies and diverse ligands for estrogen receptors,[36] [48] including environmental estrogens,[49] phytoestrogens such as genistein,[23] [50] [51] and estrogen receptor subtype-selective ligands in various estrogen target tissues.[52] [53] [54] [55]

External links

Notes and References

  1. Web site: Endocrine Society Announces 2016 Laureate Award Winners Endocrine Society. www.endocrine.org. en. 2017-12-23.
  2. Web site: Breast Cancer Awards & Recognition Susan G. Komen®. ww5.komen.org. 2017-12-23.
  3. 10.1016/0022-1910(71)90016-3 . General esterases of silkmoth moulting fluid: Preliminary characterization . Journal of Insect Physiology . 17 . 6 . 1139–43 . 1971 . Katzenellenbogen . Benita S . Kafatos . Fotis C .
  4. 10.1016/0022-1910(71)90123-5 . Proteinases of silkmoth moulting fluid: Physical and catalytic properties . Journal of Insect Physiology . 17 . 4 . 775–800 . 1971 . Katzenellenbogen . Benita S . Kafatos . Fotis C .
  5. 4335193 . 1972 . Katzenellenbogen . B. S . Estrogen action in vitro. Induction of the synthesis of a specific uterine protein . The Journal of Biological Chemistry . 247 . 4 . 1299–305 . Gorski . J . 10.1016/S0021-9258(19)45646-9 . free .
  6. 10.1210/endo-92-1-125 . 4681918 . Estrone Interaction with the Rat Uterus: In Vitro Response and Nuclear Uptake1 . Endocrinology . 92 . 1 . 125–34 . 1973 . Ruh . Thomas S . Katzenellenbogen . Benita S . Katzenellenbogen . John A . Gorski . JAC .
  7. Web site: People Carl R. Woese Institute for Genomic Biology. www.igb.illinois.edu. en. 2017-12-22.
  8. Web site: Understanding the Nature of Cancer, One Cell at a Time, News, Beckman Institute, University of Illinois. Technology. Beckman Institute for Advanced Science and. beckman.illinois.edu. en. 2017-12-22.
  9. 10.1371/journal.pgen.0030087 . 17542648 . 1885282 . Whole-Genome Cartography of Estrogen Receptor α Binding Sites . PLOS Genetics . 3 . 6 . e87 . 2007 . Lin . Chin-Yo . Vega . Vinsensius B . Thomsen . Jane S . Zhang . Tao . Kong . Say Li . Xie . Min . Chiu . Kuo Ping . Lipovich . Leonard . Barnett . Daniel H . Stossi . Fabio . Yeo . Ailing . George . Joshy . Kuznetsov . Vladimir A . Lee . Yew Kok . Charn . Tze Howe . Palanisamy . Nallasivam . Miller . Lance D . Cheung . Edwin . Katzenellenbogen . Benita S . Ruan . Yijun . Bourque . Guillaume . Wei . Chia-Lin . Liu . Edison T . free .
  10. News: Meet the 2016 Laureate Award Winners: Benita Katzenellenbogen, PhD, and John Katzenellenbogen, PhD - Endocrine News. 2016-01-25. Endocrine News. 2017-12-23. en-US.
  11. Book: Hormone-Dependent Cancer. Pasqualini. Jorge. Katzenellenbogen. Benita. Taylor & Francis. 1996. 9780824796976.
  12. Web site: Past Mentor Award Recipients Women in Endocrinology. www.women-in-endo.org. en-US. 2017-12-22.
  13. Web site: BCRF :: Jill Rose Award. rayogram. legacy.bcrfcure.org. en. 2017-12-22.
  14. Web site: Ernst Oppenheimer Award Endocrine Society. www.endocrine.org. en. 2017-12-22.
  15. Web site: Roy O. Greep Award for Outstanding Research Endocrine Society. www.endocrine.org. en. 2017-12-23.
  16. Web site: Noteworthy - American Academy of Arts & Sciences. 2017-12-22. https://web.archive.org/web/20171223102025/https://www.amacad.org/content/publications/pubContent.aspx?d=22294. 2017-12-23. dead.
  17. Web site: American Academy of Arts and Sciences Fellows Listing. January 1, 2017. amacad.org. 316. December 22, 2017.
  18. Web site: News Bureau ILLINOIS. Illinois. Inside. news.illinois.edu. en-US. 2017-12-22.
  19. Web site: Hall of Presidents Endocrine Society. www.endocrine.org. en. 2017-12-22.
  20. Web site: Mechanisms of Hormone Action - Gordon Research Conferences. www.grc.org. en. 2017-12-22.
  21. Web site: Keystone Symposia Scientific Conferences on Biomedical and Life Science Topics. Keystone Symposia. en. 2017-12-22.
