Protein BTG3 explained

Protein BTG3 is a protein that in humans is encoded by the BTG3 gene.^{[1] [2]}

The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system.

Further reading

• Matsuda S, Rouault J, Magaud J, Berthet C . In search of a function for the TIS21/PC3/BTG1/TOB family . FEBS Lett. . 497 . 2–3 . 67–72 . 2001 . 11377414 . 10.1016/S0014-5793(01)02436-X . 43120613 .
• Guéhenneux F . Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle . Leukemia . 11 . 3 . 370–5 . 1997 . 9067576 . 10.1038/sj.leu.2400599 . Duret L . Callanan MB . Bouhas . R . Hayette . S . Berthet . C . Samarut . C . Rimokh . R . Birot . A M . 12912055 .
• Hattori M . The DNA sequence of human chromosome 21 . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . Fujiyama A . Taylor TD . Taylor . T. D. . Watanabe . H. . Yada . T. . Park . H.-S. . Toyoda . A. . Ishii . K. . 2000Natur.405..311H . free .
• Birot A . Identification and molecular analysis of BANP . Gene . 253 . 2 . 189–96 . 2000 . 10940556 . 10.1016/S0378-1119(00)00244-4 . Duret L . Bartholin L . Santalucia . Bénédicte . Tigaud . Isabelle . Magaud . Jean-Pierre . Rouault . Jean-Pierre .
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T . Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex . Jpn. J. Cancer Res. . 92 . 6 . 592–6 . 2001 . 11429045 . 10.1111/j.1349-7006.2001.tb01135.x. 5926753 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . Hao T . Shaw C . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . 13709685 . free .
• Ou YH . The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1 . EMBO J. . 26 . 17 . 3968–80 . 2007 . 17690688 . 10.1038/sj.emboj.7601825 . 1994125 . Chung PH . Hsu FF . Sun . Te-Ping . Chang . Wen-Ying . Shieh . Sheau-Yann .

Notes and References

1. Yoshida Y, Matsuda S, Ikematsu N, Kawamura-Tsuzuku J, Inazawa J, Umemori H, Yamamoto T . ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system . Oncogene . 16 . 20 . 2687–93 . Jun 1998 . 9632145 . 10.1038/sj.onc.1201805 . 10053424 . free .
2. Web site: Entrez Gene: BTG3 BTG family, member 3.