Olmesartan/hydrochlorothiazide explained

Type:combo
Component1:Olmesartan
Class1:Angiotensin II antagonist
Component2:Hydrochlorothiazide
Class2:Thiazide diuretic
Tradename:Benicar HCT, Benitec H, others
Dailymedid:Olmesartan hydrochlorothiazide
Routes Of Administration:By mouth
Atc Prefix:C09
Atc Suffix:DA08
Legal Us:Rx-only
Legal Us Comment:[1]
Cas Number:760190-74-7
Kegg:D10284

Olmesartan/hydrochlorothiazide, sold under the brand name Benicar HCT among others, is a fixed-dose combination medication used to treat high blood pressure. It is a combination of olmesartan medoxomil, an angiotensin II receptor blocker and hydrochlorothiazide, a diuretic. It may be used if olmesartan is not sufficient to manage blood pressure. It is taken by mouth.[2]

Common side effects include nausea, dizziness, and upper respiratory tract infections.[1] Serious side effects may include kidney problems, allergic reactions, electrolyte problems and low blood pressure.[1] Use in pregnancy is not recommended.[1] Olmesartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by increasing the loss of sodium by the kidneys.

No generic version is available in the United States as of 2017.[3] In 2020, it was the 281st most commonly prescribed medication in the United States, with more than 1million prescriptions.[4] [5]

Notes and References

  1. Web site: Benicar HCT- olmesartan medoxomil-hydrochlorothiazide tablet, film coated . DailyMed . 7 September 2022 . 3 January 2023.
  2. Book: British national formulary : BNF 76. 2018. Pharmaceutical Press. 9780857113382. 177–178. 76.
  3. Book: Bope ET, Kellerman RD . Conn's Current Therapy 2017 E-Book . 2016 . Elsevier Health Sciences . 9780323443357 . 124 .
  4. Web site: The Top 300 of 2020 . ClinCalc . 7 October 2022.
  5. Web site: Hydrochlorothiazide; Olmesartan - Drug Usage Statistics . ClinCalc . 7 October 2022.