Bacoside A Explained

Bacoside A is a mixture of chemical compounds, known as bacosides, isolated from Bacopa monnieri.[1] Its major constituents include the saponins bacoside A3, bacopaside II, bacopasaponin C, and jujubogenin isomer of bacopasaponin C.[2] [3] The mixture has been studied in in vitro experiments and animal models for its potential neuroprotectivity.[4] [5] [6] [7] [8] [9] [10] [11]

Notes and References

  1. Majumdar . etal . 2013 . Bacosides and Neuroprotection . Natural Products . 3639–3660. 10.1007/978-3-642-22144-6_157 . 978-3-642-22143-9 .
  2. Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC . M. Deepak . G. K. Sangli . P. C. Arun . A. Amit . 10.1002/pca.805 . 15688952 . Phytochemical Analysis . 16 . 1 . 24–29 . January–February 2005.
  3. Web site: Bacoside A, mixture of Bacoside A3, Bacopaside II, Bacopaside X and Bacopasaponin C. .
  4. 23975094. 2013. Thomas. RB. Joy. S. Ajayan. MS. Paulose. CS. Neuroprotective Potential of Bacopa monnieri and Bacoside a Against Dopamine Receptor Dysfunction in the Cerebral Cortex of Neonatal Hypoglycaemic Rats. 33. 8. 1065–74. 10.1007/s10571-013-9973-0. Cellular and Molecular Neurobiology. 9733669.
  5. Russo . Borrelli . 2005 . Bacopa monniera, a reputed nootropic plant: an overview . Phytomedicine . 12. 4. 305–317. 10.1016/j.phymed.2003.12.008 . 15898709.
  6. Aguiar and Borowski, 2013. Neuropharmacological Review of the Nootropic Herb Bacopa monnieri. Rejuvenation Research. http://online.liebertpub.com/doi/abs/10.1089/rej.2013.1431
  7. Bhattacharya . SK . Bhattacharya . A . Kumar . A . Ghosal . S . 2000 . Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus . Phytother Res . 14 . 3. 174–179 . 10.1002/(sici)1099-1573(200005)14:3<174::aid-ptr624>3.0.co;2-o. 10815010 .
  8. Anbarasi . K . Vani . G . Balakrishna . K . Devi . CS . 2006 . Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats . Life Sci . 78 . 12. 1378–1384 . 10.1016/j.lfs.2005.07.030 . 16226278.
  9. Anbarasi . K . Sabitha . KE . Devi . CS . 2005 . Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of bacoside A. . Environ Toxicol Pharmacol . 20 . 2. 345–350 . 10.1016/j.etap.2005.03.006. 21783610 .
  10. Vohora . D . Pal . SN . Pillai . KK . 2000 . Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant . J Ethnopharmacol . 71 . 3. 383–390 . 10.1016/s0378-8741(99)00213-5. 10940574 .
  11. Hota . SK . Barhwal . K . Baitharu . I . Prasad . D . Singh . SB . Ilavazhagan . G . 2009 . Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment . Neurobiol Dis . 34 . 1. 23–39 . 10.1016/j.nbd.2008.12.006. 19154788 . 207064319 .

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