Baljet reaction explained

The Baljet reaction is a qualitative and quantitative method of analysis published by Henri Baljet in 1918. This chemical reaction is used for the detection and colorimetric[1] determination of cardenolides. To the sample, an aqueous hydroxide solution and an ethanolic picric acid solution is combined and added, with a positive test turning orange or red.[2] [3] The mechanism involves cardenolides 1 reacting in alkaline solution with picric acid 2 to form stabilized Meisenheimer complexes, as shown with the resonance form 3a to 3c:

See also

Notes and References

  1. Bell . Frederick K. . Krantz . John C. . 1949-02-01 . Digitalis. VIII. The Baljet Reaction, Digitoxm and Digitoxigenin . Journal of the American Pharmaceutical Association (Scientific Ed.) . 38 . 2 . 107–109 . 10.1002/jps.3030380214 . 18111465 . 0095-9553.
  2. Siegfried Ebel, Hermann J. Roth: Lexikon der Pharmazie 1987, Georg Thieme Verlag Stuttgart, New York, ISBN 3-13-672201-9, S. 80.
  3. Web site: GYLCOSIDES Presented by BAHADUR SINGH HOD - ppt download . 2024-11-18 . slideplayer.com.

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