  22. 10.1210/en.2003-1682 . 15033914 . Transcriptional Profiling of Estrogen-Regulated Gene Expression via Estrogen Receptor (ER) α or ERβ in Human Osteosarcoma Cells: Distinct and Common Target Genes for These Receptors . Endocrinology . 145 . 7 . 3473–86 . 2004 . Stossi . Fabio . Barnett . Daniel H . Frasor . Jonna . Komm . Barry . Lyttle . C. Richard . Katzenellenbogen . Benita S . free .
  23. 10.1210/me.2007-0356 . 18258689 . 2366177 . Estrogen Receptors α and β as Determinants of Gene Expression: Influence of Ligand, Dose, and Chromatin Binding . Molecular Endocrinology . 22 . 5 . 1032–43 . 2008 . Chang . Edmund C . Charn . Tze Howe . Park . Sung-Hee . Helferich . William G . Komm . Barry . Katzenellenbogen . John A . Katzenellenbogen . Benita S .
  24. 10.1128/MCB.01476-08 . 19188451 . 2655624 . Estrogen Receptor Alpha Represses Transcription of Early Target Genes via p300 and CtBP1 . Molecular and Cellular Biology . 29 . 7 . 1749–59 . 2009 . Stossi . F . Madak-Erdogan . Z . Katzenellenbogen . B. S .
  25. 8226955 . 1993 . Wrenn . C. K . Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast . The Journal of Biological Chemistry . 268 . 32 . 24089–98 . Katzenellenbogen . B. S . 10.1016/S0021-9258(20)80497-9 . free .
  26. Madak-Erdogan. Z. Charn. T.-H. Jiang. Y. Liu. E. T. Katzenellenbogen. J. A. Katzenellenbogen. B. S. 2014. Integrative genomics of gene and metabolic regulation by estrogen receptors alpha and beta, and their coregulators. Molecular Systems Biology. 9. 676. 10.1038/msb.2013.28. 3964312. 23774759.
  27. 10.1210/en.2003-0567 . 12959972 . Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype . Endocrinology . 144 . 10 . 4562–74 . 2003 . Frasor . Jonna . Danes . Jeanne M . Komm . Barry . Chang . Ken C. N . Lyttle . C. Richard . Katzenellenbogen . Benita S . free .
  28. 10.1210/en.2006-0563 . 16809442 . Impact of Estrogen Receptor β on Gene Networks Regulated by Estrogen Receptor α in Breast Cancer Cells . Endocrinology . 147 . 10 . 4831–42 . 2006 . Chang . Edmund C . Frasor . Jonna . Komm . Barry . Katzenellenbogen . Benita S . free .
  29. 9122238 . 20131 . 1997 . Montano . M. M . The quinone reductase gene: A unique estrogen receptor-regulated gene that is activated by antiestrogens . Proceedings of the National Academy of Sciences of the United States of America . 94 . 6 . 2581–6 . Katzenellenbogen . B. S . 1997PNAS...94.2581M . 10.1073/pnas.94.6.2581 . free .
  30. 10359819 . 22022 . 1999 . Montano . M. M . An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens . Proceedings of the National Academy of Sciences of the United States of America . 96 . 12 . 6947–52 . Ekena . K . Delage-Mourroux . R . Chang . W . Martini . P . Katzenellenbogen . B. S . 1999PNAS...96.6947M . 10.1073/pnas.96.12.6947 . free .
  31. 14973112 . Selective estrogen receptor modulators: Discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells . 2004 . Frasor . J . Cancer Research . 64 . 4 . 1522–33 . Stossi . F . Danes . J. M . Komm . B . Lyttle . C. R . Katzenellenbogen . B. S . 10.1158/0008-5472.CAN-03-3326 . 35304 .
  32. 10.1210/en.2011-1100 . 21862609 . 3199013 . Repressor of Estrogen Receptor Activity (REA) is Essential for Mammary Gland Morphogenesis and Functional Activities: Studies in Conditional Knockout Mice . Endocrinology . 152 . 11 . 4336–49 . 2011 . Park . Sunghee . Zhao . Yuechao . Yoon . Sangyeon . Xu . Jianming . Liao . Lan . Lydon . John . Demayo . Franco . O'Malley . Bert W . Katzenellenbogen . Benita S .
  33. 10.1053/j.seminoncol.2004.01.004 . 15052541 . Therapeutic targeting in the estrogen receptor hormonal pathway . Seminars in Oncology . 31 . 1 Suppl 3 . 28–38 . 2004 . Katzenellenbogen . Benita S . Frasor . Jonna .
