Bayer Explained

Bayer AG
Type:Public
Founder:Friedrich Bayer
Foundation:[1]
Location:Leverkusen, North Rhine-Westphalia, Germany
Area Served:Worldwide
Revenue: (2023)[2]
Operating Income: €7.01 billion (2022)
Net Income: €4.15 billion (2022)
Assets: €124.9 billion (2022)
Equity: €38.93 billion (2022)
Num Employees:101,369 (2022)
Industry:

Bayer AG (English:, commonly pronounced ;[3] pronounced as /de/) is a German multinational pharmaceutical and biotechnology company and is one of the largest pharmaceutical companies and biomedical companies in the world. Headquartered in Leverkusen, Bayer's areas of business include: pharmaceuticals, consumer healthcare products, agricultural chemicals, seeds and biotechnology products. The company is a component of the EURO STOXX 50 stock market index.[4]

Bayer was founded in 1863 in Barmen as a partnership between dye salesman Friedrich Bayer (1825–1880) and dyer Friedrich Weskott (1821–1876). The company was established as a dyestuffs producer, but the versatility of aniline chemistry led Bayer to expand its business into other areas. In 1899, Bayer launched the compound acetylsalicylic acid under the trademarked name Aspirin. Aspirin is on the World Health Organization's List of Essential Medicines.[5] In 2021, it was the 34th most commonly prescribed medication in the United States, with more than 17million prescriptions.[6] [7]

In 1904, Bayer received a trademark for the "Bayer Cross" logo, which was subsequently stamped onto each aspirin tablet, creating an iconic product that is still sold by Bayer. Other commonly known products initially commercialized by Bayer include heroin, phenobarbital, polyurethanes, and polycarbonates.

In 1925, Bayer merged with five other German companies to form IG Farben, creating the world's largest chemical and pharmaceutical company. The first sulfonamide and the first systemically active antibacterial drug, forerunner of antibiotics,[8] Prontosil, was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories. Following World War II, the Allied Control Council seized IG Farben's assets[9] because of its role in the Nazi war effort and involvement in the Holocaust, including using slave labour from concentration camps and humans for dangerous medical testing, and production of Zyklon B, a chemical used in gas chambers.[10] In 1951, IG Farben was split into its constituent companies, and Bayer was reincorporated as Farbenfabriken Bayer AG. After the war, Bayer re-hired several former nazis to high-level positions, including convicted nazi warcriminals found guilty at the IG Farben Trial like Fritz ter Meer.[11] [12] Bayer played a key role in the in post-war West Germany, quickly regaining its position as one of the world's largest chemical and pharmaceutical corporations.

In 2016, Bayer merged with the American multinational Monsanto in what was the biggest acquisition by a German company to date.[13] However, owing to the massive financial and reputational blows caused by ongoing litigation concerning Monsanto's herbicide Roundup, the deal is considered one of the worst corporate mergers in history.[14] [15] [16]

Bayer owns the Bundesliga football club Bayer 04 Leverkusen.

Early history

Foundation

Bayer AG was founded as a dyestuffs factory in 1863 in Barmen (later part of Wuppertal), Germany, by Friedrich Bayer and his partner, Johann Friedrich Weskott, a master dyer. Bayer was responsible for the commercial tasks. Fuchsine and aniline became the company's most important products.[17]

The headquarters and most production facilities moved from Barmen to a larger area in Elberfeld in 1866. Friedrich Bayer (1851–1920), the son of the company's founder, was a chemist and joined the company in 1873. After the death of his father in 1880, the company became a joint-stock company, Farbenfabriken vorm. Friedr. Bayer & Co, also known as Elberfelder Farbenfabriken.[18]

A further expansion in Elberfeld was impossible, so the company moved to the village Wiesdorf at Rhein and settled in the area of the alizarin producer Leverkus and Sons. A new city, Leverkusen, was founded there in 1930 and became home to Bayer AG's headquarters. The company's corporate logo, the Bayer cross, was introduced in 1904, consisting of the word BAYER written vertically and horizontally, sharing the Y and enclosed in a circle. An illuminated version of the logo is a landmark in Leverkusen.[19]

Aspirin

Bayer's first major product was acetylsalicylic acid—first described by French chemist Charles Frederic Gerhardt in 1853—a modification of salicylic acid or salicin, a folk remedy found in the bark of the willow plant. By 1899, Bayer's trademark Aspirin was registered worldwide for Bayer's brand of acetylsalicylic acid, but it lost its trademark status in the United States, France and the United Kingdom after the confiscation of Bayer's US assets and trademarks during World War I by the United States, and because of the subsequent widespread usage of the word.

The term aspirin continued to be used in the US, UK and France for all brands of the drug,[20] but it is still a registered trademark of Bayer in over 80 countries, including Canada, Mexico, Germany and Switzerland. As of 2011, approximately 40,000 tons of aspirin were produced each year and 10–20 billion tablets consumed in the United States alone for prevention of cardiovascular events.[21] It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[22]

There is an unresolved controversy over the roles played by Bayer scientists in the development of aspirin. Arthur Eichengrün, a Bayer chemist, said he was the first to discover an aspirin formulation that did not have the unpleasant side effects of nausea and gastric pain. He also said he had invented the name aspirin and was the first person to use the new formulation to test its safety and efficacy. Bayer contends that aspirin was discovered by Felix Hoffmann to help his father, who had arthritis.[23] Various sources support the conflicting claims.[24] [25] Most mainstream historians attribute the invention of aspirin to Hoffmann and/or Eichengrün.[26] [25]

Heroin

Heroin (diacetylmorphine), now illegal as an addictive drug, was introduced as a non-addictive substitute for morphine,[27] and trademarked and marketed by Bayer from 1898 to 1910 as a cough suppressant and over-the-counter treatment for other common ailments, including pneumonia and tuberculosis. While Bayer scientists were not the first to make heroin, the company did lead the way in commercializing it.[28] Heroin was a Bayer trademark until after World War I.[29] Bayer's director of pharmacology did not want the drug to have "too complicated a name" so Bayer settled on heroisch, the German word for heroic.[30]

Phenobarbital

In 1903, Bayer licensed the patent for the hypnotic drug diethylbarbituric acid from its inventors Emil Fischer and Joseph von Mering. It was marketed under the trade name Veronal as a sleep aid beginning in 1904. Systematic investigations of the effect of structural changes on potency and duration of action at Bayer led to the discovery of phenobarbital in 1911 and the discovery of its potent anti-epileptic activity in 1912. Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014 it remains on the World Health Organization's list of essential medications.[31] [32]

World War I

During World War I (1914–1918), Bayer's assets, including the rights to its name and trademarks, were confiscated in the United States, Canada and several other countries.[33] In the United States and Canada, Bayer's assets and trademarks, including the well-known Bayer cross, were acquired by Sterling Drug, a predecessor of Sterling Winthrop and were not reclaimed until 1994.

Throughout the war, Bayer was involved in production and development of various chemical weapons. In 1914, Bayer manufactured dianisidine chlorosulfate for use in 105 mm artillery shell, intended as a lung irritant against British forces.[34] [35]

In 1916, Bayer scientists discovered suramin, an anti-parasite drug that is still sold by Bayer under the brand name Germanin. The formula of suramin was kept secret by Bayer for commercial reasons, but it was elucidated and published in 1924 by Ernest Fourneau and his team at the Pasteur Institute.[36] It is on the World Health Organization's List of Essential Medicines.[37]

IG Farben

In 1925, Bayer became part of IG Farben, a German conglomerate formed from the merger of six chemical companies: BASF, Bayer, Hoechst (including Cassella and Chemische Fabrik Kalle), Agfa, Chemische Fabrik Griesheim-Elektron, and Chemische Fabrik vorm. Weiler Ter Meer. In the 1930s, Gerhard Domagk, director of Bayer's Institute of Pathology and Bacteriology, working with chemists Fritz Mietzsch and Joseph Klarer, discovered prontosil, the first commercially available antibacterial drug. The discovery and development of this first sulfonamide drug opened a new era in medicine. Domagk won the Nobel Prize in Physiology or Medicine in 1939 "for the discovery of the antibacterial effects of prontosil".[38] He was forced by the Nazi Party to relinquish the reward; German citizens had been forbidden from accepting Nobel prizes since the Nobel committee had awarded the 1935 Nobel Peace Prize to a German pacifist, Carl von Ossietzky.[39]

World War II and the Holocaust

IG Farben, Bayer's parent company, used slave labour in factories it built in Nazi concentration camps, most notably in the Monowitz concentration camp (known as Auschwitz III), part of the Auschwitz camp complex in German-occupied Poland.[40] By 1943, almost half of IG Farben's 330,000-strong workforce consisted of slave labour or conscripts, including 30,000 Auschwitz prisoners.

