BRAP explained

BRCA1 associated protein is a protein that in braphogs is encoded by the BRAP gene.^[1]

Function

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008].

Further reading

• Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA . Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP . Nature . 427 . 6971 . 256–60 . January 2004 . 14724641 . 10.1038/nature02237 . 2004Natur.427..256M . 4416552 .
• Asada M, Ohmi K, Delia D, Enosawa S, Suzuki S, Yuo A, Suzuki H, Mizutani S . Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation . Mol. Cell. Biol. . 24 . 18 . 8236–43 . September 2004 . 15340083 . 515069 . 10.1128/MCB.24.18.8236-8243.2004 .
• Chen C, Lewis RE, White MA . IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds . J. Biol. Chem. . 283 . 19 . 12789–96 . May 2008 . 18332145 . 2442335 . 10.1074/jbc.M709305200 . free .
• Mallin EA, Pavlicek W . 55-year-old woman with menopausal symptoms and a family history of breast cancer . Mayo Clin. Proc. . 83 . 4 . 485–8 . April 2008 . 18380995 . 10.4065/83.4.485 .
• Czyzyk J, Chen HC, Bottomly K, Flavell RA . p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells . J. Biol. Chem. . 283 . 34 . 23004–15 . August 2008 . 18577512 . 2516986 . 10.1074/jbc.M804084200 . free .
• Keinan-Boker L, Lerner-Geva L, Kaufman B, Meirow D . Pregnancy-associated breast cancer . Isr. Med. Assoc. J. . 10 . 10 . 722–7 . October 2008 . 19009954 .
• Chen JS, Hu HY, Zhang S, He M, Hu RM . Brap2 facilitates HsCdc14A Lys-63 linked ubiquitin modification . Biotechnol. Lett. . 31 . 5 . 615–21 . May 2009 . 19152073 . 10.1007/s10529-009-9914-7 . 22550914 .
• Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T . SNPs in BRAP associated with risk of myocardial infarction in Asian populations . Nat. Genet. . 41 . 3 . 329–33 . March 2009 . 19198608 . 10.1038/ng.326 . 27136281 .
• Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T . SNPs in BRAP associated with risk of myocardial infarction in Asian populations . Nat. Genet. . 41 . 3 . 329–33 . March 2009 . 19198608 . 10.1038/ng.326 . 27136281 .

Notes and References

1. Web site: Entrez Gene: BRCA1 associated protein. 2018-03-23.