  34. 10.1016/j.ctrv.2016.08.008 . 27643748 . Endocrine treatment in breast cancer: Cure, resistance and beyond . Cancer Treatment Reviews . 50 . 68–81 . 2016 . Tryfonidis . Konstantinos . Zardavas . Dimitrios . Katzenellenbogen . Benita S . Piccart . Martine .
  35. 10.1210/endo-126-2-891 . 2404751 . Multihormonal Regulation of the Progesterone Receptor in MCF-7 Human Breast Cancer Cells: Interrelationships among Insulin/Insulin-Like Growth Factor-I, Serum, and Estrogen . Endocrinology . 126 . 2 . 891–8 . 1990 . Katzenellenbogen . Benita S . Jane Norman . Mary . free .
  36. 10.1126/scisignal.aad8170 . 27221711 . 4896643 . Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues . Science Signaling . 9 . 429 . ra53 . 2016 . Madak-Erdogan . Z . Kim . S. H . Gong . P . Zhao . Y. C . Zhang . H . Chambliss . K. L . Carlson . K. E . Mayne . C. G . Shaul . P. W . Korach . K. S . Katzenellenbogen . J. A . Katzenellenbogen . B. S .
  37. 10.1128/MCB.00821-10 . 20956553 . 3019850 . Genomic Collaboration of Estrogen Receptor   and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs . Molecular and Cellular Biology . 31 . 1 . 226–36 . 2010 . Madak-Erdogan . Z . Lupien . M . Stossi . F . Brown . M . Katzenellenbogen . B. S .
  38. 10.1210/me.2005-0186 . 16306086 . Estrogen Dendrimer Conjugates that Preferentially Activate Extranuclear, Nongenomic Versus Genomic Pathways of Estrogen Action . Molecular Endocrinology . 20 . 3 . 491–502 . 2006 . Harrington . William R . Kim . Sung Hoon . Funk . Cory C . Madak-Erdogan . Zeynep . Schiff . Rachel . Katzenellenbogen . John A . Katzenellenbogen . Benita S . free .
  39. 10.1210/me.2008-0059 . 18617595 . 2631368 . Nuclear and Extranuclear Pathway Inputs in the Regulation of Global Gene Expression by Estrogen Receptors . Molecular Endocrinology . 22 . 9 . 2116–27 . 2008 . Madak-Erdogan . Zeynep . Kieser . Karen J . Kim . Sung Hoon . Komm . Barry . Katzenellenbogen . John A . Katzenellenbogen . Benita S .
  40. 10.1186/bcr2913 . 21707964 . 3218959 . Reversal of endocrine resistance in breast cancer: Interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis . Breast Cancer Research . 13 . 3 . R70 . 2011 . Bergamaschi . Anna . Christensen . Barbara L . Katzenellenbogen . Benita S . free .
  41. 10.1158/1541-7786.MCR-13-0588 . 24505128 . 4020978 . Novel Roles for ERK5 and Cofilin as Critical Mediators Linking ERα-Driven Transcription, Actin Reorganization, and Invasiveness in Breast Cancer . Molecular Cancer Research . 12 . 5 . 714–27 . 2014 . Madak-Erdogan . Zeynep . Ventrella . Rosa . Petry . Luke . Katzenellenbogen . Benita S .
  42. 10.1186/s13058-014-0436-4 . 25213081 . 4303117 . The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells . Breast Cancer Research . 16 . 5 . 436 . 2014 . Bergamaschi . Anna . Madak-Erdogan . Zeynep . Kim . Yu Jin . Choi . Yoon-La . Lu . Hailing . Katzenellenbogen . Benita S . free .
  43. 10.1210/mend.10.11.8923465 . 8923465 . Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein . Molecular Endocrinology . 10 . 11 . 1388–98 . 1996 . Weis . K E . Ekena . K . Thomas . J A . Lazennec . G . Katzenellenbogen . B S . free .
  44. 10.1210/mend.11.9.9983 . 9259327 . Mechanistic Aspects of Estrogen Receptor Activation Probed with Constitutively Active Estrogen Receptors: Correlations with DNA and Coregulator Interactions and Receptor Conformational Changes . Molecular Endocrinology . 11 . 9 . 1375–86 . 1997 . Lazennec . Gwendal . Ediger . Tracy R . Petz . Larry N . Nardulli . Ann M . Katzenellenbogen . Benita S . free .