Helmuth Vetter, an Auschwitz camp physician, SS captain and employee of the Bayer group within IG Farben conducted medical experiments on inmates at Auschwitz and at the Mauthausen concentration camp.[41] In one study of an anaesthetic, the company paid RM 170 per person for the use of 150 female inmates of Auschwitz.[42] [43] A Bayer employee wrote to Rudolf Höss, the Auschwitz commandant: "The transport of 150 women arrived in good condition. However, we were unable to obtain conclusive results because they died during the experiments. We would kindly request that you send us another group of women to the same number and at the same price."[44]

After the war, the Allied Control Council seized IG Farben for "knowingly and prominently ... building up and maintaining German war potential".[9] It was split into its six constituent companies in 1951, then split again into three: BASF, Bayer and Hoechst.[45] Bayer was at that point known as Farbenfabriken Bayer AG; it changed its name to Bayer AG in 1972. After the war, some employees of Bayer appeared in the IG Farben Trial, one of the Nuremberg Subsequent Tribunals under US jurisdiction. Among them was Fritz ter Meer, who helped to plan the Monowitz camp (Auschwitz III) and IG Farben's Buna Werke factory at Auschwitz, where medical experimentation had been conducted and where 25,000 forced laborers were deployed. Ter Meer was sentenced to seven years, but was released in 1950. Despite being a convicted nazi war criminal, Ter Meer was elected as chairman of Bayer AG's supervisory board in 1956, a position he retained until 1964.[46]

Helge Wehmeier, then CEO of Bayer, offered a public apology in 1995 to Elie Wiesel for the company's actions during World War II (1939–1945) and the Holocaust.[47]

Products

Overview

In 1953, Bayer brought the first neuroleptic (chlorpromazine) onto the German market.[48] In the 1960s, Bayerintroduced a pregnancy test, Primodos, that consisted of two pills that contained norethisterone (as acetate) and ethinylestradiol. It detected pregnancy by inducing menstruation in women who were not pregnant; the presence or absence of menstrual bleeding was then used to determine whether the user was pregnant. The test became the subject of controversy when it was blamed for birth defects, and it was withdrawn from the market in the mid-1970s. Litigation in the 1980s ended inconclusively. A review of the matter by the Medicines and Healthcare products Regulatory Agency in 2014 assessed the studies performed to date and found the evidence for adverse effects to be inconclusive.[49]

In 1978, Bayer purchased Miles Laboratories and its subsidiaries Miles Canada and Cutter Laboratories, acquiring along with them a variety of product lines including Alka-Seltzer, Flintstones vitamins and One-A-Day vitamins, and Cutter insect repellent.[50]

Along with the purchase of Cutter, Bayer acquired Cutter's Factor VIII business. Factor VIII, a clotting agent used to treat hemophilia, was produced, at the time, by processing donated blood. In the early days of the AIDS epidemic, people with hemophilia were found to have higher rates of AIDS, and by 1983 the CDC had identified contaminated blood products as a source of infection. According to the New York Times, this was "one of the worst drug-related medical disasters in history". Companies, including Bayer, developed new ways to treat donated blood with heat to decontaminate it, and these new products were introduced early in 1984. In 1997, Bayer and the other three makers of such blood products agreed to pay $660 million to settle cases on behalf of more than 6,000 hemophiliacs infected in United States. But in 2003, documents emerged showing that Cutter had continued to sell unheated blood products in markets outside the US until 1985, including in Malaysia, Singapore, Indonesia, Japan and Argentina, to offload a product they were unable to sell in Europe and the US; they also continued manufacturing the unheated product for several months. Bayer said it did this because some countries were doubtful about the efficacy of the new product.[51]

Bayer has been involved in other controversies regarding its drug products. In the late 1990s it introduced a statin drug, Baycol (cerivastatin), but after 52 deaths were attributed to it, Bayer discontinued it in 2001. The side effect was rhabdomyolysis, causing kidney failure, which occurred with a tenfold greater frequency in patients treated with Baycol in comparison to those prescribed alternate medications of the statin class.[52] Trasylol (aprotinin), used to control bleeding during major surgery, was withdrawn from the market worldwide in 2007 when reports of increased mortality emerged; it was later re-introduced in Europe but not in the US.[53]

Top-selling pharmaceutical products

In 2014, pharmaceutical products contributed €12.05 billion of Bayer's €40.15 billion in gross revenue.[54] In 2019, identified "key growth" products were Xarelto (rivaroxaban), Eylea (aflibercept), Stivarga (regorafenib), Xofigo (radium-223), and Adempas (riociguat).[55] Top-selling products as of 2014 included:

Agricultural

Bayer produces various fungicides, herbicides, insecticides, and some crop varieties.[76]

Acquisitions

Overview

In 1994, Bayer AG purchased Sterling Winthrop's over-the-counter (OTC) drug business from SmithKline Beecham and merged it with Miles Laboratories, thereby reclaiming the U.S. and Canadian trademark rights to "Bayer" and the Bayer cross, as well as the ownership of the Aspirin trademark in Canada.[94]

In 2004, Bayer HealthCare acquired the over-the-counter pharmaceutical division of Roche.[95] In March 2008, Bayer HealthCare announced an agreement to acquire the portfolio and OTC division of privately owned Sagmel, Inc., a US-based company that markets OTC medications in most of the Commonwealth of Independent States countries such as Russia, Ukraine, Kazakhstan, Belarus, and others.[96] [97]

On 28 August 2008, an explosion occurred at the Bayer CropScience facility at Institute, West Virginia, United States. A runaway reaction ruptured a tank and the resulting explosion killed two employees.[98] The ruptured tank was close to a methyl isocyanate tank which was undamaged by the explosion.[99]

Acquisition of Schering

In March 2006, Merck KGaA announced a €14.6bn bid for Schering AG, founded in 1851. By 2006, Schering had annual gross revenue of around €5 billion[100] and employed about 26,000 people in 140 subsidiaries worldwide. Bayer responded with a white knight bid and in July acquired the majority of shares of Schering for €14.6bn,[101] and in 2007, Bayer took over Schering AG and formed Bayer Schering Pharma. The acquisition of Schering was the largest take-over in Bayer's history,[102] and as of 2015, was one of the ten biggest pharma mergers of all time.[103]

Other acquisitions

In November 2010, Bayer AG signed an agreement to buy Auckland-based animal health company Bomac Group.[104] Bayer partnered on the development of the radiotherapeutic Xofigo with Algeta, and in 2014, moved to acquire the company for about $2.9 billion.[105] In 2014, Bayer agreed to buy Merck's consumer health business for $14.2 billion which would provide Bayer control with brands such as Claritin, Coppertone and Dr. Scholl's. Bayer would attain second place globally in nonprescription drugs.[106] In June 2015, Bayer agreed to sell its diabetic care business to Panasonic Healthcare Holdings for a fee of $1.02 billion.[107]

In August 2019, the business acquired the ≈60% of BlueRock Therapeutics it didn't already own for up to $600 million.[108] [109]

In August 2020, Bayer announced it had acquired KaNDy Therapeutics Ltd, helping to boost its female healthcare business, for $425 million.[110] [111] [112] In October, Bayer agreed to acquire Asklepios BioPharmaceuticals for $2 billion upfront.[113]

In June 2021, the company announced it acquire Noria Therapeutics Inc. and PSMA Therapeutics Inc. gaining rights to a number of cancer-based investigational compounds based on actinium-225.[114]

Spin off of Covestro

In September 2015, Bayer spun out its $12.3 billion materials science division into a separate, publicly traded company called Covestro in which it retained about a 70% interest.[115] Bayer spun out the division because it had relatively low profit margins compared to its life science divisions (10.2%, compared with 24.9% for the agriculture business and 27.5% for healthcare) and because the business required high levels of investment to maintain its growth, and to more clearly focus its efforts and identity in the life sciences.[116] Covestro shares were first offered on the Frankfurt Stock Exchange in October 2015.[117] Effective January 2016 following the spinout of Covestro, Bayer rebranded itself as a life sciences company, and restructured into three divisions and one business unit: Pharmaceuticals, Consumer Health, Crop Science, and Animal Health.[118]

Acquisition of Monsanto

In May 2016, Bayer offered to buy U.S. biotechnology company Monsanto for $62 billion.[119] Shortly after Bayer's offer, Monsanto rejected the acquisition bid, seeking a higher price.[120] In September 2016, Monsanto agreed to a $66 billion offer by Bayer.[121] In order to receive regulatory approval, Bayer agreed to divest a significant amount of its current agricultural assets to BASF in a series of deals.[122] [123] [124] [125] On 21 March 2018 the deal was approved by the European Union,[126] [127] and it was approved in the United States on 20 May 2018.[128] The sale closed on 7 June 2018.[129] The Monsanto brand was discontinued; its products are now marketed under the Bayer name.[130] On 16 September 2019, under the approval of National Company Law Tribunal, Bayer completed the merger of Monsanto India.[131]

