Batanopride Explained

Batanopride (BMY-25,801) is an antiemetic drug of the benzamide class which acts as a selective 5-HT3 receptor antagonist.[1] It was trialled to reduce nausea during cancer chemotherapy, but was never approved for medical use due to dose-limiting side effects including hypotension and long QT syndrome.[2]

Notes and References

  1. Gylys JA, Wright RN, Nicolosi WD, Buyniski JP, Crenshaw RR . BMY-25801, an antiemetic agent free of D2-dopamine receptor antagonist properties . The Journal of Pharmacology and Experimental Therapeutics . 244 . 3 . 830–7 . March 1988 . 2978041 .
  2. Fleming GF, Vokes EE, McEvilly JM, Janisch L, Francher D, Smaldone L . Double-blind, randomized crossover study of metoclopramide and batanopride for prevention of cisplatin-induced emesis . Cancer Chemotherapy and Pharmacology . 1991 . 28 . 3 . 226–7 . 1855280 . 10.1007/bf00685516 . 22520773 .

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