| Honorific-Prefix: | Most Reverend |
| Benedetto de Sanctis | |
| Bishop of Alessano | |
| Church: | Catholic Church |
| Diocese: | Diocese of Alessano |
| Term: | 1540–1542 |
| Predecessor: | Francesco Antonio Balduini |
| Successor: | Evangelista Cittadini |
| Death Date: | 1542 |
| Death Place: | Alessano, Italy |
Benedetto de Sanctis (died 1542) was a Roman Catholic prelate who served as Bishop of Alessano (1540–1542).[1]
On 15 March 1540, Benedetto de Sanctis was appointed during the papacy of Pope Paul III as Bishop of Alessano. He served as Bishop of Alessano until his death in 1542.