Bromodomain and WD repeat-containing protein 1 explained

Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1 gene.^[1]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and 8 WD repeats, and the function of this protein is not known. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends.

See also

• BRWD3
• WDR11, also known as BRWD2

Further reading

• Hu YH . Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins . BMC Genomics . 7. 155 . 2006 . 16780588 . 10.1186/1471-2164-7-155 . 1526728 . vanc. Warnatz HJ . Vanhecke D . 3 . Wagner . Florian . Fiebitz . Andrea . Thamm . Sabine . Kahlem . Pascal . Lehrach . Hans . Yaspo . Marie-Laure . free .
• Huang H, Rambaldi I, Daniels E, Featherstone M . Expression of the Wdr9 gene and protein products during mouse development . Dev. Dyn. . 227 . 4 . 608–14 . 2004 . 12889071 . 10.1002/dvdy.10344 . 2056808 . free .
• Ramos VC . Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21 . Biochim. Biophys. Acta . 1577 . 3 . 377–83 . 2002 . 12359327 . 10.1016/s0167-4781(02)00421-9. vanc. Vidal-Taboada J . Bergoñon S . 3 . Egeo . A . Fisher . EM . Scartezzini . P . Oliva . R .
• Vidal-Taboada JM . High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2 . Biochem. Biophys. Res. Commun. . 243 . 2 . 572–8 . 1998 . 9480850 . 10.1006/bbrc.1998.8141 . vanc. Bergoñón S . Sánchez M . 3 . López-Acedo . Cristina . Groet . Jurgen . Nizetic . Dean . Egeo . Aliana . Scartezzini . Paolo . Katsanis . Nicolas .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Web site: Entrez Gene: BRWD1 bromodomain and WD repeat domain containing 1.