Barry Trost Explained

Barry Martin Trost
Birth Place:Philadelphia, Pennsylvania, United States
Field:Organic Chemistry
Work Institution:University of Wisconsin–Madison
Stanford University
Thesis Title:The Structure and Reactivity of Enolate Anions
Thesis Url:https://dspace.mit.edu/handle/1721.1/13430
Thesis Year:1965
Doctoral Advisor:Herbert O. House
Doctoral Students:Brian Coppola
Michael J. Krische
F. Dean Toste
Known For:Tsuji-Trost reaction, Trost ligand, Atom economy
Prizes:ACS Award in Pure Chemistry (1977)
Ernest Guenther Award
William H. Nichols Medal
Arthur C. Cope Award (2004)
The Ryoji Noyori Prize (2013)
Linus Pauling Award (2015)

Barry M. Trost (born June 13, 1941, in Philadelphia) is an American chemist who is the Job and Gertrud Tamaki Professor Emeritus in the School of Humanities and Sciences at Stanford University.[1] The Tsuji-Trost reaction and the Trost ligand are named after him. He is prominent for advancing the concept of atom economy.[2] [3]

Early life and education

Trost was born in Philadelphia, Pennsylvania on June 13, 1941. He studied at the University of Pennsylvania and obtained his B.A. in 1962.[4] He then attended the Massachusetts Institute of Technology for graduate school, where he worked with Herbert O. House on enolate anions, the Mannich reaction, and the Robinson annulation.[5] [6] [7] Trost graduated with his Ph.D. in 1965.

Independent career

Trost moved to the University of Wisconsin–Madison to begin his independent career, and was promoted to professor of chemistry in 1969, and the Vilas Research Professor in 1982. In 1987, he moved to Stanford University as professor of chemistry, and was appointed the Job and Gertrud Tamaki Professor of Humanities and Sciences in 1990. He previously served as chair of the department of chemistry.

, Trost has an h-index of 161 according to Google Scholar and of 140 (1040 documents) according to Scopus.[8]

Research

Trost's research focused on chemical synthesis.[9] In order to build complex target molecules from simple molecules, Trost developed new reactions and reagents, and utilized cascade reactions and tandem reactions. Target molecules have potential applications as novel catalysts, as well as antibiotic and anti-tumor therapeutics.[10]

References

Sources

Notes and References

  1. Web site: Barry Trost Department of Chemistry. May 24, 2021. chemistry.stanford.edu.
  2. Trost. Barry M.. 1991. Atom Economy: A Search for Synthetic Efficiency. Science. 254. 5037. 1471–1477. 1991Sci...254.1471T. 10.1126/science.1962206. 1962206.
  3. Trost. Barry M.. 1995. Atom Economy - A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way. Angewandte Chemie International Edition. 34. 3. 259–281. 10.1002/anie.199502591.
  4. Trost. Barry M.. Toste. F. Dean. Pinkerton. Anthony B.. June 19, 2001. Non-Metathesis Ruthenium-Catalyzed C−C Bond Formation. Chemical Reviews. 101. 7. 2067–2096. 10.1021/cr000666b. 11710241. 0009-2665.
  5. House. Herbert O.. Trost. Barry M.. June 1, 1964. The Mannich Reaction with 2-Methylcyclopentanone and 2-Methylcyclo hexanone1a. The Journal of Organic Chemistry. 29. 6. 1339–1341. 10.1021/jo01029a016. 0022-3263.
  6. House. Herbert O.. Trost. Barry M.. May 1, 1965. The Chemistry of Carbanions. IX. The Potassium and Lithium Enolates Derived from Cyclic Ketones1. The Journal of Organic Chemistry. 30. 5. 1341–1348. 10.1021/jo01016a001. 0022-3263.
  7. House. Herbert O.. Trost. Barry M.. Magin. Ralph W.. Carlson. Robert G.. Franck. Richard W.. Rasmusson. Gary H.. August 1, 1965. By-products of the Robinson Annelation Reaction with Cyclohexanone, Cyclopentanone, and Cyclopentane-1,2-dione1. The Journal of Organic Chemistry. 30. 8. 2513–2519. 10.1021/jo01019a004. 0022-3263.
  8. Web site: Scopus preview – Trost, Barry M. – Author details – Scopus. www.scopus.com. October 17, 2021.
  9. Web site: Trost Group Home . Stanford University . 30 March 2017 . 17 October 2021.
  10. Web site: Barry Trost. 17 October 2021. Department of Chemistry.