BRSK1 explained

BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene.^[1]

Further reading

• Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR . LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 . The EMBO Journal . 23 . 4 . 833–43 . Feb 2004 . 14976552 . 381014 . 10.1038/sj.emboj.7600110 .
• Lu R, Niida H, Nakanishi M . Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function . The Journal of Biological Chemistry . 279 . 30 . 31164–70 . Jul 2004 . 15150265 . 10.1074/jbc.M404728200 . free .
• Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR . 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK . Journal of Cell Science . 118 . Pt 23 . 5661–73 . Dec 2005 . 16306228 . 10.1242/jcs.02670 . free .
• Inoue E, Mochida S, Takagi H, Higa S, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Yao I, Takeuchi K, Kitajima I, Setou M, Ohtsuka T, Takai Y . SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release . Neuron . 50 . 2 . 261–75 . Apr 2006 . 16630837 . 10.1016/j.neuron.2006.03.018 . 15232412 . free .
• Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR . Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains . The Biochemical Journal . 411 . 2 . 249–60 . Apr 2008 . 18254724 . 10.1042/BJ20080067 . 13038944 .
• Bright NJ, Carling D, Thornton C . Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation . The Journal of Biological Chemistry . 283 . 22 . 14946–54 . May 2008 . 18339622 . 3258900 . 10.1074/jbc.M710381200 . free .
• Fogarty S, Hardie DG . C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest . The Journal of Biological Chemistry . 284 . 1 . 77–84 . Jan 2009 . 18854318 . 2610510 . 10.1074/jbc.M806152200 . free .
• Stolk L, Zhai G, van Meurs JB, Verbiest MM, Visser JA, Estrada K, Rivadeneira F, Williams FM, Cherkas L, Deloukas P, Soranzo N, de Keyzer JJ, Pop VJ, Lips P, Lebrun CE, van der Schouw YT, Grobbee DE, Witteman J, Hofman A, Pols HA, Laven JS, Spector TD, Uitterlinden AG . Loci at chromosomes 13, 19 and 20 influence age at natural menopause . Nature Genetics . 41 . 6 . 645–7 . Jun 2009 . 19448619 . 3000545 . 10.1038/ng.387 .
• He C, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI . Genome-wide association studies identify loci associated with age at menarche and age at natural menopause . Nature Genetics . 41 . 6 . 724–8 . Jun 2009 . 19448621 . 2888798 . 10.1038/ng.385 .
• Alvarado-Kristensson M, Rodríguez MJ, Silió V, Valpuesta JM, Carrera AC . SADB phosphorylation of gamma-tubulin regulates centrosome duplication . Nature Cell Biology . 11 . 9 . 1081–92 . Sep 2009 . 19648910 . 10.1038/ncb1921 . 41209616 .

Notes and References

1. Web site: Entrez Gene: BR serine/threonine kinase 1. 2011-10-18 .