BPY2 explained

Testis-specific basic protein Y 2 also known as basic charge, Y-linked 2 is a protein that in humans is encoded by the BPY2 gene which resides on the Y chromosome.^[1]

Function

This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palindromic region.^[2]

Further reading

• Repping S, van Daalen SK, Korver CM . A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region . Genomics . 83 . 6 . 1046–52 . 2004 . 15177557 . 10.1016/j.ygeno.2003.12.018 . etal.
• Tse JY, Wong EY, Cheung AN . Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility . Biol. Reprod. . 69 . 3 . 746–51 . 2003 . 12724276 . 10.1095/biolreprod.103.015792 . etal. free .
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ . The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes . Nature . 423 . 6942 . 825–37 . 2003 . 12815422 . 10.1038/nature01722 . 2003Natur.423..825S . etal. free .
• Choi J, Koh E, Suzuki H . Alu sequence variants of the BPY2 gene in proven fertile and infertile men with Sertoli cell-only phenotype . Int. J. Urol. . 14 . 5 . 431–5 . 2007 . 17511727 . 10.1111/j.1442-2042.2007.01741.x . 12258681 . etal.
• Yang Y, Ma M, Li L . Differential effect of specific gr/gr deletion subtypes on spermatogenesis in the Chinese Han population . International Journal of Andrology . 33. 5. 745–54 . 2009 . 20039973 . 10.1111/j.1365-2605.2009.01015.x . etal. free .
• Wong EY, Tse JY, Yao KM . Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein . Biol. Reprod. . 70 . 3 . 775–84 . 2004 . 14627543 . 10.1095/biolreprod.103.018531 . etal. free .
• Wong EY, Tse JY, Yao KM . VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A . Biochem. Biophys. Res. Commun. . 296 . 5 . 1104–11 . 2002 . 12207887 . 10.1016/S0006-291X(02)02040-5 . etal.

Notes and References

1. Lahn BT, Page DC . Functional coherence of the human Y chromosome . Science . 278 . 5338 . 675–80 . October 1997 . 9381176 . 10.1126/science.278.5338.675 . 1997Sci...278..675L .
2. Web site: Entrez Gene: RPS4Y1 ribosomal protein S4, Y-linked 1.