BRL-52537 explained

BRL-52537 is a drug which acts as a potent and highly selective κ-opioid agonist.^[1] It has neuroprotective effects in animal studies,^{[2] [3]} and is used for research into potential treatments for stroke and heart attack as well as more general brain research.^{[4] [5] [6]}

Notes and References

1. Vecchietti V, Giordani A, Giardina G, Colle R, Clarke GD . (2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics . Journal of Medicinal Chemistry . 34 . 1 . 397–403 . January 1991 . 1846921 . 10.1021/jm00105a061.
2. Goyagi T, Toung TJ, Kirsch JR, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A . Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats . Stroke: A Journal of Cerebral Circulation . 34 . 6 . 1533–8 . June 2003 . 12738895 . 10.1161/01.STR.0000072512.30658.E7 . free .
3. Zhang Z, Chen TY, Kirsch JR, Toung TJ, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A . Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats . Anesthesia and Analgesia . 97 . 6 . 1776–83 . December 2003 . 14633559 . 10.1213/01.ane.0000087800.56290.2e. free .
4. Chen TY, Goyagi T, Toung TJ, Kirsch JR, Hurn PD, Koehler RC, Bhardwaj A . Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats . Stroke: A Journal of Cerebral Circulation . 35 . 5 . 1180–5 . May 2004 . 15031456 . 10.1161/01.STR.0000125011.93188.c6 . free .
5. Peart JN, Gross ER, Gross GJ . Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction . Journal of Cardiovascular Pharmacology . 43 . 3 . 410–5 . March 2004 . 15076225 . 10.1097/00005344-200403000-00012. free .
6. Britt JP, McGehee DS . Presynaptic opioid and nicotinic receptor modulation of dopamine overflow in the nucleus accumbens . Journal of Neuroscience . 28 . 7 . 1672–81 . February 2008 . 18272687 . 6671549. 10.1523/JNEUROSCI.4275-07.2008 . free .