Basem Al-Shayeb Explained

Basem Al-Shayeb is a founder and former Chief Technology Officer[1] [2] of Amber Bio, a biotechnology startup company in the San Francisco Bay Area which has raised $26 million to develop multi-kilobase RNA editing therapies using CRISPR-Cas.[3] [4] [5] [6]

He received his PhD in Microbial Biology[7] as a National Science Foundation Fellow at the University of California, Berkeley and Innovative Genomics Institute,[8] where he conducted his dissertation work in the lab of the 2020 Nobel Laureate in Chemistry Dr. Jennifer Doudna, and in the Earth and Planetary Science Department advised by Jillian Banfield.[9] According to ORCID records, he is an active peer reviewer for Nature Portfolio research for several journals including Nature, Nature Communications, and Multidisciplinary Journal of Microbial Ecology (ISME).[10]

During his time at UC Berkeley, he led or was co-first author on publications describing the discovery of the largest known bacteriophages in the journal Nature,[11] [12] [13] [14] [15] the smallest CRISPR-Cas genome editing systems in Science and Cell [16] [17] [18] [19] [20] and a new form of extrachromosomal DNA elements, termed "Borgs," found in methane-oxidizing archaea (Methanoperedens spp.) in Nature.[21] [22] [23] [24] [25] Some of the aforementioned CRISPR-Cas enzymes are licensed by Mammoth Biosciences for diagnostic and therapeutic development.[26] He was listed in Forbes 30 Under 30 and Arab America's 30 Under 30 in 2021, [27] [28] and Forbes All-Star Alumni in 2024 for his scientific discoveries and contributions.[29]

Notes and References

  1. Web site: Amber Bio. 2024-05-25. https://web.archive.org/web/20240520185143/https://www.amber.bio/#team. 2024-05-20.
  2. Web site: 2024-02-25 . Amber Bio . 2024-08-17 . web.archive.org.
  3. Web site: Rice . India . This Startup Just Raised $26 Million To Develop Safer Gene Editing Tools . 2024-06-27 . Forbes . en.
  4. Web site: 2023-08-03 . New RNA-Editing Company, Amber Bio, Launches Multi-Kilobase Editing Platform . 2024-06-27 . GEN - Genetic Engineering and Biotechnology News . en-US.
  5. https://www.businesswire.com/news/home/20230803489484/en/Amber-Bio-Raises-26-Million-Seed-Financing-Co-Led-by-Playground-Global-and-Andreessen-Horowitz-to-Advance-New-RNA-Based-Gene-Editing-Platform
  6. Web site: RNA editing start-up Amber Bio launches with $26 million . 2024-06-27 . Chemical & Engineering News . en.
  7. Web site: Basem Al-Shayeb . 2024-08-18 . Plant & Microbial Biology University of California, Berkeley . en.
  8. Web site: Meet an IGI Scientist: Basem Al-Shayeb . 2022-03-13 . Innovative Genomics Institute (IGI) . en-US.
  9. Web site: Basem Al-Shayeb Earth & Planetary Science . 2024-08-18 . eps.berkeley.edu.
  10. Web site: ORCID . 2024-08-17 . orcid.org.
  11. York . Ashley . April 2020 . Too big to be ignored . Nature Reviews Microbiology . en . 18 . 4 . 192–192 . 10.1038/s41579-020-0341-z . 1740-1534.
  12. Web site: Koumoundouros . Tessa . 2020-02-13 . Scientists Discover Giant Viruses With Features Only Seen Before in Living Cells . 2024-08-17 . ScienceAlert . en-US.
  13. Pausch . Patrick . Al-Shayeb . Basem . Bisom-Rapp . Ezra . Tsuchida . Connor A. . Li . Zheng . Cress . Brady F. . Knott . Gavin J. . Jacobsen . Steven E. . Banfield . Jillian F. . Doudna . Jennifer A. . 2020-07-17 . CRISPR-CasΦ from huge phages is a hypercompact genome editor . Science . en . 369 . 6501 . 333–337 . 10.1126/science.abb1400 . 0036-8075 . 8207990 . 32675376.
  14. Web site: 2020-02-13 . Hundreds Of New Viruses With Enormous Genomes Blur The Boundaries Of Life . 2024-08-17 . IFLScience . en.
  15. Web site: Knapp . Alex . 30 Under 30 In Science 2021: Building Better Trees, Supernova Simulations And Holograms . 2024-08-17 . Forbes . en.
  16. Web site: News: Tiny but Mighty: How Researchers Found a New Game-Changing CRISPR Tool . 2024-08-15 . CRISPR Medicine . en.
  17. Web site: Sanders . Robert . 2020-07-16 . Megaphages harbor mini-Cas proteins ideal for gene editing . 2024-08-17 . Berkeley News . en.
  18. Web site: New Compact Genome Editors Found in Viruses . 2024-08-17 . Innovative Genomics Institute (IGI) . en-US.
  19. Web site: The Little Enzyme That Can: Meet the Gene Editor CasX . 2024-08-17 . Innovative Genomics Institute (IGI) . en-US.
  20. Al-Shayeb . Basem . Skopintsev . Petr . Soczek . Katarzyna M. . Stahl . Elizabeth C. . Li . Zheng . Groover . Evan . Smock . Dylan . Eggers . Amy R. . Pausch . Patrick . Cress . Brady F. . Huang . Carolyn J. . Staskawicz . Brian . Savage . David F. . Jacobsen . Steven E. . Banfield . Jillian F. . 2022-11-23 . Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors . Cell . 185 . 24 . 4574–4586.e16 . 10.1016/j.cell.2022.10.020 . 0092-8674.
  21. Web site: Scientists discover Borgs, DNA strands that assimilate genes from their hosts . 2024-08-17 . Chemical & Engineering News . en.
  22. Al-Shayeb . Basem . Schoelmerich . Marie C. . West-Roberts . Jacob . Valentin-Alvarado . Luis E. . Sachdeva . Rohan . Mullen . Susan . Crits-Christoph . Alexander . Wilkins . Michael J. . Williams . Kenneth H. . Doudna . Jennifer A. . Banfield . Jillian F. . October 2022 . Borgs are giant genetic elements with potential to expand metabolic capacity . Nature . en . 610 . 7933 . 731–736 . 10.1038/s41586-022-05256-1 . 1476-4687. 9605863 .
  23. Web site: 2021-08-02 . Resistance is futile, because Star Trek’s Borg are real and can assimilate DNA from microbes . 2024-08-17 . SYFY Official Site . en-US.
  24. Web site: Huang . Lauren . 2021-07-19 . UC Berkeley researchers discover unique DNA sequence with potential to combat climate change . 2024-08-17 . www.dailycal.org . en.
  25. News: 2021-07-30 . Previously undiscovered DNA 'borgs' found on California wetlands . The Independent.
  26. Web site: Etherington . Darrell . 2020-08-12 . Mammoth Biosciences lands exclusive license to new CRISPR proteins that could boost gene editing precision . 2024-08-18 . TechCrunch . en-US.
  27. Web site: Basem Al-Shayeb . 2022-03-13 . Forbes . en.
  28. Web site: 2021-10-06 . Arab America Foundation Announces 30 Under 30 Awardees-Class of 2021 . 2022-10-04 . Arab America . en.
  29. Web site: Forbes 30 Under 30 2024: Science . 2024-08-17 . Forbes . en.

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