Bayer's Monsanto acquisition is the biggest acquisition by a German company to date.[132] However, owing to ongoing litigation concerning the Monsanto's herbicide Roundup and the massive financial and reputational blows it has caused Bayer, the deal is considered one of the worst corporate mergers in history.[133] [134] [135] By 2023, Bayer's market value had declined by over 60% since its 2016 merger, leaving the company's overall worth at less than half of what it paid to acquire Monsanto.[136]

Acquisition history

Corporate structure

Sales by business unit (2023)[137] !Business unit!share
Crop Science48.8%
Pharmaceuticals38.0%
Consumer Health12.7%
Other0.5%
In 2003, to separate operational and strategic managements, Bayer AG was reorganized into a holding company. The group's core businesses were transformed into limited companies, each controlled by Bayer AG. These companies were: Bayer CropScience AG; Bayer HealthCare AG; Bayer MaterialScience AG and Bayer Chemicals AG, and the three service limited companies Bayer Technology Services GmbH, Bayer Business Services GmbH and Bayer Industry Services GmbH & Co. OHG. In 2016, the company began a second restructuring with the aim of allowing it to transition to a life sciences based company.[138] By divesting its Chemicals division in 2004 and with the aim of off-loading its Materials division by mid-2016, Bayer will be left with the four core units, as depicted below.[139] [140]

Bayer CropScience

Bayer CropScience has products in crop protection (i.e. pesticides), nonagricultural pest control, and seeds and plant biotechnology. In addition to conventional agrochemical business, it is involved in genetic engineering of food.[141] In 2002, Bayer AG acquired Aventis (now part of Sanofi) CropScience and fused it with their own agrochemicals division (Bayer Pflanzenschutz or "Crop Protection") to form Bayer CropScience; the Belgian biotech company Plant Genetic Systems became part of Bayer through the Aventis acquisition. Also in 2002, Bayer AG acquired the Dutch seed company Nunhems, which at the time was one of the world's top five seed companies.[142] [143] In 2006, the U.S. Department of Agriculture announced that Bayer CropScience's LibertyLink genetically modified rice had contaminated the U.S. rice supply. Shortly after the public learned of the contamination, the E.U. banned imports of U.S. long-grain rice and the futures price plunged. In April 2010, a Lonoke County, Arkansas jury awarded a dozen farmers $48 million. The case was appealed to the Arkansas Supreme Court, which affirmed the judgement.[144] On 1 July 2011, Bayer CropScience agreed to a global settlement for up to $750 million.[145] In September 2014, the firm announced plans to invest $1 billion in the United States between 2013 and 2016. A Bayer spokesperson said that the largest investments will be made to expand the production of its herbicide Liberty. Liberty is an alternative to Monsanto's product, Roundup, which are both used to kill weeds.[146] In 2016, as part of the wholesale corporate restructuring, Bayer CropScience became one of the three major divisions of Bayer AG, reporting directly to the head of the division, Liam Condon.[147] Under the terms of the merger, Bayer promised to maintain Monsanto's more than 9,000 U.S. jobs and add 3,000 new U.S. high-tech positions.[148] The prospective merger parties said at the time the combined agriculture business planned to spend $16 billion on research and development over the next six years and at least $8 billion on research and development in the United States.[149] The global headquarters of Bayer CropScience is located in St. Louis, Missouri, United States.[150] [151] [152]

Bayer CropScience Limited is the Indian subsidiary of Bayer AG. It is listed on the Indian stock exchanges; the Bombay Stock Exchange and National Stock Exchange of India, and has a market capitalization of $2 billion.[153] Bayer BioScience, headquartered in Hyderabad, India, has about 400 employees, and has research, production, and an extensive sales network spread across India.[154] [155]

Bayer Consumer Health

Before the 2016 restructuring, Bayer HealthCare comprised a further four subdivisions: Bayer Schering Pharma, Bayer Consumer Care, Bayer Animal Health and Bayer Medical Care. As part of the corporate restructuring, Animal Health was moved into its own business unit, leaving the division with the following categories; Allergy, Analgesics, Cardiovascular Risk Prevention, Cough & Cold, Dermatology, Foot Care, Gastrointestinals, Nutritionals and Sun Care.[156]

Bayer Consumer Care manages Bayer's OTC medicines portfolio. Key products include analgesics such as Bayer Aspirin and Aleve, food supplements Redoxon and Berocca, and skincare products Bepanthen and Bepanthol. Women's healthcare is an example of a General Medicine business unit. Bayer Pharma produces the birth control pills Yaz and Yasmin. Both pills use a newer type of progestin hormone called drospirenone in combination with estrogen. Yaz is advertised as a treatment for premenstrual dysphoric disorder (PMDD) and moderate acne. Other key products include the cancer drug Nexavar, the multiple sclerosis drug betaferon/betaseron and the blood-clotting drug, Kogenate.[141] In May 2014, it was announced that Bayer would buy Merck & Co's consumer health care unit for $14.2 billion.[157] Bayer also controls Dihon Pharmaceutical Group Co., Ltd in China.[158]

Bayer Pharmaceuticals

The Pharmaceuticals Division focuses on prescription products, especially for women's healthcare and cardiology, and also on specialty therapeutics in the areas of oncology, hematology and ophthalmology. The division also comprises the Radiology Business Unit which markets contrast-enhanced diagnostic imaging equipment together with the necessary contrast agents.[159]

In addition to internal R&D, Bayer has participated in public–private partnerships. One example in the area of non-clinical safety assessment is the InnoMed PredTox program.[160] [161] Another is the Innovative Medicines Initiative of EFPIA and the European Commission.[162]

Defunct business units

Bayer Chemicals AG (with the exception of H.C. Starck and Wolff Walsrode) was combined with certain components of the polymers segment to form the new company Lanxess on 1 July 2004; Lanxess was listed on the Frankfurt Stock Exchange in early 2005.[163] Bayer HealthCare's Diagnostics Division was acquired by Siemens Medical Solutions in January 2007.[164]

Bayer sold its Animal Health business to Elanco in 2020.[165]

Bayer Diabetes Care managed Bayer's medical devices portfolio. Key products included the blood glucose monitors Contour Next EZ (XT), Contour, Contour USB and Breeze 2 used in the management of diabetes. The diabetes business unit was sold to Panasonic Healthcare Co. for $1.15 billion in June 2015.[166] Bayer MaterialScience was a supplier of high-tech polymers, and developed solutions for a broad range of applications relevant to everyday life. On 18 September 2014, the Board of Directors of Bayer AG announced plans to float the Bayer MaterialScience business on the stock market as a separate entity.[167] On 1 June 2015, Bayer announced that the new company would be named Covestro;[168] Bayer formally spun out Covestro in September 2015.[116]

Ownership

The 10 largest shareholder of Bayer AG in early 2024 were:[137]

Shareholder namePercentage
Temasek Holdings3.5%
Norges Bank3.1%
Silchester International Investors3.0%
Amundi0.9%
MFS Investment Management (UK)0.6%
Universal-Investment-Gesellschaft mbH0.5%
Lyxor0.4%
Union Investment Institutional GmbH0.4%
Union Investment Privatfonds GmbH0.4%
HSBC Global Asset Management GmbH0.4%
Others86.8%

Finances

For the fiscal year 2017, Bayer reported earnings of EUR€7.3 billion, with an annual revenue of EUR€35 billion, a decrease of 25.1% over the previous fiscal cycle.[169] Bayer's shares traded at over €69 per share, and its market capitalization was valued at US€65.4 billion in November 2018.[170] In September 2019, Bayer announced to reduce the number of management board members from seven to five to reduce overall costs.[171]

The key trends of Bayer are (as at the financial year ending December 31):[172] [173]

YearRevenue
(€ bn)		Net income
(€ bn)		Total assets
(€ bn)		Research and development
expenses (€ bn)		Employees
201340.13.151.33.4112,360
201442.23.470.23.5118,888
201546.34.173.94.2116,800
201646.74.582.24.4115,200
2017*35.07.375.04.599,820
201839.51.61265.1107,894
201943.54.01265.3103,824
202041.4−10.41177.199,538
202144.01.01205.499,637
202250.74.11246.5101,369
202347.6−2.912399,723
* without Covestro from 2017 on

Bayer 04 Leverkusen

See main article: Bayer 04 Leverkusen. In 1904, the company founded the sports club TuS 04 ("Turn- und Spielverein der Farbenfabriken vorm. Friedr. Bayer & Co."), later SV Bayer 04 ("Sportvereinigung Bayer 04 Leverkusen"), finally becoming TSV Bayer 04 Leverkusen ("Turn- und Sportverein") in 1984, generally, however, known simply as Bayer 04 Leverkusen. The club is best known for its football team, but has been involved in many other sports, including athletics, fencing, team handball, volleyball, boxing, and basketball. TSV Bayer 04 Leverkusen is one of the largest sports clubs in Germany. The company also supports similar clubs at other company sites, including Dormagen (particularly handball), Wuppertal (particularly volleyball), and Krefeld-Uerdingen (featuring another former Bundesliga football club, SC Bayer 05 Uerdingen, now KFC Uerdingen 05).[174]

Awards and recognition

In October 2008, Bayer's Canadian division was named one of "Canada's Top 100 Employers" by Mediacorp Canada Inc. The Canadian division was named one of Greater Toronto's Top Employers by the Toronto Star newspaper.[175] Bayer USA was given a score of 85 (out of 100) in the Human Rights Campaign's 2011 Corporate Equality Index, a measure of gay and lesbian workplace equality.[176]

In 2016, Standard Ethics Aei gave a rating to Bayer in order to include the company in its Standard Ethics German Index. Bayer received an EE− rating, the fourth tier in an eight-tier ranking.[177]

Ranked third in Access to Seeds Index in 2016.[178] [179]

Litigation

Roundup

In August 2018, two months after Bayer acquired Monsanto,[180] a U.S. jury ordered Monsanto to pay $289 million to a school groundskeeper who claimed his Non-Hodgkin's lymphoma was caused by regularly using Roundup, a glyphosate-based herbicide produced by Monsanto.[181] Following the Johnson v. Monsanto Co. verdict, Bayer's share price dropped by around 14% or $14 Billion in market capitalization.[182] The company filed an appeal on 18 September 2018.[183] Pending appeal, the award was later reduced to $78.5 million.[184] [185] In November 2018, Monsanto appealed the judgement, asking an appellate court to consider a motion for a new trial.[185] A verdict on the appeal was delivered in June 2020 upholding the verdict but further reducing the award to $21.5 million.[186] On 13 May 2019, a United States Superior Court Judge ordered Bayer to pay more than $ 2.5 billion in damages to a couple in California, both of whom contracted non-Hodgkin's Lymphoma, later cut to $87 million on appeal.[187]

In June 2020, the company agreed to pay $9.6 billion to settle more than 10,000 lawsuits claiming harm from Roundup, saying this action will result in the resolution of 75% of those claims. Bayer will also assign $1.25 billion for future claims, an action that needs approval from the US District Court, Northern District of California. The settlement, according to the company, does not admit either liability or wrongdoing, but brings an end to irresolution in the case.[188] The settlement does not include three cases that have already gone to jury trials and are being appealed. In July 2020, the California Court of Appeals denied the appeal but reduced the damages owed to $20.4 million.[189] As of 2023, around 165,000 claims, more than 50.000 of which still pending, have been made against Roundup, mostly alleging that it had caused cancer.[190]

The general consensus among national regulatory agencies, and the European Commission is that labeled usage of the herbicide poses no carcinogenic or genotoxic risk to humans.[191] [192] [193] [194] In January 2020, the US Environmental Protection Agency (EPA) finalized its interim registration review for Roundup, stating that it "...did not identify any risks of concern" for cancer and other risks to humans from glyphosate exposure."[188] On 17 June 2022, California-based United States Court of Appeals for the Ninth Circuit ordered the Environmental Protection Agency to reexamine this 2020 finding that glyphosate did not pose a health risk for people exposed to it by any means.[195]

Xarelto

In 2019, Bayer and Johnson & Johnson (who market Xarelto together) settled around 25,000 lawsuits on the blood thinning drug Xarelto (rivaroxaban) by agreeing to disburse $775 million (US) to federal and state plaintiffs who said the companies had not properly warned patients about possible fatal bleeding as a result of ingesting the drug. There was no admission of liability from the companies in the settlement as they noted they had prevailed in six previous trials. The settlement will be divided evenly between the companies.[196]

One A Day Vitamins

In 2019, a federal jury in San Francisco CA sided with Bayer in a $600 million (US) class action suit alleging that the company misinformed consumers by promoting its One A Day vitamins as supporting cardiac health, vigorous immune systems and boosting user energy. The suit was first filed as a nationwide class action; in 2017, the US District Court in San Francisco said subclasses of purchasers of the vitamin in Florida, New York, and California could act together.[197]

The jury found that the plaintiffs failed to prove that Bayer misrepresented its One A Day claims, and also did not demonstrate that any of the class representative consumers who purchased One A Day relied on the so-called false information as part of their buying decision.[198]

HIV contamination

In the mid-1980s, when Bayer's Cutter Laboratories realized that their blood products, the clotting agents Factor VIII and IX, were contaminated with HIV, the financial investment in the product was considered too high to destroy the inventory. Bayer misrepresented the results of its own research and knowingly supplied hemophilia medication tainted with HIV to patients in Asia and Latin America, without the precaution of heat treating the product, recommended for eliminating the risk. As a consequence, thousands who infused the product tested positive for HIV and later developed AIDS.[199]

Dicamba

On 14 February 2020, Bayer and BASF were ordered to pay Missouri peach farmer Bill Bader $15 million in damages as a result of destruction of his peach trees which was caused by the usage of dicamba by nearby farmers.[200] Dicamba was another product which Bayer acquired from Monsanto.[201] Bayer also inherited the lawsuit from Monsanto as well.[202] [203] On 15 February 2020, Bayer - representing Monsanto - and BASF were ordered to pay not only the $15 million in damages, but an additional $250 million in punitive damages.[204] Bayer and BASF afterwards announced plans to appeal the $265 million fine.[205]

In June 2020, Bayer agreed to a settlement of up to $400 million for all 2015–2020 crop year dicamba claims, not including the $265 million judgement.[206] On 25 November 2020, U.S. District Judge Stephen Limbaugh Jr. reduced the punitive damage amount in the Bader Farms case to $60 million.[207]

PCB pollution

In June 2020, Bayer agreed to pay $800 million to settle lawsuits in a variety of jurisdictions which claimed contamination of public waterways with PCBs by Monsanto before 1978. On 25 November 2020, however, U.S. District Judge Fernando M. Olguin rejected Bayer's settlement offer, which was now at $650 million, and allowed Monsanto-related lawsuits involving PCB to proceed.[208]

Talc-related liabilities

On 4 April 2023, a Delaware judge dismissed a lawsuit by Merck & Co’s seeking to hold Bayer AG responsible for more talc-related liabilities stemming from its $14.2 billion purchase of Merck’s consumer care business in 2014. The judge called Bayer’s interpretation of the purchase agreement “the only reasonable one,” and said letting Merck “dump” cases would give the Rahway, New Jersey-based company an incentive to prolong or stall lawsuits. Bayer said in a statement, it welcomed the decision, and it "will continue to defend itself against any further efforts by Merck to avoid or improperly transfer its liabilities to Bayer”.[209]

See also

References

Works cited

Book: Lifton . Robert Jay . Robert Jay Lifton. Amy . Hackett. Berenbaum . Michael. Michael Berenbaum . Gutman . Yisrael. Yisrael Gutman . Anatomy of the Auschwitz Death Camp . 1998 . Indiana University Press . Bloomington. Nazi Doctors. 301–316.

