| Ziguinchor Region | |
| Native Name: | |
| Settlement Type: | Region |
| Image Map1: | Map of the departments of the Ziguinchor region of Senegal.png |
| Map Caption1: | Ziguinchor région, divided into 3 départements |
| Coordinates: | 12.7833°N -29°W |
| Subdivision Type: | Country |
| Subdivision Name: | Senegal |
| Parts Type: | Départements |
| P1: | Bignona |
| P2: | Oussouye |
| P3: | Ziguinchor |
| Seat Type: | Capital |
| Seat: | Ziguinchor |
| Unit Pref: | Metric |
| Area Total Km2: | 7352 |
| Population Total: | 612,343 |
| Population As Of: | 2023 census |
| Population Density Km2: | auto |
| Timezone: | GMT |
| Utc Offset: | +0 |
| Blank Name Sec1: | HDI (2021) |
| Blank Info Sec1: | 0.589[1] · 2nd |
Ziguinchor is a region of Senegal (regional capitals have the same name as their respective regions). The region is also referred to historically and popularly as Basse Casamance.
Ziguinchor region is divided into 3 departments: