BRMS1 explained

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.^[1]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.^[2] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.^[3]

Further reading

• Meehan WJ, Welch DR . Breast cancer metastasis suppressor 1: update. . Clin. Exp. Metastasis . 20 . 1 . 45–50 . 2003 . 12650606 . 10.1023/A:1022542519586 . 26142383 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Samant RS, Debies MT, Shevde LA . Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). . . 97 . 1 . 15–20 . 2002 . 11774238 . 10.1002/ijc.1569 . 19747938 . etal. free .
• Shevde LA, Samant RS, Goldberg SF . Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. . . 273 . 2 . 229–39 . 2002 . 11822878 . 10.1006/excr.2001.5452 . etal.
• Janneau JL, Maldonado-Estrada J, Tachdjian G . Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. . . 87 . 11 . 5336–9 . 2002 . 12414911 . 10.1210/jc.2002-021093 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Meehan WJ, Samant RS, Hopper JE . Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription . . 279 . 2 . 1562–9 . 2004 . 14581478 . 10.1074/jbc.M307969200 . etal. free .
• Cicek M, Samant RS, Kinter M . Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells . Clin. Exp. Metastasis . 21 . 2 . 149–57 . 2004 . 15168732 . 10.1023/B:CLIN.0000024729.19084.f0 . 19383717 . etal.
• Nikolaev AY, Papanikolaou NA, Li M . Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex . . 323 . 4 . 1216–22 . 2004 . 15451426 . 10.1016/j.bbrc.2004.08.227 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Stark AM, Tongers K, Maass N . Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases . . 131 . 3 . 191–8 . 2005 . 15592684 . 10.1007/s00432-004-0629-9 . 12411341 . etal.
• DeWald DB, Torabinejad J, Samant RS . Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells . Cancer Res. . 65 . 3 . 713–7 . 2005 . 10.1158/0008-5472.713.65.3 . 15705865 . 24886361 . etal. free .
• Cicek M, Fukuyama R, Welch DR . Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity . Cancer Res. . 65 . 9 . 3586–95 . 2005 . 15867352 . 10.1158/0008-5472.CAN-04-3139 . etal. free .
• Hurst DR, Mehta A, Moore BP . Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone . Biochem. Biophys. Res. Commun. . 348 . 4 . 1429–35 . 2006 . 16919237 . 10.1016/j.bbrc.2006.08.005 . 1557677 . etal.
• Samant RS, Clark DW, Fillmore RA . Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation . Mol. Cancer . 6 . 6 . 2007 . 17227585 . 10.1186/1476-4598-6-6 . 1796551 . etal . free .
• Rivera J, Megias D, Bravo J . Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1 . . 6 . 10 . 4006–18 . 2007 . 17854218 . 10.1021/pr0703167 .

Notes and References

1. Seraj MJ, Samant RS, Verderame MF, Welch DR . Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13 . . 60 . 11 . 2764–9 . Jun 2000 . 10850410 .
2. https://www.sciencedaily.com/releases/2000/06/000612084928.htm Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene
3. Web site: Entrez Gene: BRMS1 breast cancer metastasis suppressor 1.