Further reading

External links

Notes and References

  1. Web site: History of Bayer: 1863–1881. Bayer AG.
  2. Web site: Bayer AG Annual Report 2022 . 15 September 2023 . Bayer AG.
  3. Web site: Kim . Susanna . September 4, 2014 . Ikea and Other Brand Names You've Been Mispronouncing . live . https://web.archive.org/web/20221002142040/https://abcnews.go.com/Business/ikea-brand-names-mispronouncing/story?id=25248511 . Oct 2, 2022 . ABC News.
  4. Web site: Euro Stoxx 50, Börse Frankfurt (Frankfurt Stock Exchange) . https://web.archive.org/web/20170118100901/http://en.boerse-frankfurt.de/index/constituents/Euro_Stoxx_50 . Jan 18, 2017 . 17 January 2017 . Deutsche Boerse.
  5. Book: ((World Health Organization)) . The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) . 2023 . 10665/371090 . World Health Organization . World Health Organization . Geneva . WHO/MHP/HPS/EML/2023.02 . free .
  6. Web site: The Top 300 of 2021 . ClinCalc . 14 January 2024 . 15 January 2024 . https://web.archive.org/web/20240115223848/https://clincalc.com/DrugStats/Top300Drugs.aspx . live .
  7. Web site: Aspirin - Drug Usage Statistics, US 2013-2021. 14 January 2024. ClinCalc.
  8. Web site: Gerhard Domagk .
  9. News: Law No. 9 . Allied Control Council. https://web.archive.org/web/20180922015412/http://images.library.wisc.edu/History/EFacs/GerRecon/PropControl/reference/history.propcontrol.i0039.pdf. 22 September 2018. live.
  10. Web site: Bayer . live . https://web.archive.org/web/20211108110822/https://encyclopedia.ushmm.org/content/en/article/bayer . 2021-11-08 . 2021-11-08 . Holocaust Encyclopedia.
  11. Web site: 8 Convicted Nazi War Criminals Who Got Off Easy . 2024-08-18 . History Hit . en-GB.
  12. News: Klawitter . Nils . 2017-04-24 . Deutsche Unternehmen haben vom Nationalsozialismus profitiert . 2024-08-18 . Der Spiegel . de . 2195-1349.
  13. News: Sherman . Ruth Bender Graphics by Merrill . 28 August 2019 . How Bayer-Monsanto Became One of the Worst Corporate Deals—in 12 Charts . en-US . Wall Street Journal . 2019-09-23.
  14. Web site: 29 August 2019 . Worst deal ever? Bayer's market cap now close to the total cost it paid for Monsanto . 2019-09-23 . FiercePharma.
  15. News: Randazzo . Sara . 2021-02-03 . Bayer Tries Again to Limit Roundup Liability . en-US . . 2021-02-04 . 0099-9660.
  16. News: Farrell . Maureen . 2023-12-06 . Years After Monsanto Deal, Bayer's Roundup Bills Keep Piling Up . en-US . The New York Times . subscription . 2023-12-06.
  17. Web site: Fagin . Dan . Dye Me a River: How a Revolutionary Textile Coloring Compound Tainted a Waterway [Excerpt] ]. 2023-07-04 . Scientific American . en.
  18. Web site: The mordant dyestuffs of the Farbenfabriken vorm. Friedr. Bayer & Co., Elberfeld, and their application to printing and dyeing . 2023-07-04 . NYPL Digital Collections . en.
  19. Europe Tourism. 5 March 2015 landmarks Landmarks: Cologne: Nearby Attractions
  20. News: 'Genericide': Brands destroyed by their own success. Simon. Tulett. 28 May 2014. BBC News.
  21. Fuster. Valentin. Sweeny. Joseph M. . Aspirin: A Historical and Contemporary Therapeutic Overview . Circulation . 123 . 7 . 768–778 . 22 February 2011 . 21343593 . 10.1161/CIRCULATIONAHA.110.963843 . free .
  22. Web site: WHO Model List of EssentialMedicines . World Health Organization . October 2013.
  23. Felix Hoffmann ist der "Vater" des Aspirin. September 1999. Bayer AG, courtesy of LaHave Media Services Limited. https://web.archive.org/web/20070928132933/http://pressearchiv-kubitschek.www.de/pharma-presse/presseerklaerungen/texte/pharma_medikamente/bayer/bayer_110999.html. dead. 28 September 2007.
  24. 1999. Royal Society of Chemistry. Jewish Scientist's Claim to Discover Aspirin Denied by Nazis. https://web.archive.org/web/20050528215006/http://www.rsc.org/pdf/pressoffice/1999/annconf99press3.pdf. 28 May 2005. dead.
  25. Sneader, Walter. 23 December 2000. The discovery of aspirin: a reappraisal. BMJ. 321 . 7276 . 1591–1594 . 11124191 . 1119266 . 10.1136/bmj.321.7276.1591.
  26. Mahdi. J.G.. Mahdi. A.J.. Mahdi. A.J.. Bowen. I.D. . 16515437. The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential . Cell Proliferation . 39 . 2 . 147–155 . April 2006 . 16542349 . 10.1111/j.1365-2184.2006.00377.x . 6496865.
  27. Moore, Deborah (24 August 2014). "Heroin: A brief history of unintended consequences". Times Union.
  28. Web site: Felix Hoffmann. Science History Institute. 8 December 2017.
  29. Edwards Jim (17 November 2011). "Yes, Bayer Promoted Heroin for Children — Here Are The Ads That Prove It". Business Insider.
  30. Sneader . Walter . The discovery of heroin . The Lancet . 21 November 1998 . 352 . 9141 . 1697–1699 . 10.1016/S0140-6736(98)07115-3 . 9853457 . 1819676 .
  31. Yasiry Z, Shorvon SD . How phenobarbital revolutionized epilepsy therapy: the story of phenobarbital therapy in epilepsy in the last 100 years . Epilepsia . 53 . 26–39 . December 2012 . Suppl 8 . 23205960 . 10.1111/epi.12026 . 8934654 .
  32. López-Muñoz F, Ucha-Udabe R, Alamo C . The history of barbiturates a century after their clinical introduction . Neuropsychiatric Disease and Treatment . 1 . 4 . 329–343 . December 2005 . 18568113 . 2424120 .
  33. Web site: History of Bayer: 1914–1925. Bayer AG.
  34. Web site: Legg, J.. Parker, G.. 2002. The Germans develop a new weapon: the gas cloud. 6 August 2007. The Great War.
  35. Book: Abelshauser, Werner. German Industry and Global Enterprise, BASF: The History of a Company. Cambridge University Press. 2003. 0-521-82726-4.
  36. Fourneau . E. . Th . Vallée . J. . 1924 . Sur une nouvelle série de médicaments trypanocides . Comptes rendus de l'Académie des Sciences . 178 . 675 .
  37. Web site: WHO Model List of EssentialMedicines. World Health Organization. 22 April 2014. October 2013.
  38. Web site: Gerhard Domagk . Nobel Foundation.
  39. Web site: Gerhard Domagk . Science History Institute . https://web.archive.org/web/20180531170910/https://www.sciencehistory.org/historical-profile/gerhard-domagk . 31 May 2018 . 4 December 2017.
  40. Web site: I.G. Auschwitz . Frankfurt. Wollheim Memorial, Fritz Bauer Institute.
  41. Web site: Other doctor-perpetrators . Auschwitz-Birkenau Memorial and Museum . https://web.archive.org/web/20160415062104/http://auschwitz.org/en/history/medical-experiments/other-doctor-perpetrators/ . 15 April 2016. live.
  42. ; .
  43. News: Worthington . Daryl . IG Farben Opens Factory at Auschwitz . New Historian . 20 May 2015 . https://web.archive.org/web/20150522040626/https://www.newhistorian.com/ig-farben-opens-factory-at-auschwitz/3822/ . 22 May 2015. live.
  44. ; that the letter was directed at Höss, see .
  45. News: Stock of former Nazi chemicals giant to be delisted. Gerhard. Schneibel. Deutsche Welle. 19 August 2011.
  46. Web site: Fritz (Friedrich Hermann) ter Meer (1884–1967) . Frankfurt . Wollheim Memorial, Fritz Bauer Institute. 25 February 2012.
  47. News: Bayer's CEO Helge Wehmeier Faces Past and Fights for Future . CNN . 26 January 2002.
  48. Bangen, Hans: Geschichte der medikamentösen Therapie der Schizophrenie. Berlin 1992, p. 98
  49. Web site: Assessment of historical evidence on Primodos and congenital malformations – a synopsis. Medicines and Healthcare products Regulatory Agency. 2014. 12 May 2014. https://web.archive.org/web/20140512215100/http://www.mhra.gov.uk/home/groups/comms-ic/documents/websiteresources/con404471.pdf. 12 May 2014. dead.
  50. https://archive.org/stream/adualtrusttrans02cuttrich/adualtrusttrans02cuttrich_djvu.txt "Cutter Laboratories: 1897–1972. A Dual Trust"
  51. News: 2 Paths of Bayer Drug in 80's: Riskier One Steered Overseas . Bogdanich. Walt. Walt Bogdanich. Koli. Eric. The New York Times . 19 September 2003.
  52. 10.1186/CVM-2-5-205. Furberg . C.. Pitt . B.. Withdrawal of cerivastatin from the world market. Current Controlled Trials in Cardiovascular Medicine. 2. 5. 205–207. 2001. 11806796. 59524 . free .
  53. News: 2008-05-15 . Bayer pulls Trasylol supplies after study . en . Reuters . 2023-07-04.
  54. Web site: Bayer 2014 Annual report . https://web.archive.org/web/20150415062802/http://www.investor.bayer.com/en/overview . 15 April 2015 . Bayer .
  55. Web site: Bayer Annual Report – 2018. 2018. Bayer. 19 May 2019. 31 March 2019. https://web.archive.org/web/20190331091430/https://www.bayer.com/en/bayer-annual-report-2018.pdfx. dead.
  56. Web site: labeling.bayerhealthcare.com. 12 April 2015. 1 July 2015. https://web.archive.org/web/20150701205706/http://labeling.bayerhealthcare.com/html/products/pi/Kogenate_PI.pdf. dead.
  57. Mannucci PM, Mancuso ME, Santagostino E . 36273104 . How we choose factor VIII to treat hemophilia . Blood . 119 . 18 . 4108–14 . 2012 . 22411872 . 10.1182/blood-2012-01-394411 . free .
  58. Web site: www.accessdata.fda.gov.
  59. Sardar P, Chatterjee S, Wu WC, Lichstein E, Ghosh J, Aikat S, Mukherjee D . New oral anticoagulants are not superior to warfarin in secondary prevention of stroke or transient ischemic attacks, but lower the risk of intracranial bleeding: insights from a meta-analysis and indirect treatment comparisons . PLOS ONE . 8 . 10 . e77694 . 2013 . 24204920 . 3808395 . 10.1371/journal.pone.0077694 . 2013PLoSO...877694S . free .
  60. Web site: Highlights of Prescribing Information . Bayer.
  61. News: Yaz and Yasmin pills linked to 23 deaths, say Health Canada documents . Macleans . The Canadian Press . 11 June 2013. Web site: Health Canada reviewing safety of drospirenone-containing oral contraceptives (Yasmin and Yaz) and risk of venous thromboembolism . Health Canada . 7 June 2011. Web site: Yasmin and Yaz (drospirenone): Updated information on increased risk of blood clots . Health Canada . 5 December 2011.
  62. Stegeman BH, de Bastos M, Rosendaal FR . Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis . BMJ . 347 . f5298 . 2013 . 24030561 . 3771677 . 10.1136/bmj.f5298. etal.
  63. Book: 10.1007/978-3-642-54490-3_8 . Sorafenib: Targeting Multiple Tyrosine Kinases in Cancer . Small Molecules in Oncology . Recent Results in Cancer Research . 2014 . Hasskarl . Jens . 201 . 145–164 . 24756790 . 978-3-642-54489-7 .
  64. Web site: FDA Statement Regarding New Trasylol Data. Food and Drug Administration.
  65. News: Harris . Gardiner . F.D.A. Says Bayer Failed to Reveal Drug Risk Study . The New York Times . 30 September 2006 .
  66. Web site: FDA Revises Labeling for Trasylol (Aprotinin Injection) to Strengthen Safety Warnings and Limit Usage of Drug to Specific Situations. Food and Drug Administration.
  67. Web site: FDA Requests Marketing Suspension of Trasylol. Food and Drug Administration.
  68. Web site: MedEffect – Health Canada's Response to the Final Report of the Expert Advisory Panel on Trasylol (aprotinin) . https://web.archive.org/web/20150402043811/http://www.hc-sc.gc.ca/dhp-mps/medeff/res/hc-sc_res-rep-trasylol-eng.php . 2 April 2015 . dead .
  69. Web site: Aprotinin Reintroduction Puts Lives at Risk in Canada, EU . Medscape . 29 September 2014 . 18 April 2015 . Wood, Shelly.
  70. McMullan V, Alston RP . III. Aprotinin and cardiac surgery: a sorry tale of evidence misused . Br J Anaesth . 110 . 5 . 675–8 . 2013 . 23599511 . 10.1093/bja/aet008 . free .
  71. Web site: www.ema.europa.eu. 17 April 2015. 18 April 2015. https://web.archive.org/web/20150418004401/http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Antifibrinolytic_medicines/WC500122924.pdf. dead.
  72. Goossens H, Ferech M, Coenen S, Stephens P . Comparison of outpatient systemic antibacterial use in 2004 in the United States and 27 European countries . Clin. Infect. Dis. . 44 . 8 . 1091–5 . April 2007 . 17366456 . 10.1086/512810 . European Surveillance of Antimicrobial Consumption Project Group . free .
  73. Web site: British Columbia Annual Summary of Antibiotics Utilization 2010. https://web.archive.org/web/20131230232309/http://www.bccdc.ca/NR/rdonlyres/BC629780-7E03-4153-B67B-5CFD4F521DAC/0/Full2010AntibioticConsumptionReport_aug2012.pdf. 30 December 2013. dead.
  74. Drug topics June 2011 2010 Top 200 generic drugs by total prescriptions
  75. News: A breakdown of the over-the-counter medicines market in Britain in 2016. 29 May 2017. Pharmaceutical Journal. 28 April 2017. 22 October 2019. https://web.archive.org/web/20191022174148/https://www.pharmaceutical-journal.com/20202662.article. dead.
  76. Web site: Bayer's Agricultural Products . 15 April 2015.
  77. Web site: Fungicide list. 15 April 2015. https://web.archive.org/web/20150416011948/http://www.cropscience.bayer.com/en/Products-and-Innovation/Brands/Fungicides.aspx. 16 April 2015. dead.
  78. Web site: Nativo label. 20 August 2015.
  79. Web site: Nativo label. 15 April 2015. https://web.archive.org/web/20150416015851/http://www.bayercropscience.ie/manual/Nativo_75_WG.pdf. 16 April 2015. dead.
  80. Web site: Xpro label. 15 April 2015. https://web.archive.org/web/20150416005436/http://www.bayercropscience.ie/manual/Aviator_Xpro.pdf. 16 April 2015. dead.
  81. Web site: Luna label.
  82. Web site: Herbicide list. 15 April 2015. https://web.archive.org/web/20150416005741/http://www.cropscience.bayer.com/en/Products-and-Innovation/Brands/Herbicides.aspx. 16 April 2015. dead.
  83. Web site: Liberty label.
  84. Web site: Capreno label.
  85. Web site: Insecticide list. 15 April 2015. https://web.archive.org/web/20150416004829/http://www.cropscience.bayer.com/en/Products-and-Innovation/Brands/Insecticides.aspx. 16 April 2015. dead.
  86. Web site: Belt label.
  87. Web site: Movento label.
  88. Web site: Poncho label.
  89. Web site: Gaucho label.
  90. Cressey . D. . Europe debates risk to bees . 10.1038/496408a . Nature . 496 . 7446 . 408 . 2013 . 23619669. 2013Natur.496..408C . free .
    Gill . R. J. . Ramos-Rodriguez . O. . Raine . N. E. . 10.1038/nature11585 . Combined pesticide exposure severely affects individual- and colony-level traits in bees . Nature . 491 . 7422 . 105–108 . 2012 . 23086150. 3495159 . 2012Natur.491..105G .
    Dicks . L. . Bees, lies and evidence-based policy . 10.1038/494283a . Nature . 494 . 7437 . 283 . 2013 . 23426287. 2013Natur.494..283D . free .
    Stoddart . C. . 10.1038/nature.2012.11626 . The buzz about pesticides . Nature . 2012 . 208530336 . free .
    Osborne . J. L. . Ecology: Bumblebees and pesticides . 10.1038/nature11637 . Nature . 491 . 7422 . 43–45 . 2012 . 23086148. 2012Natur.491...43O . 532877 .
    Cressey . D. . 10.1038/nature.2013.12234 . Reports spark row over bee-bothering insecticides . Nature . 2013 . 88428354 .
    "Nature Studies by Michael McCarthy: Have we learned nothing since 'Silent Spring'?" The Independent 7 January 2011
    "Do people know perfectly well what’s killing bees?" IO9.com 6 January 2011
  91. http://ec.europa.eu/food/animal/liveanimals/bees/neonicotinoids_en.htm Bees & Pesticides: Commission goes ahead with plan to better protect bees.
  92. News: 'Victory for bees' as European Union bans neonicotinoid pesticides blamed for destroying bee population. The Independent. 29 April 2013. Charlotte. McDonald-Gibson. 31 May 2024. London.
  93. http://extoxnet.orst.edu/pips/propoxur.htm EXTOXNET Extension Toxicology Network. Pesticide Information Profile. Propoxur.
  94. News: OLMOS. DAVID. German Firm to Reclaim Bayer Aspirin Name : Drugs: It will acquire Sterling Winthrop's over-the-counter business and recover the rights it lost after WWI. 3 May 2013. LA Times. 14 September 1994.
  95. Sale of Roche Consumer Health to Bayer completed. 3 January 2005. Roche. https://web.archive.org/web/20160917084811/http://www.roche.com/media/store/releases/med-cor-2005-01-03.htm. 17 September 2016.
  96. http://www.bayer.com/en/News-Detail.aspx?id=10657 Bayer HealthCare to acquire OTC Business of Sagmel, Inc
  97. News: Bayer Buys Over-the-Counter Health Unit From Sagmel . Bloomberg . 11 March 2008.
  98. Web site: Bayer CropScience Pesticide Waste Tank Explosion. 4 September 2014. U.S. Chemical Safety Board.
  99. Web site: Bayer Pesticide Plant Disaster, 2008, Institute, West Virginia . Semp.us . 14 June 2011. https://web.archive.org/web/20110718140150/http://www.semp.us/publications/biot_reader.php?BiotID=619. 18 July 2011 . live.
