BRD7 explained

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.^{[1] [2] [3]}

Interactions

BRD7 has been shown to interact with IRF2^[4] and HNRPUL1.^[5]

Azoospermia

BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced.^[6] Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.

Further reading

• Staal A . Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2 . J. Cell. Physiol. . 185 . 2 . 269–279 . 2000 . 11025449 . 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L . vanc. Enserink JM . Stein JL . 3 . Stein . Gary S. . Van Wijnen . Andre J. . 22932901 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Kzhyshkowska J, Rusch A, Wolf H, Dobner T . Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7 . Biochem. J. . 371 . Pt 2 . 385–93 . 2003 . 12489984 . 10.1042/BJ20021281 . 1223277 .
• Zhou M . [Expression of BRD7-interacting proteins, BRD2 and BRD3, in nasopharyngeal carcinoma tissues] . AI Zheng . 22 . 2 . 123–7 . 2003 . 12600283 . vanc. Peng C . Nie XM . 3 . Zhang . BC . Zhu . SG . Yu . Y . Li . XL . Li . GY .
• Tomarev SI . Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis . Invest. Ophthalmol. Vis. Sci. . 44 . 6 . 2588–2596 . 2003 . 12766061 . 10.1167/iovs.02-1099 . vanc. Wistow G . Raymond V . 3 . Dubois . S . Malyukova . I . free.
• Zhang XM . Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer . World J. Gastroenterol. . 9 . 8 . 1729–33 . 2003 . 12918109 . 10.3748/wjg.v9.i8.1729. vanc. Wang XY . Sheng SR . 3 . Wang . JR . Li . J . 4611532 . free .
• Kim S, Lee J, Park J, Chung J . BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta . Cancer Res. . 63 . 16 . 4792–5 . 2003 . 12941796 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Zhou J . BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways . J. Cell. Physiol. . 200 . 1 . 89–98 . 2004 . 15137061 . 10.1002/jcp.20013 . vanc. Ma J . Zhang BC . 3 . Li . Xiao-Ling . Shen . Shou-Rong . Zhu . Shi-Guo . Xiong . Wei . Liu . Hua-Ying . Huang . He . 10383569 .
• Goehler H . A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease . Mol. Cell . 15 . 6 . 853–865 . 2004 . 15383276 . 10.1016/j.molcel.2004.09.016 . vanc. Lalowski M . Stelzl U . 3 . Waelter . Stephanie . Stroedicke . Martin . Worm . Uwe . Droege . Anja . Lindenberg . Katrin S. . Knoblich . Maria . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Peng C . The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain . J. Cell. Biochem. . 97 . 4 . 882–892 . 2006 . 16265664 . 10.1002/jcb.20645 . vanc. Zhou J . Liu HY . 3 . Ming . Zhou . Li . Wang Li . Hong . Zhang Qiu . Xin . Yang Yi . Wei . Xiong . Rong . Shen Shou . 25852399 .
• Zhou M . Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression . J. Cell. Biochem. . 98 . 4 . 920–930 . 2006 . 16475162 . 10.1002/jcb.20788 . vanc. Liu H . Xu X . 3 . Zhou . Houde . Li . Xiaoling . Peng . Cong . Shen . Shourong . Xiong . Wei . Ma . Jian . 23757847 .
• Zhou M . BRD2 is one of BRD7-interacting proteins and its over-expression could initiate apoptosis . Mol. Cell. Biochem. . 292 . 1–2 . 205–212 . 2007 . 16786191 . 10.1007/s11010-006-9233-4 . vanc. Xu XJ . Zhou HD . 3 . Liu . Hua-Ying . He . Jia-Jin . Li . Xiao-Ling . Peng . Cong . Xiong . Wei . Fan . Song-Qing . 5979230 .
• Liu H . Cloning and characterization of the BRD7 gene promoter . DNA Cell Biol. . 25 . 6 . 346–358 . 2006 . 16792505 . 10.1089/dna.2006.25.346 . vanc. Peng C . Zhou M . 3 . Zhou . Jie . Shen . Shourong . Zhou . Houde . Xiong . Wei . Luo . Xiaomin . Peng . Shuping .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.

Notes and References

1. Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W . Identification and molecular characterization of BP75, a novel bromodomain-containing protein . FEBS Lett . 459 . 3 . 291–298 . November 1999 . 10526152 . 10.1016/S0014-5793(99)01191-6 . 41216030 . free .
2. Kaeser MD, Aslanian A, Dong MQ, ((Yates JR III)), Emerson BM . BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells . J Biol Chem . 283 . 47 . 32254–32263 . November 2008 . 18809673 . 2583284 . 10.1074/jbc.M806061200 . free .
3. Web site: Entrez Gene: BRD7 bromodomain containing 7.
4. Staal . A . Enserink J M . Stein J L . Stein G S . van Wijnen A J . November 2000 . Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2 . J. Cell. Physiol. . 185 . 2 . 269–279 . UNITED STATES. 0021-9541. 11025449 . 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L . 22932901 .
5. Kzhyshkowska . Julia . Rusch Andre . Wolf Hans . Dobner Thomas . April 2003 . Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7 . Biochem. J. . 371 . Pt 2 . 385–93 . England. 0264-6021. 12489984 . 10.1042/BJ20021281 . 1223277 .
6. Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, Liu Y, Fan L, Xiong W, Ma J, Peng S, Zeng Z, Zhou Y, Li X, Li Z, Li X, Schmitt DC, Tan M, Li G, Zhou M . Knockout of BRD7 results in impaired spermatogenesis and male infertility . Sci Rep . 6 . 21776 . 2016 . 26878912 . 4754950 . 10.1038/srep21776 . 2016NatSR...621776W .