Basic amino acid antiporter family explained

The Basic Amino Acid Antiporter (ArcD) family (TC# 2.A.118) is a constituent of the IT superfamily.^{[1] [2] [3]} This family consists of proteins from Gram-negative and Gram-positive bacteria (e.g., Streptococcus, Escherichia, Salmonella, Fusobacterium and Borrelia species). The proteins are of about 480 amino acyl residues (aas) in length and have 10-12 putative transmembrane segments (TMSs). Functionally characterized homologues are in the DcuC (TC #2.A.61) and ArsB (TC #2.A.4) families. Some members of the family probably catalyze arginine/ornithine or citrulline/ornithine antiport.^{[4] [5]}

See also

• Ion transporter superfamily
• Amino acid transporters
• DcuC
• ArsB and ArsAB
• Transporter Classification Database

Notes and References

1. Lolkema. Juke S.. Slotboom. Dirk Jan. 2003-04-11. Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis. Journal of Molecular Biology. 327. 5. 901–909. 0022-2836. 12662917. 10.1016/s0022-2836(03)00214-6. 22815736 .
2. Prakash. Shraddha. Cooper. Garret. Singhi. Soumya. Saier. Milton H.. 2003-12-03. The ion transporter superfamily. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618. 1. 79–92. 0006-3002. 14643936. 10.1016/j.bbamem.2003.10.010.
3. Rabus. R.. Jack. D. L.. Kelly. D. J.. Saier. M. H.. 1999-12-01. TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology. 145 (Pt 12). 12. 3431–3445. 10.1099/00221287-145-12-3431. 1350-0872. 10627041. free.
4. Gupta. Radha. Yang. Jun. Dong. Yimin. Swiatlo. Edwin. Zhang. Jing-Ren. Metzger. Dennis W.. Bai. Guangchun. 2013-10-01. Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence. Infection and Immunity. 81. 10. 3903–3911. 10.1128/IAI.00778-13. 1098-5522. 3811789. 23918778.
5. Rimaux. Tom. Rivière. Audrey. Hebert. Elvira María. Mozzi. Fernanda. Weckx. Stefan. De Vuyst. Luc. Leroy. Frédéric. 2013-04-01. A putative transport protein is involved in citrulline excretion and re-uptake during arginine deiminase pathway activity by Lactobacillus sakei. Research in Microbiology. 164. 3. 216–225. 10.1016/j.resmic.2012.11.004. 1769-7123. 23178175. 11336/2348. free.