  100. Web site: 2005 a Record Year for Schering AG . Shering AG press release, PR Newswire . https://web.archive.org/web/20161008072507/http://www.prnewswire.com/news-releases/2005-a-record-year-for-schering-ag-55363567.html . 8 October 2016 . 20 February 2006. dead.
  101. Laforte, Marie-Eve (12 July 2006). Bayer completes acquisition of Schering AG. First Word Pharma.
  102. News: The Daily Telegraph . Bayer acquires Schering in €17bn deal. https://ghostarchive.org/archive/20220111/https://www.telegraph.co.uk/finance/2941133/Bayer-acquires-Schering-in-17bn-deal.html . 11 January 2022 . subscription . live. Katherine. Griffiths. 25 June 2006.
  103. Staff (13 April 2015). "Healthy appetite – the ten biggest pharmaceutical takeovers". Pharmaceutical Technology.
  104. Web site: Bayer Acquires Animal Health Co Bomac in New Zealand. Nasdaq. 3 November 2010.
  105. News: Algeta Board OKs $2.9B Acquisition by Bayer . . . 10 . 15 January 2014 . paper . 34 . 2 .
  106. Web site: Bayer and Merck – Investment Information. spiderbook.com. 18 August 2014. https://web.archive.org/web/20140819091054/http://spiderbook.com/company/117638/details?rel=304110&show_current=True&show_others=True&people_page=0&document_page=0&current_tab=supporting_documents. 19 August 2014. dead.
  107. News: Ludwig . Burger . Bayer sells Diabetes Care business to Panasonic Healthcare . Reuters . 10 June 2015 . 10 June 2015 . 12 June 2015 . https://web.archive.org/web/20150612045536/http://www.reuters.com/article/2015/06/10/us-bayer-m-a-kkr-idUSKBN0OQ0KF20150610 . live .
  108. Web site: Bayer acquires BlueRock Therapeutics to build leading position in cell therapy . 8 August 2019 . BioSpace . 27 November 2019 .
  109. Web site: Already Owning 40.8% of BlueRock Therapeutics, Bayer Buys Rest of Company for $600 Million. BioSpace.
  110. Web site: Bayer Bolsters Women's Health Pipeline with Acquisition of KaNDy Therapeutics.
  111. Web site: Bayer to Acquire UK-Based Biotech KaNDy Therapeutics Ltd.. BioSpace.
  112. News: Bayer takes on Astellas in purchase of experimental menopause relief. Reuters . 11 August 2020. www.reuters.com.
  113. Web site: Conover. Damien. 26 October 2020. Bayer's Announced Acquisition Adds Needed Boost. 2020-11-13. Morningstar.com. en. 27 October 2020. https://web.archive.org/web/20201027202850/https://www.morningstar.com/articles/1006344/bayers-announced-acquisition-adds-needed-boost. dead.
  114. Web site: Bayer Acquires Noria and PSMA Therapeutics to Expand Pipeline in Prostate Cancer.
  115. Gannon, Joyce (1 September 2015). "Bayer MaterialScience assumes its new identity as Covestro". Pittsburgh Post-Gazette.
  116. Alessi, Christopher (1 September 2015). "Bayer Separates Material Science Business Covestro". Wall Street Journal.
  117. Matthews, Sheenagh and Webb, Alex (6 October 2015). "Covestro Jumps on First Day of Trading in Frankfurt After IPO". Bloomberg News.
  118. Bayer, 2015 Annual Report. Corporate Structure
  119. News: . 23 March 2016. Bayer defies critics with $62 billion Monsanto offer. Ludwig . Burger . Georgina . Prodhan . 23 March 2016.
  120. News: Reuters . 24 March 2016. Exclusive: Monsanto to reject Bayer bid seeking a higher price – sources. 24 March 2016.
  121. Web site: Bayer confirms $66bn Monsanto takeover. 14 September 2016. BBC News. 5 June 2018.
  122. News: BASF: The unexpected winner in the Bayer-Monsanto merger. 22 March 2018. Handelsblatt Global Edition. 5 June 2018. en-US.
  123. News: Bayer Will Sell More Units to BASF in Bid to Clinch Monsanto. 26 April 2018. Bloomberg News. 5 June 2018. en.
  124. News: Bayer to Sell Assets to BASF for $7 Billion Amid Scrutiny of Monsanto Megadeal. Shevlin. Anthony. 13 October 2017. The Wall Street Journal. 5 June 2018. Drozdiak. Natalia. en-US. 0099-9660.
  125. News: Competition Bureau asks Bayer to divest some Canadian assets to win Monsanto deal approval. The Globe and Mail. 5 June 2018.
  126. News: Bayer Clears EU Hurdle for Monsanto Deal With BASF Sale. Aoife. White. Bloomberg News. 21 March 2018.
  127. News: US set to approve Bayer-Monsanto deal with divestures. Financial Times. 29 May 2018 . 5 June 2018 . subscription.
  128. News: Bayer Wins U.S. Approval for Monsanto After Two-Year Quest. 29 May 2018. Bloomberg.com. 5 June 2018. en.
  129. Bayer closes Monsanto acquisition. 7 June 2018. 25 June 2018. Bayer AG.
  130. News: Bayer to ditch Monsanto name after closing €54bn deal. The Irish Times. 5 June 2018. en-US.
  131. News: Bayer completes merger of Monsanto India. 2019-09-16. The Economic Times. 2019-09-17.
  132. News: How Bayer-Monsanto Became One of the Worst Corporate Deals—in 12 Charts. Sherman. Ruth Bender Graphics by Merrill. Wall Street Journal. 28 August 2019. en-US. 2019-09-23.
  133. Web site: Worst deal ever? Bayer's market cap now close to the total cost it paid for Monsanto. FiercePharma. 29 August 2019 . en. 2019-09-23.
  134. News: Randazzo. Sara. 2021-02-03. Bayer Tries Again to Limit Roundup Liability. en-US. The Wall Street Journal. 2021-02-04. 0099-9660.
  135. News: Farrell . Maureen . 2023-12-06 . Years After Monsanto Deal, Bayer's Roundup Bills Keep Piling Up . en-US . The New York Times . 2023-12-06 . subscription.
  136. News: Farrell . Maureen . 2023-12-06 . Years After Monsanto Deal, Bayer's Roundup Bills Keep Piling Up . en-US . The New York Times . 2023-12-06 . https://web.archive.org/web/20231206112824/https://www.nytimes.com/2023/12/06/business/monsanto-bayer-roundup-lawsuit-settlements.html . December 6, 2023.
  137. Web site: Bayer AG: Shareholders Board Members Managers and Company Profile DE000BAY0017 . 2024-05-31 . MarketScreener.
  138. Web site: Bayer organises its Life Science businesses into three divisions: Pharmaceuticals, Consumer Health and Crop Science. www.manufacturingchemist.com.
  139. Web site: Names, Facts, Figures about Bayer . 31 December 2015 . Bayer . 7 March 2016 .
  140. Web site: Bayer aligns organization with Life Science businesses – Bayer News. 6 March 2016. https://web.archive.org/web/20160301035101/http://www.press.bayer.com/baynews/baynews.nsf/id/Bayer-aligns-organization-with-Life-Science-businesses. 1 March 2016. dead.
  141. Web site: Annual Report 2010 . 1 March 2011 . Bayer . 29 May 2012 . https://web.archive.org/web/20120529105132/http://www.annualreport2010.bayer.com/en/Bayer-Annual-Report-2010.pdfx . dead .
  142. Fruitnet. 4 April 2014 Bayer Cropscience rebrands Nunhems
  143. Ram HH and Yadava, R. Genetic Resources and Seed Enterprises: Management and Policies. New India Publishing, 2007
  144. Web site: Bayer CropScience LP v. Schafer. 2021-09-19. Justia Law. en.
  145. News: Bloomberg L.P.. Bayer Settles With Farmers Over Modified Rice Seeds. The New York Times . 1 July 2011.
  146. https://www.reuters.com/article/us-bayer-cropscience-usa-idUSKBN0GY25720140903 Bayer CropScience to invest $1 billion in U.S. by 2016
  147. Patel, Nikhil (30 September 2015). "Bayer restructures its operations, drops Bayer Healthcare group" . PMLive.
  148. News: Bayer, Monsanto pledge U.S. R&D spending, jobs after merger. Reuters . 17 January 2017. www.reuters.com.
  149. Web site: Monsanto Shares up on Bayer-Trump Promise for Billions in U.S. Investment, Jobs. Fox Business. 13 January 2017.
  150. Web site: Bayer, Monsanto plan $16 billion in R&D spending, half in the U.S. – St. Louis Business Journal. dead. https://web.archive.org/web/20170118132412/http://www.bizjournals.com/stlouis/news/2017/01/17/bayer-will-keep-monsanto-jobs-invest-8-billion-if.html. 2017-01-18.
  151. Web site: Missouri Partnership | Economic Development | Bayer & Monsanto Complete Merger, Establish Global Seeds & Traits and North American Headquarters in Missouri. 11 June 2018.
  152. Web site: St. Louis-based Bayer Crop Science names successor to retiring Begemann . St. Louis Business Journal . Edwards . Greg . 18 May 2021 . 1 June 2022.
  153. Web site: Bayer CropScience. moneycontrol.com.
  154. http://www.bayergroupindia.com/bio_science.html Bayer
