BU-48 explained

BU-48 is a drug that is used in scientific research. It is from the oripavine family, related to better-known drugs such as etorphine and buprenorphine.

The parent compound from which BU-48 was derived (with N-methyl rather than methylcyclopropyl on the nitrogen and lacking the aliphatic hydroxyl group) is a powerful μ-opioid agonist 1000 times more potent than morphine,[1] but in contrast BU-48 has only weak analgesic effects and instead acts primarily as a δ-opioid agonist. Its main effects are to produce convulsions,[2] but it may also have antidepressant effects.[3]

See also

Notes and References

  1. Lewis JW, Bentley KW, Cowan A . Narcotic analgesics and antagonists . Annual Review of Pharmacology . 11 . 241–70 . 1971 . 4948499 . 10.1146/annurev.pa.11.040171.001325 .
  2. Broom DC, Guo L, Coop A, Husbands SM, Lewis JW, Woods JH, Traynor JR . BU48: a novel buprenorphine analog that exhibits delta-opioid-mediated convulsions but not delta-opioid-mediated antinociception in mice . The Journal of Pharmacology and Experimental Therapeutics . 294 . 3 . 1195–200 . September 2000 . 10945877 .
  3. Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH . Behavioral effects of delta-opioid receptor agonists: potential antidepressants? . Japanese Journal of Pharmacology . 90 . 1 . 1–6 . September 2002 . 12396021 . 10.1254/jjp.90.1 . free .

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