| Conflict: | Battle of Yaunis Khan |
| Partof: | Ottoman–Mamluk War (1516–17) |
| Date: | October 28, 1516 |
| Place: | Khan Yunis |
| Result: | Ottoman victory[1] |
| Combatant1: | Ottoman Empire |
| Combatant2: | Mamluk Sultanate |
| Commander1: | Hadım Sinan Pasha |
| Commander2: | Janbirdi al-Ghazali |
The Battle of Yaunis Khan, also known as the Battle of Khan Yunis (Turkish: Han Yunus Muharebesi), was fought on October 28, 1516 between the Ottoman Empire and the Mamluk Sultanate. The Mamluk cavalry forces led by Janbirdi al-Ghazali attacked the Ottomans that were trying to cross Gaza on their way to Egypt. The Ottomans, led by Grand Vizier Hadım Sinan Pasha, were able to break the Egyptian Mamluk cavalry charge. Al-Ghazali was wounded during the confrontation, and the left-over Mamluk forces and their commander Al-Ghazali retreated to Cairo.[2]