  45. 10.7554/eLife.12792 . 26836308 . 4821807 . Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation . eLife . 5 . 2016 . Fanning . Sean W . Mayne . Christopher G . Dharmarajan . Venkatasubramanian . Carlson . Kathryn E . Martin . Teresa A . Novick . Scott J . Toy . Weiyi . Green . Bradley . Panchamukhi . Srinivas . Katzenellenbogen . Benita S . Tajkhorshid . Emad . Griffin . Patrick R . Shen . Yang . Chandarlapaty . Sarat . Katzenellenbogen . John A . Greene . Geoffrey L . free .
  46. 10.1158/0008-5472.CAN-17-1265 . 28904064 . 5645250 . Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors . Cancer Research . 77 . 20 . 5602–5613 . 2017 . Zhao . Yuechao . Laws . Mary J . Guillen . Valeria Sanabria . Ziegler . Yvonne . Min . Jian . Sharma . Abhishek . Kim . Sung Hoon . Chu . David . Park . Ben Ho . Oesterreich . Steffi . Mao . Chengjian . Shapiro . David J . Nettles . Kendall W . Katzenellenbogen . John A . Katzenellenbogen . Benita S .
  47. Bergamaschi. Anna. Frasor. Jonna. Borgen. Kristina. Stanculescu. Adina. Johnson. Patricia. Rowland. Kendrith. Wiley. Elizabeth L. Katzenellenbogen. Benita S. 2012. 14-3-3ζ as a predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers. Breast Cancer Research and Treatment. 137. 3. 689–96. 10.1007/s10549-012-2390-0. 3632437. 23271328.
  48. 10.1126/scitranslmed.3010626 . 25609169 . 4790140 . Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis . Science Translational Medicine . 7 . 271 . 271ra9 . 2015 . Zhao . Y . Gong . P . Chen . Y . Nwachukwu . J. C . Srinivasan . S . Ko . C . Bagchi . M. K . Taylor . R. N . Korach . K. S . Nettles . K. W . Katzenellenbogen . J. A . Katzenellenbogen . B. S .
  49. 10.1210/endo-105-1-33 . 446414 . Zearalenones: Characterization of the Estrogenic Potencies and Receptor Interactions of a Series of Fungal β-Resorcylic Acid Lactones . Endocrinology . 105 . 1 . 33–40 . 1979 . Katzenellenbogen . Benita S . Katzenellenbogen . John A . Mordecai . David .
  50. Gong. Ping. Madak-Erdogan. Zeynep. Li. Jilong. Cheng. Jianlin. Greenlief. C. Michael. Helferich. William. Katzenellenbogen. John A.. Katzenellenbogen. Benita S.. 2014. Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nuclear Receptor Signaling. 12. e001. 10.1621/nrs.12001. 1550-7629. 4193135. 25363786.
  51. 10.1096/fj.13-234617 . 23882126 . 3804744 . Mechanisms enforcing the estrogen receptor   selectivity of botanical estrogens . The FASEB Journal . 27 . 11 . 4406–18 . 2013 . Jiang . Y . Gong . P . Madak-Erdogan . Z . Martin . T . Jeyakumar . M . Carlson . K . Khan . I . Smillie . T. J . Chittiboyina . A. G . Rotte . S. C. K . Helferich . W. G . Katzenellenbogen . J. A . Katzenellenbogen . B. S . free .
  52. 10.1021/jm010254a . 11708925 . Estrogen Receptor-β Potency-Selective Ligands:  Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues . Journal of Medicinal Chemistry . 44 . 24 . 4230–51 . 2001 . Meyers . Marvin J . Sun . Jun . Carlson . Kathryn E . Marriner . Gwendolyn A . Katzenellenbogen . Benita S . Katzenellenbogen . John A .
  53. 10.1210/endo.143.3.8704 . 11861516 . Antagonists Selective for Estrogen Receptor α . Endocrinology . 143 . 3 . 941–7 . 2002 . Sun . Jun . Huang . Ying R . Harrington . William R . Sheng . Shubin . Katzenellenbogen . John A . Katzenellenbogen . Benita S . free .
  54. Harris. Heather A. Katzenellenbogen. John A. Katzenellenbogen. Benita S. 2002. Characterization of the Biological Roles of the Estrogen Receptors, ERα and ERβ, in Estrogen Target Tissues in Vivo through the Use of an ERα-Selective Ligand. Endocrinology. 143. 11. 4172–7. 10.1210/en.2002-220403. 12399409. free.
  55. 10.1210/me.2002-0341 . 12554752 . Molecular Basis for the Subtype Discrimination of the Estrogen Receptor-β-Selective Ligand, Diarylpropionitrile . Molecular Endocrinology . 17 . 2 . 247–58 . 2003 . Sun . Jun . Baudry . Jerome . Katzenellenbogen . John A . Katzenellenbogen . Benita S . free .

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