BRCT domain explained

Symbol:	BRCT
BRCA1 C Terminus (BRCT) domain
Pfam:	PF00533
Interpro:	IPR001357
Scop:	1cdz
Cdd:	cd00027
Pdb:	B:1906-1957 B:1906-1957 A:1906-1957 C:1795-1835 A:1589-1669 C:1646-1723 X:1646-1723 A:1646-1723 X:1646-1723 A:1646-1723 A:1646-1723 A:1646-1723 A:91-166 A:589-664 A:385-463 A:354-431 C:681-717 A:538-616 A:1756-1842 A:27-111

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.

The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage,^[1] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.^[2]

Examples

Human proteins containing this domain include:

• BARD1; BRCA1
• CTDP1; TDT or DNTT
• ECT2
• LIG4
• MCPH1; MDC1
• NBN
• PARP1; PARP4; PAXIP1; PES1
• REV1; RFC1; TOPBP1; TP53BP1; XRCC1

Notes and References

1. Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF . A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins . FASEB J. . 11 . 1 . 68–76 . 1997 . 10.1096/fasebj.11.1.9034168 . free . 9034168. 16457619 .
2. 10.1126/science.1088753 . Yu X, Chini CC, He M, Mer G, Chen J . The BRCT domain is a phospho-protein binding domain . Science . 302 . 5645 . 639–642 . 2003 . 14576433. 2003Sci...302..639Y . 29407635 .