  155. Web site: Bayer launches multi-crop breeding station in Hyderabad. Our Bureau. The Hindu Business Line.
  156. Web site: Bayer restructures, appoints new board members.
  157. News: Bayer to Buy Merck Consumer-Health Unit for $14.2 Billion . Bloomberg . Naomi . Kresge . 6 May 2014.
  158. Web site: Bayer Focuses on Life Sciences.
  159. Web site: Profile of Pharmaceuticals at Bayer.
  160. Book: Mattes . William B.. Public Consortium Efforts in Toxicogenomics . 10.1007/978-1-60327-048-9_11 . Essential Concepts in Toxicogenomics. Mendrick . Donna L.. Mattes . William B.. Methods in Molecular Biology. 460 . 221–238 . 2008 . 978-1-58829-638-2 . 18449490 .
  161. Web site: InnoMed PredTox Member Organizations. 25 August 2008. https://web.archive.org/web/20080926214522/http://www.innomed-predtox.com/consortium/members/. 26 September 2008. dead.
  162. Web site: IMI Call Topics 2008. Innovative Medicines Initiative. IMI-GB-018v2-24042008-CallTopics.pdf. European Commission. 25 August 2008. https://web.archive.org/web/20091015122459/http://imi.europa.eu/docs/calls01_en.zip. 15 October 2009. dead.
  163. Web site: History – LANXESS. 16 September 2016. 10 September 2016. https://web.archive.org/web/20160910220759/http://lanxess.com/en/corporate/about-lanxess/history/. dead.
  164. Acquisition of Bayer's Diagnostic Division Finalized. Business Wire.
  165. Web site: Bayer to sell its Animal Health business unit to Elanco for 7.6 billion U.S. dollars. Bayer AG. Communications. Bayer to sell its Animal Health business unit to Elanco for 7.6 billion U.S. dollars. 13 November 2021. 10 November 2021. https://web.archive.org/web/20211110123832/https://media.bayer.com/baynews/baynews.nsf/ID/Bayer-to-sell-its-Animal-Health-business-unit-to-Elancofor-76-billion-US-dollars. dead.
  166. Web site: Bayer to Sell Diabetes Unit to KKR Unit for $1.15 Billion. Makiko. Kitamura. 10 June 2015. Bloomberg.
  167. News: Bray. Chad. Bayer to Spin Off Plastics Group to Focus on Health Care. 18 September 2014. The New York Times.
  168. Web site: Gannon. Joyce. Bayer to rename its MaterialScience business Covestro. Pittsburgh Post-Gazette. 1 June 2015.
  169. Web site: Bayer Bilanz, Gewinn und Umsatz Bayer Geschäftsbericht BAY001. wallstreet-online.de. 2018-11-05.
  170. Web site: BAYN.DE Key Statistics BAYER AG NA O.N. Stock – Yahoo Finance. finance.yahoo.com. en-US. 2018-11-05.
  171. News: Bayer to reduce size of management board to five. 2019-09-10. Reuters. 2019-09-23. en.
  172. Web site: Bayer's Integrated Annual Reports . Bayer.
  173. Web site: Bayer Fundamentalanalyse KGV Kennzahlen . 2023-11-28 . boerse.de . de.
  174. Web site: Bayer 04 Leverkusen Fussball GmbH. bayer04.de. 26 January 2017. https://web.archive.org/web/20170126142444/http://www.bayer04.de/b04-deu/de/_site_index.aspx. 26 January 2017. dead.
  175. Web site: Top Employer: Bayer. content.eluta.ca.
  176. http://www.hrc.org/issues/workplace/organization_profile.asp?organization_id=2019&search_id=1&search_type=Quick Workplace | Issues | Human Rights Campaign
  177. Web site: German Index. www.standardethicsindices.eu.
  178. Web site: Awards of Bayer AG . 6 May 2019 . 1 April 2019 . https://web.archive.org/web/20190401024540/https://www.bayer.com/en/awards.aspx . dead .
  179. Web site: The Index.
  180. Web site: Joel . Rosenblatt . Robert . Burnson . Naomi . Kresge . 13 August 2018 . Bayer Takes the Hit After Monsanto Loses Roundup Cancer Trial . Bloomberg . 18 September 2018.
  181. Web site: Jury orders Monsanto to pay $289 million to cancer patient in Roundup lawsuit. USA Today.
  182. News: Burger. Ludwig . Roundup cancer verdict sends Bayer shares sliding . Reuters . 13 August 2018.
  183. News: Bellon . Tina . Bayer's Monsanto asks U.S. court to toss $289 million glyphosate verdict . Reuters . 18 September 2018.
  184. News: Monsanto appeals Roundup cancer verdict . Phys.org . 30 November 2018.
  185. Web site: Roundup maker Monsanto appeals $78.5 million verdict over Bay Area man's cancer . ABC7 San Francisco . 30 November 2018 . 21 November 2018.
  186. News: Egelko . Bob . Award to Vallejo groundskeeper in Monsanto cancer case slashed again – verdict upheld . 3 March 2021 . San Francisco Chronicle . 21 July 2020.
  187. News: Judge cuts $2 billion award for couple with cancer to $86.7 million in Roundup lawsuit. Telford. Taylor. 2019-07-26. The Washington Post. 2019-07-27.
  188. News: Denham . Hannah . Bayer, maker of Roundup weedkiller, agrees to pay $10 billion in cancer settlements . The Washington Post. Nash Holdings . 24 June 2020 . Washington DC.
  189. News: Randazzo . Sara . Bayer Loses Roundup Weedkiller Appeal . The Wall Street Journal. Dow Jones & Company . 20 July 2020 . New York City.
  190. Web site: December 23, 2023 . Bayer wins latest Roundup cancer trial, ending losing streak . Reuters.
  191. Tarazona. Jose V.. Court-Marques. Daniele. Tiramani. Manuela. Reich. Hermine. Pfeil. Rudolf. Istace. Frederique. Crivellente. Federica. 3 April 2017. Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC. Archives of Toxicology. 91. 8. 2723–2743. 10.1007/s00204-017-1962-5. 5515989. 28374158.
  192. Web site: The BfR has finalised its draft report for the re-evaluation of glyphosate – BfR. 2018-08-18.
  193. Book: Encyclopedia of Nanoscience and Society . Guston. David. Ludlow. Karinne. 2010. SAGE Publications, Inc.. 978-1-4129-6987-1. Thousand Oaks, CA. Australian Pesticides and Veterinary Medicines Authority. http://sk.sagepub.com/reference/nanoscience/n22.xml.
  194. Web site: EPA Releases Draft Risk Assessments for Glyphosate. US EPA. OCSPP. 2017-12-18. US EPA. Announcements and Schedules. 2018-08-18.
  195. Web site: 2022-06-18 . Court rejects Trump-era EPA finding that Roundup weed killer is safe . 2023-07-09 . PBS NewsHour . en-us.
  196. News: Thomas . Katie . Bayer and Johnson & Johnson Settle Lawsuits Over Xarelto, a Blood Thinner, for $775 Million . 15 May 2019 . . 25 March 2019.
  197. Web site: Bronstad . Amanda . A Tale of 2 Trials: How These Defense Teams Notched Rare Class Action Verdicts . The Law.com . ALM . 15 May 2019 . New York . 1 March 2019.
  198. Web site: Frankel . Allison . Lessons from a class action trial: Should Bayer's big win embolden defendants? . Reuters. 15 May 2019 . 26 February 2019.
  199. Khoshnood . M. . McHenry . L. . 38140759 . Blood money: Bayer's inventory of HIV-contaminated blood products and third world hemophiliacs. . Accountability in Research . 21 . 6 . 389–400 . California State University . 24785997 . 2014 . 10.1080/08989621.2014.882780 .
  200. Web site: Bayer's Dicamba Hit Tests Patience of Frustrated Investors . Jef . Feeley . Tim . Bross . Tim . Loh . February 14, 2020 . February 17, 2020 . Bloomberg . 2022-02-26.
  201. Web site: Is Fear Driving Sales Of Monsanto's Dicamba-Proof Soybeans?. NPR.
  202. Web site: Monsanto, BASF Will Pay $250 Million in Punitive Damages in First Dicamba Trial. 15 February 2020.
  203. News: Missouri farm awarded $265M in suit against BASF and Bayer . 31 May 2024 . . 15 February 2020.
  204. Web site: Bayer Faces More Monsanto Pain with $265 Million Dicamba Award . 15 February 2020 . 15 February 2020 . https://web.archive.org/web/20200215222031/https://finance.yahoo.com/news/bayer-jury-awards-farmer-15-000039335.html . dead .
  205. News: German firms Bayer and BASF fight $265m US fine over weedkiller. BBC News. 17 February 2020.
  206. Web site: Bayer To Pay More Than $10 Billion To Resolve Cancer Lawsuits Over Weedkiller Roundup. Bill. Chappell. 24 June 2020. NPR.
  207. News: Reeves . J.C. . 15 December 2020 . District Judge orders reduction of punitive damages in dicamba case . 15 December 2020 . Southeast Missourian.
  208. News: Rosenblatt . Joel . Chediak . Mark . 1 December 2020 . Bayer's $650 Million PCB Pollution Settlement Rejected by Judge . 15 December 2020 . Claims Journal.
  209. Stempel, J. (APRIL 04, 2023). "Bayer defeats Merck in lawsuit over talc liabilities" Reuters Healthcare & Pharma. Accessed 4 April 2023.

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