Barrierpepsin Explained

Barrierpepsin
Ec Number:3.4.23.35
Cas Number:152060-38-3

Barrierpepsin (barrier proteinase, Bar proteinase) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction

Selective cleavage of -Leu6-Lys- bond in the pheromone alpha-mating factor

This endopeptidase is present in baker's yeast (Saccharomyces cerevisiae).

Notes and References

  1. MacKay VL, Welch SK, Insley MY, Manney TR, Holly J, Saari GC, Parker ML . The Saccharomyces cerevisiae BAR1 gene encodes an exported protein with homology to pepsin . Proceedings of the National Academy of Sciences of the United States of America . 85 . 1 . 55–9 . January 1988 . 3124102 . 279480 . 10.1073/pnas.85.1.55 . 1988PNAS...85...55M . free .
  2. Book: MacKay VL, Armstrong J, Yip C, Welch S, Walker K, Osborn S, Sheppard P, Forstrom J . Structure and Function of the Aspartic Proteinases . Characterization of the Bar Proteinase, an Extracellular Enzyme from the Yeast Saccharomyces Cerevisiae . Advances in Experimental Medicine and Biology . 306 . 161–72 . 1991 . 1812704 . 10.1007/978-1-4684-6012-4_21 . 978-1-4684-6014-8 .