BTF3 explained
Transcription factor BTF3 is a protein that in humans is encoded by the BTF3 gene.[1] [2] [3] [4]
Function
This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.
Interactions
BTF3 has been shown to interact with CSNK2B.[5]
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Transcription factor BTF3
Further reading
- Wiedmann B, Sakai H, Davis TA, Wiedmann M . A protein complex required for signal-sequence-specific sorting and translocation . Nature . 370 . 6489 . 434–40 . 1994 . 8047162 . 10.1038/370434a0 . 1994Natur.370..434W . 4353902 .
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Grein S, Pyerin W . BTF3 is a potential new substrate of protein kinase CK2 . Mol. Cell. Biochem. . 191 . 1–2 . 121–8 . 1999 . 10094400 . 10.1023/A:1006806226764 . 1057554 .
- Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M . Creation of genome-wide protein expression libraries using random activation of gene expression . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . 25064683 .
- Kusumawidjaja G, Kayed H, Giese N, Bauer A, Erkan M, Giese T, Hoheise JD, Friess H, Kleeff J . Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells . Cancer Biol. Ther. . 6 . 3 . 367–76 . 2007 . 17312387 . 10.4161/cbt.6.3.3704 . 10.1.1.410.5257 . 9044882 .
- Symes AJ, Eilertsen M, Millar M, Nariculam J, Freeman A, Notara M, Feneley MR, Patel HR, Patel HR, Masters JR, Ahmed A . Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue . PLOS ONE . 8 . 12 . e84295 . 2013 . 24386364 . 3874000 . 10.1371/journal.pone.0084295 . 2013PLoSO...884295S . free .
Notes and References
- Zheng XM, Black D, Chambon P, Egly JM . Sequencing and expression of complementary DNA for the general transcription factor BTF3 . Nature . 344 . 6266 . 556–9 . May 1990 . 2320128 . 10.1038/344556a0 . 1990Natur.344..556Z . 4227320 .
- Kanno M, Chalut C, Egly JM . Genomic structure of the putative BTF3 transcription factor . Gene . 117 . 2 . 219–28 . Sep 1992 . 1386332 . 10.1016/0378-1119(92)90732-5 .
- Freire MA . Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex . Gene . 345 . 2 . 271–7 . Apr 2005 . 15716105 . 10.1016/j.gene.2004.11.030 .
- Web site: Entrez Gene: BTF3 basic transcription factor 3.
- Grein S, Pyerin W . BTF3 is a potential new substrate of protein kinase CK2 . Mol. Cell. Biochem. . 191 . 1–2 . 121–8 . Jan 1999 . 10094400 . 10.1023/A:1006806226764 . 1057554 .
